HitPredict

Interactor 1: ERC2 (O15083)
ERC protein 2
Gene: ERC2

Interactor 2: RIMS1 (Q86UR5)
Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2)
Gene: RIMS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

Property	Details
Experiments	14734538, 12163476, 37207277
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0042734 - presynaptic membrane GO:0048167 - regulation of synaptic plasticity GO:0048786 - presynaptic active zone GO:0048788 - cytoskeleton of presynaptic active zone
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 957 Hs			1 1692
+	Hs
		725194 MYH10_HUMAN (322-957): 9.67e-32: 136: 12.15		RIMS1_HUMAN (1-1692): 0: 972: 100.00
+	Hs
		1199973 RB6I2_HUMAN (32-652): 2.31e-20: 99.4: 10.39		RIMS1_HUMAN (1-1692): 0: 972: 100.00
+	Hs
		724903 MYH9_HUMAN (21-480): 5.51e-17: 88.6: 10.13		RIMS1_HUMAN (1-1692): 0: 972: 100.00
+	Rn
		1195024 RB6I2_RAT (1-957): 1.26e-66: 243: 72.08		RIMS1_RAT (1-1692): 0: 816: 80.71
+	Hs
		166846 ERC2_HUMAN (1-957): 8.46e-83: 289: 100.00		UN13A_HUMAN (756-1691): 6.08e-62: 236: 11.30
+	Rn
		1195025 RB6I2_RAT (1-957): 1.26e-66: 243: 72.08		RIMS2_RAT (303-1692): 9.75e-68: 255: 29.38
+	Hs
		166848 ERC2_HUMAN (1-957): 8.46e-83: 289: 100.00		PCLO_HUMAN (1446-1666): 1.18e-29: 131: 21.37
+	Hs
		148967 CTRO_HUMAN (357-916): 6.23e-14: 78.6: 15.69		SYT10_HUMAN (421-896): 6.81e-48: 182: 17.22
+	Hs
		128891 MY18A_HUMAN (219-918): 7.67e-28: 124: 15.23		P3C2A_HUMAN (1538-1664): 1.27e-23: 111: 27.48
+	Ce
		218525 O44490_CAEEL (157-779): 3.4e-16: 85.5: 15.88		UNC13_CAEEL (879-1662): 3.45e-34: 146: 11.08
+	Hs
		277815 MYH3_HUMAN (18-693): 1.02e-29: 130: 10.44		DYSF_HUMAN (1553-1686): 1.03e-14: 82.3: 20.00
+	Hs
		149481 CTRO_HUMAN (357-916): 6.23e-14: 78.6: 15.69		PCLO_HUMAN (1446-1666): 1.18e-29: 131: 21.37
+	Hs
		128818 MYH9_HUMAN (21-480): 5.51e-17: 88.6: 10.13		P3C2A_HUMAN (1538-1664): 1.27e-23: 111: 27.48
+	Hs
		522636 MYH7_HUMAN (15-674): 5.44e-29: 127: 10.60		SYT3_HUMAN (744-864): 1.76e-09: 64.7: 36.29
+	Hs
		1309697 MYH4_HUMAN (23-689): 1.7e-28: 126: 12.09		SYT3_HUMAN (744-864): 1.76e-09: 64.7: 36.29
+	Ce
		219055 O44490_CAEEL (157-779): 3.4e-16: 85.5: 15.88		RIM_CAEEL (328-867): 1.33e-13: 78.9: 12.57
+	Dm
		397193 MYSN_DROME (498-957): 3.01e-16: 86.3: 13.58		KPC1_DROME (1540-1659): 5.78e-13: 76.1: 29.51
+	Dm
		65153 A8DY79_DROME (166-918): 3.21e-10: 66.7: 12.08		Q9V483_DROME (1458-1669): 3.3e-11: 70.8: 16.74