Protein: TSN2
Tetraspanin-2 (Tspan-2) (Tetraspan NET-3)

Gene: TSN2, TSPAN2
Organism: Homo sapiens
Interactions: 86
UniProt ID: O60636

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005886 - plasma membrane
GO:0006954 - inflammatory response
GO:0014002 - astrocyte development
GO:0014005 - microglia development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

252640

FPRP
Prostaglandin F2 receptor negative regulator

3

20

High-throughput

0.855

High

252570

TSN3
Tetraspanin-3

2

19

High-throughput

0.811

High

252573

TSN15
Tetraspanin-15

2

19

High-throughput

0.811

High

252580

CD63
CD63 antigen

2

19

High-throughput

0.811

High

252595

TSN31
Tetraspanin-31

2

3

High-throughput

0.783

High

252638

SCN3B
Sodium channel regulatory subunit beta-3

2

8

High-throughput

0.783

High

252634

VISTA
V-type immunoglobulin domain-containing suppressor of T-cell activation

2

0

High-throughput

0.742

High

252583

CD9
CD9 antigen

1

19

High-throughput

0.691

High

252587

CD151
CD151 antigen

1

18

High-throughput

0.691

High

252590

GRB2
Growth factor receptor-bound protein 2

2

4

High-throughput

0.663

High

252571

PRAF3
PRA1 family protein 3

2

4

High-throughput

0.628

High

252582

LEG3
Galectin-3

2

8

High-throughput

0.628

High

252614

F241A
Uncharacterized protein FAM241A

2

2

High-throughput

0.628

High

252615

DGLB
Diacylglycerol lipase-beta

2

3

High-throughput

0.628

High

252639

MTCH1
Mitochondrial carrier homolog 1

2

1

High-throughput

0.628

High

225349

ERD23
ER lumen protein-retaining receptor 3

3

1

High-throughput

0.607

High

138547

CLD5
Claudin-5

2

6

High-throughput

0.606

High

166823

MGST3
Glutathione S-transferase 3, mitochondrial

2

4

High-throughput

0.606

High

252581

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

1

High-throughput

0.606

High

252585

INGR2
Interferon gamma receptor 2

2

1

High-throughput

0.606

High

252604

ZFY27
Protrudin

2

1

High-throughput

0.606

High

252611

ZNT8
Proton-coupled zinc antiporter SLC30A8

2

6

High-throughput

0.606

High

252620

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

6

High-throughput

0.606

High

252625

DCBD2
Discoidin, CUB and LCCL domain-containing protein 2

2

4

High-throughput

0.606

High

252635

S35C2
Solute carrier family 35 member C2

2

2

High-throughput

0.606

High

252642

AT1B4
Protein ATP1B4

2

7

High-throughput

0.606

High

252600

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

3

5

High-throughput

0.604

High

252644

SNX14
Sorting nexin-14

3

7

High-throughput

0.604

High

252645

SNX13
Sorting nexin-13

3

9

High-throughput

0.604

High

252617

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

3

High-throughput

0.584

High

181211

PGRC2
Membrane-associated progesterone receptor component 2

2

0

High-throughput

0.580

High

252572

LERL1
Leptin receptor overlapping transcript-like 1

2

0

High-throughput

0.580

High

252574

ABHGA
Phosphatidylserine lipase ABHD16A

2

0

High-throughput

0.580

High

252599

SOAT
Sodium-dependent organic anion transporter

2

0

High-throughput

0.580

High

252613

TM130
Transmembrane protein 130

2

0

High-throughput

0.580

High

230223

CREB3
Cyclic AMP-responsive element-binding protein 3

2

6

High-throughput

0.576

High

252619

IGSF8
Immunoglobulin superfamily member 8

1

20

High-throughput

0.575

High

252623

REEP6
Receptor expression-enhancing protein 6

2

9

High-throughput

0.574

High

252633

ZDHC6
Palmitoyltransferase ZDHHC6

2

12

High-throughput

0.574

High

252622

BSCL2
Seipin

2

3

High-throughput

0.560

High

252601

F209A
Protein FAM209A

2

4

High-throughput

0.553

High

252607

RN19B
E3 ubiquitin-protein ligase RNF19B

2

1

High-throughput

0.553

High

252609

CLC14
C-type lectin domain family 14 member A

2

7

High-throughput

0.553

High

252630

MFF
Mitochondrial fission factor

2

1

High-throughput

0.553

High

252632

REEP4
Receptor expression-enhancing protein 4

2

9

High-throughput

0.553

High

252643

TMX2
Thioredoxin-related transmembrane protein 2

2

1

High-throughput

0.553

High

252646

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

2

2

High-throughput

0.553

High

252576

FOS
Protein c-Fos

1

6

High-throughput

0.541

High

252592

IFM3
Interferon-induced transmembrane protein 3

1

5

High-throughput

0.536

High

252593

KDSR
3-ketodihydrosphingosine reductase

1

10

High-throughput

0.536

High

252597

RAB35
Ras-related protein Rab-35

1

2

High-throughput

0.536

High

252598

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

1

4

High-throughput

0.536

High

252605

MBOA5
Lysophospholipid acyltransferase 5

1

4

High-throughput

0.536

High

252606

LCLT1
Lysocardiolipin acyltransferase 1

1

14

High-throughput

0.536

High

252616

PIEZ1
Piezo-type mechanosensitive ion channel component 1

1

2

High-throughput

0.536

High

252621

F241B
Protein FAM241B

1

4

High-throughput

0.536

High

252626

SGMR1
Sigma non-opioid intracellular receptor 1

1

2

High-throughput

0.536

High

252577

CRYAA
Alpha-crystallin A chain

1

1

High-throughput

0.515

High

252584

FGFR3
Fibroblast growth factor receptor 3

1

6

High-throughput

0.515

High

252588

HSP72
Heat shock-related 70 kDa protein 2

1

2

High-throughput

0.515

High

252618

KLK6
Kallikrein-6

1

2

High-throughput

0.515

High

252641

UBQL1
Ubiquilin-1

1

1

High-throughput

0.515

High

252589

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.513

High

252596

TMED1
Transmembrane emp24 domain-containing protein 1

1

0

High-throughput

0.513

High

252629

TTYH3
Protein tweety homolog 3

1

0

High-throughput

0.513

High

167200

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.493

High

252579

GELS
Gelsolin

1

0

High-throughput

0.493

High

252591

REEP5
Receptor expression-enhancing protein 5

1

9

High-throughput

0.489

High

252612

VKORL
Vitamin K epoxide reductase complex subunit 1-like protein 1

1

6

High-throughput

0.489

High

252636

ABCBA
ATP-binding cassette sub-family B member 10, mitochondrial

1

2

High-throughput

0.489

High

252578

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

5

High-throughput

0.481

High

116991

J3KQ12
Seipin

1

3

High-throughput

0.470

High

252575

F13A
Coagulation factor XIII A chain

1

1

High-throughput

0.470

High

252594

Q0VDC6
peptidylprolyl isomerase

1

2

High-throughput

0.470

High

252610

Q86V38
Atrophin 1

1

1

High-throughput

0.470

High

252602

TMM31
Transmembrane protein 31

1

0

High-throughput

0.460

High

252627

FAP24
Fanconi anemia core complex-associated protein 24

1

0

High-throughput

0.426

High

252631

GOLP3
Golgi phosphoprotein 3

1

0

High-throughput

0.426

High

252586

GPDM
Glycerol-3-phosphate dehydrogenase, mitochondrial

1

3

High-throughput

0.407

High

252637

TM14B
Transmembrane protein 14B

2

0

High-throughput

0.316

High

163528

TPP1
Tripeptidyl-peptidase 1

1

0

High-throughput

0.279

Low

252624

F167A
Protein FAM167A

1

0

High-throughput

0.279

Low

252628

NUP58
Nucleoporin p58/p45

1

0

High-throughput

0.268

Low

252603

RBG1L
Rab GTPase-activating protein 1-like

1

0

High-throughput

0.257

Low

85222

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

High-throughput

0.251

Low

252608

LYG2
Lysozyme g-like protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025