HitPredict

Interactor 1: ARHGB (O15085)
Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF)
Gene: ARHGEF11

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.975

Property	Details
Experiments	28514442, 32203420, 10526156, 33961781, 31871319, 21988832, 15530360, 34591642, 20300064
Identification Methods	affinity chromatography technology, pull down, fluorescent resonance energy transfer, enzymatic study, two hybrid, gdp/gtp exchange assay, molecular sieving, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PDZ~Ras, PH_16~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007266 - Rho protein signal transduction GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1522 Hs			1 193
+	Hs
		167081 ARHGB_HUMAN (1-1522): 0: 936: 100.00		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		167063 ARHGB_HUMAN (1-1522): 0: 936: 100.00		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		167077 ARHGB_HUMAN (1-1522): 0: 936: 100.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		167079 ARHGB_HUMAN (1-1522): 0: 936: 100.00		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		900985 ARHGC_HUMAN (6-1457): 0: 596: 29.71		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		436545 ARHGC_HUMAN (6-1457): 0: 596: 29.71		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		894523 ARHGC_HUMAN (6-1457): 0: 596: 29.71		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		892637 ARHGC_HUMAN (6-1457): 0: 596: 29.71		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		916029 ARHGC_HUMAN (6-1457): 0: 596: 29.71		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		901085 FARP1_HUMAN (205-1177): 4.41e-119: 402: 14.95		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		925760 FARP1_HUMAN (205-1177): 4.41e-119: 402: 14.95		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		436587 FARP1_HUMAN (205-1177): 4.41e-119: 402: 14.95		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		951489 FARP1_HUMAN (205-1177): 4.41e-119: 402: 14.95		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		894619 FARP1_HUMAN (205-1177): 4.41e-119: 402: 14.95		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		545718 FARP1_HUMAN (205-1177): 4.41e-119: 402: 14.95		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		901037 VAV3_HUMAN (553-1281): 6.21e-116: 388: 15.46		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		892698 FARP1_HUMAN (205-1177): 4.41e-119: 402: 14.95		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		925718 VAV3_HUMAN (553-1281): 6.21e-116: 388: 15.46		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		916095 FARP1_HUMAN (205-1177): 4.41e-119: 402: 14.95		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		120731 FARP1_HUMAN (205-1177): 4.41e-119: 402: 14.95		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98