Protein: GEMI2
Gem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1)

Gene: GEMI2, GEMIN2
Organism: Homo sapiens
Interactions: 114
UniProt ID: O14893

Gene Ontology (top 5):
GO:0000245 - spliceosomal complex assembly
GO:0000375 - RNA splicing, via transesterification reactions
GO:0000387 - spliceosomal snRNP assembly
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

167091

SMN
Survival motor neuron protein

19

2

Small-scale

0.989

High

167075

RUXF
Small nuclear ribonucleoprotein F

8

4

Small-scale

0.968

High

167074

RUXE
Small nuclear ribonucleoprotein E

5

0

Small-scale

0.869

High

167081

RSMN
Small nuclear ribonucleoprotein-associated protein N

3

1

Small-scale

0.866

High

167078

SMD1
Small nuclear ribonucleoprotein Sm D1

3

3

Small-scale

0.855

High

167076

RUXG
Small nuclear ribonucleoprotein G

3

9

Small-scale

0.839

High

167079

SMD2
Small nuclear ribonucleoprotein Sm D2

3

1

Small-scale

0.839

High

167056

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

1

High-throughput

0.811

High

167077

LSM6
U6 snRNA-associated Sm-like protein LSm6

2

4

High-throughput

0.811

High

167134

DDX20
Probable ATP-dependent RNA helicase DDX20

8

1

Small-scale

0.750

High

167050

RU17
U1 small nuclear ribonucleoprotein 70 kDa

6

0

Small-scale

0.699

High

167136

LSM7
U6 snRNA-associated Sm-like protein LSm7

1

9

High-throughput

0.691

High

167125

GEMI7
Gem-associated protein 7

5

0

Small-scale

0.688

High

167109

GEMI6
Gem-associated protein 6

5

0

Small-scale

0.684

High

167128

GEMI8
Gem-associated protein 8

5

0

Small-scale

0.684

High

167131

SPN90
NCK-interacting protein with SH3 domain

4

0

High-throughput

0.667

High

167071

GEMI4
Gem-associated protein 4

4

0

Small-scale

0.664

High

167141

STRAP
Serine-threonine kinase receptor-associated protein

4

0

Small-scale

0.664

High

167080

ACTA
Actin, aortic smooth muscle

2

1

High-throughput

0.628

High

167108

GEMI5
Gem-associated protein 5

3

0

Small-scale

0.628

High

167040

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

6

High-throughput

0.618

High

167140

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

4

High-throughput

0.618

High

167060

HXD10
Homeobox protein Hox-D10

2

1

High-throughput

0.606

High

167069

MEOX1
Homeobox protein MOX-1

2

1

High-throughput

0.606

High

167102

PNKD
Probable thioesterase PNKD

2

0

High-throughput

0.585

High

167042

IMA7
Importin subunit alpha-7

2

0

High-throughput

0.580

High

167044

RPP14
Ribonuclease P protein subunit p14

2

0

High-throughput

0.580

High

167057

PSB1
Proteasome subunit beta type-1

2

0

High-throughput

0.580

High

167059

PAX6
Paired box protein Pax-6

2

0

High-throughput

0.580

High

167086

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

167130

SPG21
Maspardin

2

0

High-throughput

0.580

High

167100

FAM9B
Protein FAM9B

2

0

High-throughput

0.576

High

71539

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

9

High-throughput

0.575

High

167127

STRN4
Striatin-4

2

1

High-throughput

0.574

High

167047

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

167143

NEMO
NF-kappa-B essential modulator

1

0

High-throughput

0.537

High

167051

SNRPA
U1 small nuclear ribonucleoprotein A

1

1

High-throughput

0.536

High

167052

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.536

High

167063

FUS
RNA-binding protein FUS

1

1

High-throughput

0.536

High

167092

P3H1
Prolyl 3-hydroxylase 1

1

1

High-throughput

0.536

High

167116

HDA11
Histone deacetylase 11

1

1

High-throughput

0.536

High

167112

RAD50
DNA repair protein RAD50

1

0

Small-scale

0.529

High

67408

GOG8A
Golgin subfamily A member 8A

1

0

High-throughput

0.513

High

167054

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

167068

CLK3
Dual specificity protein kinase CLK3

1

0

High-throughput

0.513

High

167083

BAX
Apoptosis regulator BAX

1

0

High-throughput

0.513

High

167085

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.513

High

167089

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

167113

FGF14
Fibroblast growth factor 14

1

0

High-throughput

0.513

High

167118

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

0

High-throughput

0.513

High

167119

ERMAP
Erythroid membrane-associated protein

1

0

High-throughput

0.513

High

167133

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

0

High-throughput

0.513

High

167053

LEG1
Galectin-1

1

0

Small-scale

0.493

High

167090

RNPS1
RNA-binding protein with serine-rich domain 1

1

0

High-throughput

0.493

High

167043

CRTAP
Cartilage-associated protein

1

1

High-throughput

0.489

High

167093

ACTBL
Beta-actin-like protein 2

1

1

High-throughput

0.489

High

167135

NUFP1
FMR1-interacting protein NUFIP1

1

0

Small-scale

0.480

High

167142

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

167111

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

167037

GEMI2
Gem-associated protein 2

1

0

High-throughput

0.460

High

128615

MEN1
Menin

1

0

High-throughput

0.458

High

164172

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

167039

XPO1
Exportin-1

1

0

High-throughput

0.458

High

167041

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.458

High

167045

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

167048

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

167058

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

Small-scale

0.458

High

167062

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.458

High

167064

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

167067

SRP09
Signal recognition particle 9 kDa protein

1

0

Small-scale

0.458

High

167070

COPA
Coatomer subunit alpha

1

0

Small-scale

0.458

High

167072

SRP54
Signal recognition particle subunit SRP54

1

0

Small-scale

0.458

High

167073

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

167082

VIGLN
Vigilin

1

0

High-throughput

0.458

High

167084

DHX9
ATP-dependent RNA helicase A

1

0

Small-scale

0.458

High

167088

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.458

High

167098

TAXB1
Tax1-binding protein 1

1

0

High-throughput

0.458

High

167107

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

167110

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

167114

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

0

Small-scale

0.458

High

167115

PF21A
PHD finger protein 21A

1

0

High-throughput

0.458

High

167117

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

167120

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

167121

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

167122

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

167124

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

167126

SMYD2
N-lysine methyltransferase SMYD2

1

0

High-throughput

0.458

High

167129

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

0

Small-scale

0.458

High

167139

MYO6
Unconventional myosin-VI

1

0

High-throughput

0.458

High

167038

S27A2
Long-chain fatty acid transport protein 2

1

1

High-throughput

0.445

High

167095

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.445

High

167123

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

167046

GLPA
Glycophorin-A

1

0

High-throughput

0.426

High

167138

AGO1
Protein argonaute-1

1

0

High-throughput

0.426

High

167096

S27A1
Long-chain fatty acid transport protein 1

1

1

High-throughput

0.407

High

167099

CMTD1
Catechol O-methyltransferase domain-containing protein 1

3

0

High-throughput

0.347

High

167049

ACM4
Muscarinic acetylcholine receptor M4

2

0

High-throughput

0.328

High

167104

SIGL1
SIGLEC family-like protein 1

2

0

High-throughput

0.328

High

167103

BEND7
BEN domain-containing protein 7

2

0

High-throughput

0.316

High

167055

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.279

Low

167065

GLR
Glucagon receptor

1

0

High-throughput

0.279

Low

167087

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

0

High-throughput

0.279

Low

167094

FAXC
Failed axon connections homolog

1

0

High-throughput

0.279

Low

167101

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

0

High-throughput

0.279

Low

167106

CERK1
Ceramide kinase

1

0

High-throughput

0.279

Low

167132

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

167066

MTR1A
Melatonin receptor type 1A

1

0

High-throughput

0.265

Low

167061

PROF2
Profilin-2

1

0

High-throughput

0.249

Low

167097

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.249

Low

50441

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.232

Low

166212

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.232

Low

167105

IQUB
IQ motif and ubiquitin-like domain-containing protein

1

0

High-throughput

0.232

Low

167137

ANGL2
Angiopoietin-related protein 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025