HitPredict

Interactor 1: SMAD7 (O15105)
Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7) (hSMAD7)
Gene: SMAD7

Interactor 2: AXIN1 (O15169)
Axin-1 (Axis inhibition protein 1) (hAxin)
Gene: AXIN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

The method score is based on:

Property	Details
Experiments	18593713, 16601693
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008013 - beta-catenin binding and 4 others more... GO:0031625 - ubiquitin protein ligase binding GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0070411 - I-SMAD binding GO:1990756 - ubiquitin-like ligase-substrate adaptor activity
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	426
Hs

1	862

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024