HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	24720748
Identification Methods	far western blotting, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 372
+	Hs
		453436 MARK2_HUMAN (12-724): 1.19e-142: 439: 15.92		ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00
+	Hs
		453685 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00
+	Hs
		453153 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00
+	Hs
		453680 KS6B2_HUMAN (15-419): 1.39e-115: 359: 21.24		ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00
+	Hs
		610090 KS6B2_HUMAN (15-419): 1.39e-115: 359: 21.24		ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00
+	Hs
		625400 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98
+	Hs
		1031324 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		PABP4_HUMAN (102-190): 3.52e-15: 79: 15.56
+	Hs
		625424 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		HNRPD_HUMAN (2-101): 4.8e-18: 86.4: 31.00
+	Dm
		1213421 AKT1_DROME (3-371): 1.03e-88: 293: 22.58		MSIR6_DROME (2-92): 3.51e-17: 83.7: 38.46
+	Hs
		568649 KAPCA_HUMAN (3-316): 7.79e-90: 287: 27.41		PABP4_HUMAN (102-190): 3.52e-15: 79: 15.56
+	Mm
		857308 KAPCB_MOUSE (2-316): 5.88e-89: 284: 27.47		TIA1_MOUSE (99-193): 5.17e-09: 59.4: 17.71
+	Hs
		609952 ULK2_HUMAN (15-221): 2.42e-28: 124: 36.28		ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00
+	Hs
		161966 MARK3_HUMAN (13-221): 1.13e-24: 112: 35.05		HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41
+	Dm
		1228778 Q8MQJ7_DROME (15-221): 1.8e-26: 117: 33.18		MSIR6_DROME (2-92): 3.51e-17: 83.7: 38.46