Protein: PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL)

Gene: PP6R3, PPP6R3
Organism: Homo sapiens
Interactions: 180
UniProt ID: Q5H9R7

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0009966 - regulation of signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

143643

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

12

9

Small-scale

0.759

High

170179

AURKA
Aurora kinase A

8

4

High-throughput

0.750

High

177235

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

3

10

Small-scale

0.671

High

920013

PLK1
Serine/threonine-protein kinase PLK1

3

10

High-throughput

0.656

High

1204753

GPSM1
G-protein-signaling modulator 1

3

3

Small-scale

0.656

High

1204763

ANR44
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

5

10

High-throughput

0.650

High

799189

BRCA1
Breast cancer type 1 susceptibility protein

3

4

High-throughput

0.640

High

1204758

TRM2A
tRNA

2

2

High-throughput

0.628

High

1204748

MOB1B
MOB kinase activator 1B

2

8

High-throughput

0.611

High

1204802

MOB1A
MOB kinase activator 1A

2

8

High-throughput

0.611

High

1204822

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

2

6

High-throughput

0.611

High

988989

AP2B1
AP-2 complex subunit beta

2

14

High-throughput

0.595

High

891600

GSK3B
Glycogen synthase kinase-3 beta

2

10

High-throughput

0.584

High

1131046

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

2

4

High-throughput

0.584

High

1204813

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.573

High

396263

ESR1
Estrogen receptor

2

10

High-throughput

0.571

High

1204765

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

2

10

High-throughput

0.567

High

1008185

PRKDC
DNA-dependent protein kinase catalytic subunit

1

6

Small-scale

0.561

High

354714

PAK4
Serine/threonine-protein kinase PAK 4

1

1

High-throughput

0.536

High

407100

HG2A
HLA class II histocompatibility antigen gamma chain

1

1

High-throughput

0.536

High

469795

CATG
Cathepsin G

1

3

High-throughput

0.536

High

563870

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.536

High

721014

CLIP1
CAP-Gly domain-containing linker protein 1

1

1

High-throughput

0.536

High

857474

NOTC1
Neurogenic locus notch homolog protein 1

1

11

High-throughput

0.536

High

885801

KC1E
Casein kinase I isoform epsilon

1

2

High-throughput

0.536

High

930718

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

6

High-throughput

0.536

High

1091186

FOXD4
Forkhead box protein D4

1

4

High-throughput

0.536

High

1142071

P2RY6
P2Y purinoceptor 6

1

6

High-throughput

0.536

High

1187834

FX4L6
Forkhead box protein D4-like 6

1

4

High-throughput

0.536

High

1204747

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

4

High-throughput

0.536

High

1204768

ARRD4
Arrestin domain-containing protein 4

1

6

High-throughput

0.536

High

1204772

ARRD2
Arrestin domain-containing protein 2

1

6

High-throughput

0.536

High

1204779

HDA11
Histone deacetylase 11

1

12

High-throughput

0.536

High

1204805

E41L5
Band 4.1-like protein 5

1

4

High-throughput

0.536

High

1204808

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.536

High

1204812

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

3

High-throughput

0.536

High

1204815

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

1

High-throughput

0.536

High

1204820

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

3

High-throughput

0.536

High

1204793

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.529

High

1204791

SH3G3
Endophilin-A3

2

20

High-throughput

0.521

High

830862

CCNF
Cyclin-F

1

2

High-throughput

0.515

High

1204777

ARHG2
Rho guanine nucleotide exchange factor 2

1

4

Small-scale

0.515

High

274610

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.513

High

905589

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.513

High

946132

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.513

High

1132158

ICAM4
Intercellular adhesion molecule 4

1

0

High-throughput

0.513

High

1204757

DDX60
Probable ATP-dependent RNA helicase DDX60

1

0

High-throughput

0.513

High

1204800

SENP3
Sentrin-specific protease 3

1

0

High-throughput

0.513

High

349114

LATS1
Serine/threonine-protein kinase LATS1

1

2

Small-scale

0.501

High

508092

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.501

High

464981

SP1
Transcription factor Sp1

1

2

High-throughput

0.500

High

1204774

SP7
Transcription factor Sp7

1

2

High-throughput

0.500

High

143740

WN10B
Protein Wnt-10b

1

4

High-throughput

0.489

High

483675

WNT2
Protein Wnt-2

1

4

High-throughput

0.489

High

567878

PRG2
Bone marrow proteoglycan

1

2

High-throughput

0.489

High

914629

RM12
Large ribosomal subunit protein bL12m

1

1

High-throughput

0.489

High

1204778

EMID1
EMI domain-containing protein 1

1

1

High-throughput

0.489

High

662591

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

0

High-throughput

0.479

High

58728

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

5

High-throughput

0.479

High

127785

IKBE
NF-kappa-B inhibitor epsilon

1

15

High-throughput

0.479

High

172899

XPO1
Exportin-1

1

12

High-throughput

0.479

High

194573

KDM6A
Lysine-specific demethylase 6A

1

1

Small-scale

0.479

High

218268

TGON2
Trans-Golgi network integral membrane protein 2

1

7

High-throughput

0.479

High

241895

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

269963

AUXI
Auxilin

1

4

High-throughput

0.479

High

273674

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

10

High-throughput

0.479

High

279384

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

315664

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

319819

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

321255

ERLN2
Erlin-2

1

1

High-throughput

0.479

High

323733

AP2A2
AP-2 complex subunit alpha-2

1

15

High-throughput

0.479

High

344708

AP2A1
AP-2 complex subunit alpha-1

1

15

High-throughput

0.479

High

412049

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.479

High

537288

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

639254

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

5

High-throughput

0.479

High

731371

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

762010

GRK5
G protein-coupled receptor kinase 5

1

3

High-throughput

0.479

High

767059

PTN7
Tyrosine-protein phosphatase non-receptor type 7

1

1

High-throughput

0.479

High

791438

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

849005

PTN9
Tyrosine-protein phosphatase non-receptor type 9

1

1

High-throughput

0.479

High

891185

GSK3A
Glycogen synthase kinase-3 alpha

1

10

High-throughput

0.479

High

896198

MXI1
Max-interacting protein 1

1

2

Small-scale

0.479

High

970618

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

986466

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.479

High

1004661

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1032005

TFAP4
Transcription factor AP-4

1

1

Small-scale

0.479

High

1045367

TF65
Transcription factor p65

1

2

High-throughput

0.479

High

1083247

AP1B1
AP-1 complex subunit beta-1

1

14

High-throughput

0.479

High

1092556

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

1

High-throughput

0.479

High

1107796

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

1109791

HDAC1
Histone deacetylase 1

1

10

Small-scale

0.479

High

1110870

IRF5
Interferon regulatory factor 5

1

1

High-throughput

0.479

High

1113289

CUL3
Cullin-3

1

3

High-throughput

0.479

High

1122504

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

9

High-throughput

0.479

High

1135700

HAPR1
HUWE1-associated protein modifying stress responses 1

1

2

High-throughput

0.479

High

1138288

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1140382

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1156507

CCDC6
Coiled-coil domain-containing protein 6

1

5

High-throughput

0.479

High

1178169

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1204736

TENS2
Tensin-2

1

4

High-throughput

0.479

High

1204743

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1204746

ACD11
Acyl-CoA dehydrogenase family member 11

1

2

High-throughput

0.479

High

1204749

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1204750

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

High-throughput

0.479

High

1204751

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

1204759

STK40
Serine/threonine-protein kinase 40

1

6

Small-scale

0.479

High

1204762

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

High-throughput

0.479

High

1204766

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

1204770

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

2

Small-scale

0.479

High

1204773

BRSK1
Serine/threonine-protein kinase BRSK1

1

7

High-throughput

0.479

High

1204776

HDAC2
Histone deacetylase 2

1

10

Small-scale

0.479

High

1204780

AURKB
Aurora kinase B

1

3

High-throughput

0.479

High

1204785

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

1

High-throughput

0.479

High

1204787

RB40C
Ras-related protein Rab-40C

1

5

Small-scale

0.479

High

1204789

RING2
E3 ubiquitin-protein ligase RING2

1

8

High-throughput

0.479

High

1204790

DNJC2
DnaJ homolog subfamily C member 2

1

3

High-throughput

0.479

High

1204795

CEP44
Centrosomal protein of 44 kDa

1

1

High-throughput

0.479

High

1204796

WWTR1
WW domain-containing transcription regulator protein 1

1

3

High-throughput

0.479

High

1204798

DUS15
Dual specificity protein phosphatase 15

1

1

High-throughput

0.479

High

1204799

TXNIP
Thioredoxin-interacting protein

1

6

Small-scale

0.479

High

1204801

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1204803

ECT2
Protein ECT2

1

5

High-throughput

0.479

High

1204806

MYO10
Unconventional myosin-X

1

4

Small-scale

0.479

High

1204807

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

3

High-throughput

0.479

High

1204811

DJC11
DnaJ homolog subfamily C member 11

1

5

High-throughput

0.479

High

1204816

KS6B2
Ribosomal protein S6 kinase beta-2

1

4

High-throughput

0.479

High

1204817

TES
Testin

1

2

High-throughput

0.479

High

1204821

FZR1
Fizzy-related protein homolog

1

2

High-throughput

0.479

High

1204824

DUS10
Dual specificity protein phosphatase 10

1

3

High-throughput

0.479

High

130123

PGRC1
Membrane-associated progesterone receptor component 1

1

0

Small-scale

0.458

High

221798

SNAI2
Zinc finger protein SNAI2

1

0

Small-scale

0.458

High

376848

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.458

High

693779

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.458

High

766615

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

957941

RAB14
Ras-related protein Rab-14

1

0

High-throughput

0.458

High

1040827

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

High-throughput

0.458

High

1204738

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.458

High

1204740

ZN746
Zinc finger protein 746

1

0

High-throughput

0.458

High

1204744

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

1204760

HROB
Homologous recombination OB-fold protein

1

0

Small-scale

0.458

High

1204764

ZBT38
Zinc finger and BTB domain-containing protein 38

1

0

Small-scale

0.458

High

1204771

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.458

High

1204783

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

1204784

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1204786

FMNL2
Formin-like protein 2

1

0

High-throughput

0.458

High

1204794

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1204797

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1204814

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

140298

SDCB1
Syntenin-1

1

5

High-throughput

0.445

High

166312

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

3

High-throughput

0.445

High

171468

S27A2
Long-chain fatty acid transport protein 2

1

6

High-throughput

0.445

High

987683

GRB2
Growth factor receptor-bound protein 2

1

13

High-throughput

0.445

High

1204735

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

1204737

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.445

High

1204741

S27A4
Long-chain fatty acid transport protein 4

1

6

High-throughput

0.445

High

1204742

S27A1
Long-chain fatty acid transport protein 1

1

6

High-throughput

0.445

High

1204755

SPNS2
Sphingosine-1-phosphate transporter SPNS2

1

1

High-throughput

0.445

High

1204767

MOT11
Monocarboxylate transporter 11

1

2

High-throughput

0.445

High

1204769

BBS1
BBSome complex member BBS1

1

1

High-throughput

0.445

High

1204782

TNIP3
TNFAIP3-interacting protein 3

1

3

High-throughput

0.445

High

1204792

S39A3
Zinc transporter ZIP3

1

1

High-throughput

0.445

High

1204809

S22AB
Solute carrier family 22 member 11

1

2

High-throughput

0.445

High

1204810

S39A9
Zinc transporter ZIP9

1

1

High-throughput

0.445

High

1204823

XCT
Cystine/glutamate transporter

1

1

High-throughput

0.445

High

293798

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

1204745

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

1204752

HOOK3
Protein Hook homolog 3

1

3

High-throughput

0.437

High

1204756

BRSK2
Serine/threonine-protein kinase BRSK2

1

7

High-throughput

0.437

High

1204761

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

1204818

DS13B
Dual specificity protein phosphatase 13B

1

3

High-throughput

0.437

High

1204819

HOOK1
Protein Hook homolog 1

1

3

High-throughput

0.437

High

1204804

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

1064

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.407

High

167450

WNT9A
Protein Wnt-9a

1

4

High-throughput

0.407

High

1144245

PGFRL
Platelet-derived growth factor receptor-like protein

1

1

High-throughput

0.407

High

1204739

S35E4
Solute carrier family 35 member E4

1

2

High-throughput

0.407

High

1204775

NET5
Netrin-5

1

2

High-throughput

0.407

High

1204754

FABD
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

1

0

High-throughput

0.279

Low

1204781

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1204788

GPHA2
Glycoprotein hormone alpha-2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025