Protein: PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2 (SAPS domain family member 2)

Gene: PP6R2, PPP6R2
Organism: Homo sapiens
Interactions: 124
UniProt ID: O75170

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0009966 - regulation of signal transduction
GO:0019888 - protein phosphatase regulator activity
GO:0019903 - protein phosphatase binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

143508

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

10

12

Small-scale

0.758

High

273656

PLK1
Serine/threonine-protein kinase PLK1

9

13

Small-scale

0.757

High

169846

AURKA
Aurora kinase A

6

6

High-throughput

0.733

High

177150

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

5

14

Small-scale

0.723

High

273661

PRKDC
DNA-dependent protein kinase catalytic subunit

3

8

Small-scale

0.681

High

273666

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

3

4

High-throughput

0.667

High

273690

ANR44
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

5

14

High-throughput

0.650

High

273691

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

4

14

High-throughput

0.645

High

140079

SDCB1
Syntenin-1

3

11

Small-scale

0.641

High

69747

ZN785
Zinc finger protein 785

2

2

High-throughput

0.628

High

171373

S27A2
Long-chain fatty acid transport protein 2

2

7

High-throughput

0.628

High

225755

AP1G1
AP-1 complex subunit gamma-1

2

16

High-throughput

0.628

High

273659

AP1S2
AP-1 complex subunit sigma-2

2

8

High-throughput

0.628

High

273664

AP1B1
AP-1 complex subunit beta-1

2

15

High-throughput

0.628

High

273672

KCC4
Calcium/calmodulin-dependent protein kinase type IV

2

3

High-throughput

0.628

High

273680

ACD11
Acyl-CoA dehydrogenase family member 11

2

3

High-throughput

0.628

High

273687

TRM2A
tRNA

2

2

High-throughput

0.628

High

273688

ASPM
Abnormal spindle-like microcephaly-associated protein

2

8

High-throughput

0.628

High

273734

MYO5A
Unconventional myosin-Va

2

5

High-throughput

0.628

High

273684

MOB1B
MOB kinase activator 1B

2

9

High-throughput

0.621

High

273700

AP2M1
AP-2 complex subunit mu

2

2

High-throughput

0.611

High

273715

MOB1A
MOB kinase activator 1A

2

9

High-throughput

0.611

High

273678

ZN574
Zinc finger protein 574

2

0

High-throughput

0.602

High

273692

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

2

0

High-throughput

0.602

High

273644

PIP
Prolactin-inducible protein

2

1

High-throughput

0.601

High

273705

DCR1C
Protein artemis

3

1

High-throughput

0.599

High

127746

IKBE
NF-kappa-B inhibitor epsilon

2

19

Small-scale

0.584

High

273724

ZRAN1
Ubiquitin thioesterase ZRANB1

2

7

High-throughput

0.584

High

273646

GDC
Solute carrier family 25 member 16

2

4

High-throughput

0.574

High

273697

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

2

1

High-throughput

0.574

High

273717

MYO5C
Unconventional myosin-Vc

2

5

High-throughput

0.574

High

273728

MYO5B
Unconventional myosin-Vb

2

4

High-throughput

0.574

High

230727

EXTL3
Exostosin-like 3

1

1

High-throughput

0.536

High

239288

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

12

High-throughput

0.536

High

254317

CC14B
Dual specificity protein phosphatase CDC14B

1

7

High-throughput

0.536

High

273638

AP2A1
AP-2 complex subunit alpha-1

1

16

High-throughput

0.536

High

273651

SRP14
Signal recognition particle 14 kDa protein

1

1

High-throughput

0.536

High

273653

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

2

High-throughput

0.536

High

273654

KS6A3
Ribosomal protein S6 kinase alpha-3

1

4

High-throughput

0.536

High

273673

FX4L6
Forkhead box protein D4-like 6

1

5

High-throughput

0.536

High

273694

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

2

High-throughput

0.536

High

273699

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.536

High

273709

NPAS1
Neuronal PAS domain-containing protein 1

1

5

High-throughput

0.536

High

273730

ABT1
Activator of basal transcription 1

1

1

High-throughput

0.536

High

143719

WN10B
Protein Wnt-10b

2

4

High-throughput

0.521

High

273696

ARHG2
Rho guanine nucleotide exchange factor 2

1

6

Small-scale

0.515

High

273652

HD
Huntingtin

1

5

High-throughput

0.515

High

273713

S26A6
Solute carrier family 26 member 6

1

0

High-throughput

0.513

High

273658

ATX1
Ataxin-1

1

1

High-throughput

0.508

High

273640

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

50456

HACL2
2-hydroxyacyl-CoA lyase 2

1

2

High-throughput

0.489

High

273635

MYO1D
Unconventional myosin-Id

1

5

High-throughput

0.489

High

273637

ACSL3
Fatty acid CoA ligase Acsl3

1

3

High-throughput

0.489

High

273643

WNT2
Protein Wnt-2

1

4

High-throughput

0.489

High

273655

RM12
Large ribosomal subunit protein bL12m

1

1

High-throughput

0.489

High

273681

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

6

High-throughput

0.489

High

273698

EMID1
EMI domain-containing protein 1

1

1

High-throughput

0.489

High

124696

AIP
AH receptor-interacting protein

1

2

High-throughput

0.479

High

172324

XPO1
Exportin-1

1

17

High-throughput

0.479

High

240266

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

273633

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

273634

RECQ4
ATP-dependent DNA helicase Q4

1

8

High-throughput

0.479

High

273636

EPM2A
Laforin

1

1

High-throughput

0.479

High

273641

K2C8
Keratin, type II cytoskeletal 8

1

3

High-throughput

0.479

High

273642

PROF1
Profilin-1

1

4

High-throughput

0.479

High

273648

MARK3
MAP/microtubule affinity-regulating kinase 3

1

6

High-throughput

0.479

High

273649

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

273660

AP2B1
AP-2 complex subunit beta

1

16

High-throughput

0.479

High

273663

ACK1
Activated CDC42 kinase 1

1

13

High-throughput

0.479

High

273665

CUL3
Cullin-3

1

10

High-throughput

0.479

High

273668

KS6A2
Ribosomal protein S6 kinase alpha-2

1

6

High-throughput

0.479

High

273669

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

High-throughput

0.479

High

273670

ZYX
Zyxin

1

4

High-throughput

0.479

High

273671

CCDC6
Coiled-coil domain-containing protein 6

1

7

High-throughput

0.479

High

273674

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

10

High-throughput

0.479

High

273675

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

273682

MOB3C
MOB kinase activator 3C

1

9

High-throughput

0.479

High

273685

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

273689

PNKD
Probable thioesterase PNKD

1

1

High-throughput

0.479

High

273693

NUP43
Nucleoporin Nup43

1

7

High-throughput

0.479

High

273706

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.479

High

273707

DNJC2
DnaJ homolog subfamily C member 2

1

7

High-throughput

0.479

High

273708

TTC1
Tetratricopeptide repeat protein 1

1

6

High-throughput

0.479

High

273714

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

273716

CYBP
Calcyclin-binding protein

1

1

High-throughput

0.479

High

273718

SHLB2
Endophilin-B2

1

15

High-throughput

0.479

High

273719

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

3

High-throughput

0.479

High

273725

TBK1
Serine/threonine-protein kinase TBK1

1

8

High-throughput

0.479

High

273726

PFD2
Prefoldin subunit 2

1

1

High-throughput

0.479

High

273731

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

9

High-throughput

0.479

High

273732

RUVB2
RuvB-like 2

1

2

High-throughput

0.479

High

273733

NUDC
Nuclear migration protein nudC

1

1

High-throughput

0.479

High

273735

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

3

High-throughput

0.479

High

273712

DPCD
Protein DPCD

1

0

High-throughput

0.458

High

273720

HYPK
Huntingtin-interacting protein K

1

0

Small-scale

0.458

High

273722

HTR5B
HEAT repeat-containing protein 5B

1

0

Small-scale

0.458

High

273657

AP2S1
AP-2 complex subunit sigma

1

8

High-throughput

0.445

High

273701

SPTCS
Spatacsin

1

0

Small-scale

0.438

High

104943

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

182063

PFD6
Prefoldin subunit 6

1

1

High-throughput

0.437

High

217606

TGON2
Trans-Golgi network integral membrane protein 2

1

10

High-throughput

0.437

High

273639

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.437

High

273645

PRG2
Bone marrow proteoglycan

1

2

High-throughput

0.437

High

273650

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

273677

FBX42
F-box only protein 42

1

3

High-throughput

0.437

High

273679

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.437

High

273683

MARK2
Serine/threonine-protein kinase MARK2

1

6

High-throughput

0.437

High

273686

HOOK3
Protein Hook homolog 3

1

7

High-throughput

0.437

High

273702

HS12B
Heat shock 70 kDa protein 12B

1

1

High-throughput

0.437

High

273704

RB40C
Ras-related protein Rab-40C

1

6

Small-scale

0.437

High

273721

MARK1
Serine/threonine-protein kinase MARK1

1

5

High-throughput

0.437

High

273727

DS13B
Dual specificity protein phosphatase 13B

1

4

High-throughput

0.437

High

273723

PISD
Phosphatidylserine decarboxylase proenzyme, mitochondrial

1

0

High-throughput

0.426

High

262188

SCN2B
Sodium channel regulatory subunit beta-2

1

1

High-throughput

0.407

High

273647

FPR1
fMet-Leu-Phe receptor

1

2

High-throughput

0.407

High

273662

BAT1
b(0,+)-type amino acid transporter 1

1

1

High-throughput

0.407

High

273667

PGFRL
Platelet-derived growth factor receptor-like protein

1

3

High-throughput

0.407

High

273676

S27A4
Long-chain fatty acid transport protein 4

1

7

High-throughput

0.407

High

273695

NET5
Netrin-5

1

4

High-throughput

0.407

High

273710

GORS1
Golgi reassembly-stacking protein 1

3

0

High-throughput

0.345

High

134205

RPOM
DNA-directed RNA polymerase, mitochondrial

2

0

High-throughput

0.328

High

273711

TMM43
Transmembrane protein 43

1

0

High-throughput

0.279

Low

273703

DAA10
Dynein axonemal assembly factor 10

1

0

High-throughput

0.249

Low

273729

FZD10
Frizzled-10

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025