HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.974

Property	Details
Experiments	11864612, 35271311, 32707033, 21903422, 24189400, 33961781, 25036637, 14743216
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CDC37_M~Pkinase, CDC37_N~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0097110 - scaffold protein binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 378
+	Hs
		158483 IKKB_HUMAN (1-743): 0: 583: 50.87		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1082809 Q59GT1_HUMAN (1-702): 0: 550: 100.00		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1082808 Q59GL9_HUMAN (67-512): 1.14e-131: 400: 56.98		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1083037 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1050208 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		625464 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1083029 KS6B2_HUMAN (15-419): 1.39e-115: 359: 21.24		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		270419 KS6A5_HUMAN (1-314): 1.41e-86: 292: 22.05		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		568678 KAPCA_HUMAN (3-316): 7.79e-90: 287: 27.41		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		70436 B2RB89_HUMAN (5-316): 3.65e-89: 285: 26.96		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		272872 KS6A4_HUMAN (1-402): 3.2e-70: 247: 19.07		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		262278 ULK1_HUMAN (7-221): 7.48e-30: 129: 34.50		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1082863 ULK2_HUMAN (15-221): 2.42e-28: 124: 36.28		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Mm
		250796 ULK1_MOUSE (7-221): 2.26e-30: 130: 34.50		CDC37_MOUSE (1-377): 2.28e-166: 471: 94.97