Protein: MTR1A
Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor)

Gene: MTR1A, MTNR1A
Organism: Homo sapiens
Interactions: 169
UniProt ID: P48039

Gene Ontology (top 5):
GO:0004930 - G protein-coupled receptor activity
GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0007187 - G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007193 - adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

391352

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

3

20

Small-scale

0.866

High

444686

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

3

20

Small-scale

0.866

High

815857

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

2

20

Small-scale

0.819

High

815882

PDIA6
Protein disulfide-isomerase A6

2

4

Small-scale

0.819

High

815927

GBB4
Guanine nucleotide-binding protein subunit beta-4

2

8

Small-scale

0.819

High

815855

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

2

8

Small-scale

0.776

High

653511

CALR
Calreticulin

3

5

Small-scale

0.680

High

815844

MTR1B
Melatonin receptor type 1B

1

17

Small-scale

0.646

High

123536

PGRC1
Membrane-associated progesterone receptor component 1

2

1

Small-scale

0.634

High

151737

IRS4
Insulin receptor substrate 4

2

1

Small-scale

0.634

High

310545

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

5

Small-scale

0.634

High

815852

RAB10
Ras-related protein Rab-10

2

1

Small-scale

0.634

High

815856

RAC1
Ras-related C3 botulinum toxin substrate 1

2

2

Small-scale

0.634

High

815859

RACK1
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.625

High

815849

TMM33
Transmembrane protein 33

3

1

Small-scale

0.621

High

598004

FLNA
Filamin-A

2

12

Small-scale

0.620

High

658212

5HT2C
5-hydroxytryptamine receptor 2C

1

16

Small-scale

0.618

High

670433

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

20

Small-scale

0.618

High

815868

MTR1L
Melatonin-related receptor

1

18

Small-scale

0.618

High

501814

BIP
Endoplasmic reticulum chaperone BiP

2

2

Small-scale

0.601

High

815854

RAP1A
Ras-related protein Rap-1A

2

6

Small-scale

0.601

High

148521

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.587

High

815945

TMX2
Thioredoxin-related transmembrane protein 2

1

0

High-throughput

0.584

High

643965

EF1G
Elongation factor 1-gamma

2

2

Small-scale

0.579

High

654153

CALX
Calnexin

2

5

Small-scale

0.579

High

815865

ROA0
Heterogeneous nuclear ribonucleoprotein A0

2

1

Small-scale

0.579

High

815913

LRC59
Leucine-rich repeat-containing protein 59

2

2

Small-scale

0.579

High

283172

RGS20
Regulator of G-protein signaling 20

1

11

Small-scale

0.561

High

815901

KRA13
Keratin-associated protein 1-3

2

2

High-throughput

0.553

High

815890

Q60FE5
Filamin A

2

15

Small-scale

0.552

High

253887

LRP3
Low-density lipoprotein receptor-related protein 3

1

1

High-throughput

0.541

High

381850

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.541

High

505521

GTR3
Solute carrier family 2, facilitated glucose transporter member 3

1

1

High-throughput

0.541

High

616957

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

3

High-throughput

0.541

High

674112

HMOX2
Heme oxygenase 2

1

3

High-throughput

0.541

High

727959

SOX11
Transcription factor SOX-11

1

1

High-throughput

0.541

High

815861

SC6A3
Sodium-dependent dopamine transporter

1

4

High-throughput

0.541

High

815907

LPP
Lipoma-preferred partner

1

1

High-throughput

0.541

High

815939

PCDBA
Protocadherin beta-10

1

2

High-throughput

0.541

High

173685

SURF4
Surfeit locus protein 4

1

0

High-throughput

0.518

High

602506

COMT
Catechol O-methyltransferase

1

0

High-throughput

0.518

High

617471

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.518

High

815916

CJ090
(E2-independent) E3 ubiquitin-conjugating enzyme FATS

1

0

High-throughput

0.518

High

815860

CAC1B
Voltage-dependent N-type calcium channel subunit alpha-1B

1

1

High-throughput

0.515

High

158604

RGS12
Regulator of G-protein signaling 12

1

11

High-throughput

0.508

High

280034

MPDZ
Multiple PDZ domain protein

1

20

High-throughput

0.508

High

362933

FINC
Fibronectin

1

8

High-throughput

0.508

High

439232

MMP2
72 kDa type IV collagenase

1

5

High-throughput

0.508

High

521496

ACTN1
Alpha-actinin-1

1

4

High-throughput

0.508

High

536066

CD99
CD99 antigen

1

1

High-throughput

0.508

High

716621

CTNA1
Catenin alpha-1

1

2

High-throughput

0.508

High

787866

EPS15
Epidermal growth factor receptor substrate 15

1

3

High-throughput

0.508

High

815851

ACTB
Actin, cytoplasmic 1

1

5

High-throughput

0.508

High

815853

STXB1
Syntaxin-binding protein 1

1

1

High-throughput

0.508

High

815864

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

8

High-throughput

0.508

High

815869

CUL3
Cullin-3

1

3

High-throughput

0.508

High

815873

ITPR3
Inositol 1,4,5-trisphosphate receptor type 3

1

1

High-throughput

0.508

High

815889

UBR4
E3 ubiquitin-protein ligase UBR4

1

2

High-throughput

0.508

High

815932

EXOC1
Exocyst complex component 1

1

1

High-throughput

0.508

High

815938

UBQL1
Ubiquilin-1

1

3

High-throughput

0.508

High

815942

AMOL2
Angiomotin-like protein 2

1

1

High-throughput

0.508

High

815947

TLN1
Talin-1

1

7

High-throughput

0.508

High

815949

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

3

High-throughput

0.508

High

175564

TM9S1
Transmembrane 9 superfamily member 1

1

4

High-throughput

0.494

High

428086

TBB5
Tubulin beta chain

1

6

High-throughput

0.494

High

683198

1433B
14-3-3 protein beta/alpha

1

8

High-throughput

0.494

High

815863

FSTL1
Follistatin-related protein 1

1

5

High-throughput

0.494

High

815900

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

13

High-throughput

0.494

High

815908

H2A1C
Histone H2A type 1-C

1

2

High-throughput

0.494

High

815911

ZDH16
Palmitoyltransferase ZDHHC16

1

4

High-throughput

0.494

High

815912

TM230
Transmembrane protein 230

1

2

High-throughput

0.494

High

815914

F241B
Protein FAM241B

1

2

High-throughput

0.494

High

815917

NP1L5
Nucleosome assembly protein 1-like 5

1

2

High-throughput

0.494

High

815926

RNF41
E3 ubiquitin-protein ligase NRDP1

1

4

High-throughput

0.494

High

815930

PYRG2
CTP synthase 2

1

1

High-throughput

0.494

High

815933

TV23B
Golgi apparatus membrane protein TVP23 homolog B

1

2

High-throughput

0.494

High

815934

CC167
Coiled-coil domain-containing protein 167

1

1

High-throughput

0.494

High

815948

TM14A
Transmembrane protein 14A

1

1

High-throughput

0.494

High

447663

ENOG
Gamma-enolase

1

0

High-throughput

0.486

High

682487

PUR9
Bifunctional purine biosynthesis protein ATIC

1

0

High-throughput

0.486

High

792173

ECE1
Endothelin-converting enzyme 1

1

0

High-throughput

0.486

High

815876

MESD
LRP chaperone MESD

1

0

High-throughput

0.486

High

815928

GBA2
Non-lysosomal glucosylceramidase

1

0

High-throughput

0.486

High

254206

SLIT1
Slit homolog 1 protein

1

1

High-throughput

0.464

High

296548

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

1

1

High-throughput

0.464

High

607020

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

1

High-throughput

0.464

High

639998

PTX3
Pentraxin-related protein PTX3

1

3

High-throughput

0.464

High

643822

SYVC
Valine--tRNA ligase

1

2

High-throughput

0.464

High

664218

TPP2
Tripeptidyl-peptidase 2

1

1

High-throughput

0.464

High

675305

SORCN
Sorcin

1

4

High-throughput

0.464

High

682721

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

3

High-throughput

0.464

High

709241

GALNS
N-acetylgalactosamine-6-sulfatase

1

2

High-throughput

0.464

High

803430

BAG6
Large proline-rich protein BAG6

1

4

High-throughput

0.464

High

815845

NASP
Nuclear autoantigenic sperm protein

1

2

High-throughput

0.464

High

815847

ASCL1
Achaete-scute homolog 1

1

1

High-throughput

0.464

High

815848

NP1L1
Nucleosome assembly protein 1-like 1

1

1

High-throughput

0.464

High

815858

1433Z
14-3-3 protein zeta/delta

1

8

High-throughput

0.464

High

815866

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

High-throughput

0.464

High

815871

UBP2L
Ubiquitin-associated protein 2-like

1

3

High-throughput

0.464

High

815874

ZN460
Zinc finger protein 460

1

1

High-throughput

0.464

High

815875

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

6

High-throughput

0.464

High

815878

IMB1
Importin subunit beta-1

1

3

High-throughput

0.464

High

815885

SVEP1
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

1

3

High-throughput

0.464

High

815886

KLH12
Kelch-like protein 12

1

3

High-throughput

0.464

High

815894

ANR12
Ankyrin repeat domain-containing protein 12

1

2

High-throughput

0.464

High

815895

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.464

High

815896

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

1

2

High-throughput

0.464

High

815897

PK1L2
Polycystin-1-like protein 2

1

5

High-throughput

0.464

High

815898

CLAP1
CLIP-associating protein 1

1

8

High-throughput

0.464

High

815903

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

5

High-throughput

0.464

High

815904

ASAP3
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

1

1

High-throughput

0.464

High

815905

COG1
Conserved oligomeric Golgi complex subunit 1

1

1

High-throughput

0.464

High

815910

HDA10
Polyamine deacetylase HDAC10

1

1

High-throughput

0.464

High

815918

IPO9
Importin-9

1

13

High-throughput

0.464

High

815920

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

4

High-throughput

0.464

High

815921

MMS19
MMS19 nucleotide excision repair protein homolog

1

1

High-throughput

0.464

High

815922

RING2
E3 ubiquitin-protein ligase RING2

1

1

High-throughput

0.464

High

815923

NP1L4
Nucleosome assembly protein 1-like 4

1

2

High-throughput

0.464

High

815931

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

4

High-throughput

0.464

High

815937

BAZ1B
Tyrosine-protein kinase BAZ1B

1

3

High-throughput

0.464

High

815943

KLH20
Kelch-like protein 20

1

3

High-throughput

0.464

High

815950

COX11
Cytochrome c oxidase assembly protein COX11, mitochondrial

1

1

High-throughput

0.464

High

73089

B4DXL2
cDNA FLJ58638, highly similar to Homo sapiens Rho GTPase activating protein 28

1

10

High-throughput

0.439

High

609001

ADRO
NADPH:adrenodoxin oxidoreductase, mitochondrial

1

2

High-throughput

0.439

High

759930

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.439

High

815843

AT5G3
ATP synthase F(0) complex subunit C3, mitochondrial

1

1

High-throughput

0.439

High

815850

KR108
Keratin-associated protein 10-8

1

2

High-throughput

0.439

High

815881

LAP4A
Lysosomal-associated transmembrane protein 4A

1

1

High-throughput

0.439

High

815919

KLHL5
Kelch-like protein 5

1

3

High-throughput

0.439

High

815940

RTRAF
RNA transcription, translation and transport factor protein

1

1

High-throughput

0.439

High

815887

Q549M8
RNA transcription, translation and transport factor protein

1

1

High-throughput

0.417

High

815888

Q59HD9
Kelch-like 5 isoform 2 variant

1

3

High-throughput

0.417

High

815891

Q6GSK2
NADPH:adrenodoxin oxidoreductase, mitochondrial

1

2

High-throughput

0.417

High

815892

Q6IBP4
Lysosomal-associated transmembrane protein 4A

1

1

High-throughput

0.417

High

815893

Q6LEU9
ATP synthase lipid-binding protein

1

1

High-throughput

0.417

High

815924

Q9BT63
60S ribosomal protein L3

1

1

High-throughput

0.417

High

815925

ZN350
Zinc finger protein 350

1

2

High-throughput

0.417

High

815935

RHG28
Rho GTPase-activating protein 28

1

10

High-throughput

0.417

High

67007

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

451863

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

2

0

Small-scale

0.313

High

70656

MYO9A
Unconventional myosin-IXa

1

0

High-throughput

0.282

High

261970

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.282

High

398835

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.282

High

815846

EMD
Emerin

1

0

High-throughput

0.282

High

815867

MAMD1
Mastermind-like domain-containing protein 1

1

0

High-throughput

0.282

High

815870

CO9A2

1

0

High-throughput

0.282

High

815884

C27C1
Cytochrome P450 27C1

1

0

High-throughput

0.282

High

815929

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

0

High-throughput

0.282

High

815941

PRLD1
PRELI domain-containing protein 1, mitochondrial

1

0

High-throughput

0.282

High

157715

GEMI2
Gem-associated protein 2

1

0

High-throughput

0.265

Low

256481

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.265

Low

297225

DDHD2
Phospholipase DDHD2

1

0

High-throughput

0.265

Low

310914

SNAPN
SNARE-associated protein Snapin

1

0

High-throughput

0.265

Low

618874

HAP40
40-kDa huntingtin-associated protein

1

0

High-throughput

0.265

Low

681169

ZEP2
Transcription factor HIVEP2

1

0

High-throughput

0.265

Low

815862

LIPS
Hormone-sensitive lipase

1

0

High-throughput

0.265

Low

815872

RBM39
RNA-binding protein 39

1

0

High-throughput

0.265

Low

815877

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.265

Low

815879

PSME4
Proteasome activator complex subunit 4

1

0

High-throughput

0.265

Low

815880

CUL7
Cullin-7

1

0

High-throughput

0.265

Low

815883

WASC4
WASH complex subunit 4

1

0

High-throughput

0.265

Low

815899

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.265

Low

815902

CMIP
C-Maf-inducing protein

1

0

High-throughput

0.265

Low

815906

P66B
Transcriptional repressor p66-beta

1

0

High-throughput

0.265

Low

815909

P2R3C
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

1

0

High-throughput

0.265

Low

815915

ABHEB
Putative protein-lysine deacylase ABHD14B

1

0

High-throughput

0.265

Low

815936

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.265

Low

815944

DDX52
Probable ATP-dependent RNA helicase DDX52

1

0

High-throughput

0.265

Low

815946

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.265

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024