HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 551
+	Hs
		1084654 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		1050209 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		1047935 KCC1A_HUMAN (15-298): 9.69e-89: 285: 26.06		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		846968 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98
+	Hs
		302331 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		SC31A_HUMAN (127-488): 4.72e-28: 121: 14.25
+	Hs
		1031324 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		516514 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		516362 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		516724 KS6B2_HUMAN (15-419): 1.39e-115: 359: 21.24		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		270386 KS6A5_HUMAN (1-314): 1.41e-86: 292: 22.05		SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98
+	Hs
		1349443 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		OGFR_HUMAN (170-417): 4.4e-09: 61.1: 21.76
+	Hs
		568649 KAPCA_HUMAN (3-316): 7.79e-90: 287: 27.41		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		516351 KAPCA_HUMAN (3-316): 7.79e-90: 287: 27.41		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Dm
		1228776 Q8MQJ7_DROME (15-221): 1.8e-26: 117: 33.18		CPSF6_DROME (8-485): 1.09e-43: 166: 36.97
+	Hs
		847056 MARK4_HUMAN (13-224): 1.59e-24: 111: 34.56		SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98