Protein: DRD3
D(3) dopamine receptor (Dopamine D3 receptor)

Gene: DRD3
Organism: Homo sapiens
Interactions: 35
UniProt ID: P35462

Gene Ontology (top 5):
GO:0001591 - dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0002031 - G protein-coupled receptor internalization
GO:0004930 - G protein-coupled receptor activity
GO:0005886 - plasma membrane
GO:0006874 - intracellular calcium ion homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

640348

DRD1
D(1A) dopamine receptor

1

18

Small-scale

0.724

High

771627

KC1D
Casein kinase I isoform delta

1

1

High-throughput

0.691

High

436622

KPCB
Protein kinase C beta type

1

2

Small-scale

0.618

High

482580

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

1

6

Small-scale

0.618

High

637372

FLNA
Filamin-A

2

5

Small-scale

0.586

High

771647

E41L1
Band 4.1-like protein 1

1

2

Small-scale

0.573

High

771636

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

2

4

Small-scale

0.566

High

771642

CLIC6
Chloride intracellular channel protein 6

1

2

Small-scale

0.527

High

771639

PDC6I
Programmed cell death 6-interacting protein

1

4

Small-scale

0.523

High

516648

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

1

High-throughput

0.514

High

771635

DSG4
Desmoglein-4

1

0

High-throughput

0.513

High

771638

LRC15
Leucine-rich repeat-containing protein 15

1

0

High-throughput

0.513

High

297294

RGS9
Regulator of G-protein signaling 9

1

2

Small-scale

0.501

High

771631

GRB2
Growth factor receptor-bound protein 2

1

10

Small-scale

0.501

High

771641

TM9S4
Transmembrane 9 superfamily member 4

1

2

High-throughput

0.489

High

771646

PTSS2
Phosphatidylserine synthase 2

1

3

High-throughput

0.489

High

771648

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

1

3

High-throughput

0.489

High

167576

GIPC1
PDZ domain-containing protein GIPC1

1

1

Small-scale

0.481

High

299745

MPDZ
Multiple PDZ domain protein

1

20

Small-scale

0.481

High

767392

RADI
Radixin

1

2

Small-scale

0.481

High

771629

COPB
Coatomer subunit beta

1

0

Small-scale

0.479

High

771628

SL9A3
Sodium/hydrogen exchanger 3

1

1

Small-scale

0.479

High

771630

NCS1
Neuronal calcium sensor 1

1

1

Small-scale

0.479

High

771632

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.479

High

771644

SH3G2
Endophilin-A1

1

19

Small-scale

0.479

High

771649

COPG1
Coatomer subunit gamma-1

1

4

Small-scale

0.457

High

771637

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

3

Small-scale

0.437

High

771643

SH3G1
Endophilin-A2

1

18

Small-scale

0.437

High

771645

SH3G3
Endophilin-A3

1

18

Small-scale

0.437

High

326669

DUS14
Dual specificity protein phosphatase 14

1

0

High-throughput

0.279

Low

595326

H15
Histone H1.5

1

0

High-throughput

0.279

Low

771633

SBP1
Methanethiol oxidase

1

0

High-throughput

0.279

Low

771640

BRI3B
BRI3-binding protein

1

0

High-throughput

0.279

Low

771626

COPD
Coatomer subunit delta

1

0

Small-scale

0.261

Low

771634

H37
Histone H3-7

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025