HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: TRI67 (Q6ZTA4)
Tripartite motif-containing protein 67 (TRIM9-like protein)
Gene: TRIM67

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36215168
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~fn3
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 783
+	Hs
		158495 IKKB_HUMAN (1-743): 0: 583: 50.87		TRI67_HUMAN (1-783): 0: 593: 100.00
+	Hs
		1170538 MARK2_HUMAN (12-724): 1.19e-142: 439: 15.92		TRI67_HUMAN (1-783): 0: 593: 100.00
+	Hs
		254493 ROCK2_HUMAN (10-739): 5.13e-122: 399: 16.40		TRI67_HUMAN (1-783): 0: 593: 100.00
+	Hs
		1172148 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		TRI67_HUMAN (1-783): 0: 593: 100.00
+	Hs
		1318683 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		TRIM9_HUMAN (1-773): 6.08e-178: 529: 61.56
+	Hs
		167580 IKKA_HUMAN (1-745): 0: 588: 100.00		TRI22_HUMAN (201-774): 3.07e-91: 296: 12.91
+	Hs
		1183133 MARK2_HUMAN (12-724): 1.19e-142: 439: 15.92		TRI36_HUMAN (115-771): 5.52e-100: 327: 20.16
+	Hs
		1190462 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		TRI46_HUMAN (1-769): 1.16e-97: 321: 20.24
+	Hs
		1019379 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		TRI26_HUMAN (194-762): 5.09e-89: 292: 12.94
+	Hs
		1050264 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		TRIM6_HUMAN (195-774): 1.16e-86: 284: 12.69
+	Hs
		158392 IKKB_HUMAN (1-743): 0: 583: 50.87		RO52_HUMAN (120-378): 1.33e-12: 72.8: 10.81
+	Hs
		167459 IKKA_HUMAN (1-745): 0: 588: 100.00		TRI27_HUMAN (105-456): 1.65e-10: 66.3: 14.77
+	Hs
		158386 IKKB_HUMAN (1-743): 0: 583: 50.87		TRI27_HUMAN (105-456): 1.65e-10: 66.3: 14.77
+	Hs
		1318703 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		TRIM7_HUMAN (203-762): 1.89e-73: 249: 15.50
+	Hs
		1049172 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		TRI14_HUMAN (301-760): 3.67e-71: 241: 17.80
+	Hs
		1050263 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		TRIM7_HUMAN (203-762): 1.89e-73: 249: 15.50
+	Hs
		585090 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		RO52_HUMAN (120-378): 1.33e-12: 72.8: 10.81
+	Mm
		1143608 TBK1_MOUSE (15-726): 8e-127: 396: 18.68		TRI27_MOUSE (105-456): 7.29e-11: 67.4: 14.77
+	Hs
		537119 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		TRI27_HUMAN (105-456): 1.65e-10: 66.3: 14.77
+	Hs
		536827 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		TRI27_HUMAN (105-456): 1.65e-10: 66.3: 14.77