Protein: ITA5
Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]

Gene: ITA5, ITGA5
Organism: Homo sapiens
Interactions: 120
UniProt ID: P08648

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001618 - virus receptor activity
GO:0001726 - ruffle
GO:0005154 - epidermal growth factor receptor binding
GO:0005161 - platelet-derived growth factor receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

431666

ITB1
Integrin beta-1

14

20

Small-scale

0.981

High

423999

ITB3
Integrin beta-3

2

20

Small-scale

0.768

High

388926

FINC
Fibronectin

8

6

Small-scale

0.753

High

127253

LEG8
Galectin-8

6

20

Small-scale

0.730

High

168363

NCTR3
Natural cytotoxicity triggering receptor 3

1

1

High-throughput

0.691

High

473708

BTNL3
Butyrophilin-like protein 3

1

11

High-throughput

0.691

High

473732

BTNL2
Butyrophilin-like protein 2

1

11

High-throughput

0.691

High

473711

ADA32
Disintegrin and metalloproteinase domain-containing protein 32

2

4

High-throughput

0.628

High

473715

TAFA4
Chemokine-like protein TAFA-4

2

4

High-throughput

0.628

High

473656

ITB5
Integrin beta-5

1

20

Small-scale

0.618

High

125162

LEG9
Galectin-9

2

20

Small-scale

0.611

High

473644

LEG1
Galectin-1

2

20

High-throughput

0.601

High

473654

LEG3
Galectin-3

2

20

High-throughput

0.601

High

473680

CD81
CD81 antigen

2

20

Small-scale

0.601

High

473733

FBX2
F-box only protein 2

2

11

High-throughput

0.601

High

178669

ANGP2
Angiopoietin-2

2

5

Small-scale

0.595

High

375105

RASK
GTPase KRas

2

20

High-throughput

0.584

High

473646

LAMP1
Lysosome-associated membrane glycoprotein 1

2

5

High-throughput

0.584

High

473719

SHRPN
Sharpin

2

7

Small-scale

0.574

High

473661

CD9
CD9 antigen

2

20

Small-scale

0.571

High

182453

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.541

High

473673

GRK6
G protein-coupled receptor kinase 6

1

4

High-throughput

0.541

High

473649

MMP9
Matrix metalloproteinase-9

1

8

Small-scale

0.536

High

473662

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

2

High-throughput

0.536

High

473677

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.536

High

473694

IL5RA
Interleukin-5 receptor subunit alpha

1

2

High-throughput

0.536

High

473696

PCDH1
Protocadherin-1

1

10

High-throughput

0.536

High

473700

RAB35
Ras-related protein Rab-35

1

7

High-throughput

0.536

High

473712

T106A
Transmembrane protein 106A

1

5

High-throughput

0.536

High

473718

TMPSD
Transmembrane protease serine 13

1

11

High-throughput

0.536

High

473720

CAD23
Cadherin-23

1

4

High-throughput

0.536

High

473725

PICK1
PRKCA-binding protein

1

4

High-throughput

0.536

High

473729

PA2GE
Group IIE secretory phospholipase A2

1

1

High-throughput

0.536

High

473735

ST14
Suppressor of tumorigenicity 14 protein

1

11

High-throughput

0.536

High

473724

FBX6
F-box only protein 6

2

11

High-throughput

0.533

High

167558

GIPC1
PDZ domain-containing protein GIPC1

1

1

Small-scale

0.527

High

340606

STABP
STAM-binding protein

1

0

High-throughput

0.518

High

473653

EGLN
Endoglin

1

1

Small-scale

0.515

High

473705

TENS2
Tensin-2

1

3

High-throughput

0.515

High

473648

CD59
CD59 glycoprotein

1

0

High-throughput

0.513

High

473689

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.513

High

473717

UBAC1
Ubiquitin-associated domain-containing protein 1

1

0

High-throughput

0.513

High

473651

TIMP2
Metalloproteinase inhibitor 2

1

1

Small-scale

0.512

High

399528

VTNC
Vitronectin

1

5

Small-scale

0.501

High

473658

VINC
Vinculin

1

4

Small-scale

0.501

High

473666

L1CAM
Neural cell adhesion molecule L1

1

1

Small-scale

0.501

High

473697

LG3BP
Galectin-3-binding protein

1

2

Small-scale

0.501

High

272604

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

3

High-throughput

0.489

High

342496

LY86
Lymphocyte antigen 86

1

2

High-throughput

0.489

High

473647

PSPC
Surfactant protein C

1

5

High-throughput

0.489

High

473665

LCN1
Lipocalin-1

1

6

High-throughput

0.489

High

473679

DEF1
Neutrophil defensin 1

1

2

High-throughput

0.489

High

473704

RN123
E3 ubiquitin-protein ligase RNF123

1

5

High-throughput

0.489

High

473706

WDR25
WD repeat-containing protein 25

1

1

High-throughput

0.489

High

473713

LEG12
Galectin-12

1

20

High-throughput

0.489

High

473736

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

5

Small-scale

0.481

High

473728

UBAP1
Ubiquitin-associated protein 1

1

0

Small-scale

0.480

High

126442

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

154552

PLPP3
Phospholipid phosphatase 3

1

1

Small-scale

0.479

High

164227

NRP1
Neuropilin-1

1

4

Small-scale

0.479

High

217740

TGON2
Trans-Golgi network integral membrane protein 2

1

9

High-throughput

0.479

High

362631

EGFR
Epidermal growth factor receptor

1

16

Small-scale

0.479

High

373738

RASN
GTPase NRas

1

20

High-throughput

0.479

High

374348

RASH
GTPase HRas

1

13

High-throughput

0.479

High

387940

FIBG
Fibrinogen gamma chain

1

5

Small-scale

0.479

High

466075

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

473645

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

Small-scale

0.479

High

473650

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

473652

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

473660

FGFR2
Fibroblast growth factor receptor 2

1

5

Small-scale

0.479

High

473663

CBL
E3 ubiquitin-protein ligase CBL

1

6

Small-scale

0.479

High

473667

TSP4
Thrombospondin-4

1

5

Small-scale

0.479

High

473668

VGFR2
Vascular endothelial growth factor receptor 2

1

6

Small-scale

0.479

High

473669

TGFR1
TGF-beta receptor type-1

1

4

Small-scale

0.479

High

473670

ACVL1
Activin receptor type-1-like

1

4

Small-scale

0.479

High

473672

VHL
von Hippel-Lindau disease tumor suppressor

1

4

Small-scale

0.479

High

473676

RAB7A
Ras-related protein Rab-7a

1

7

High-throughput

0.479

High

473678

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

473681

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

473682

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

473683

RAB2A
Ras-related protein Rab-2A

1

6

High-throughput

0.479

High

473684

CXCR4
C-X-C chemokine receptor type 4

1

2

Small-scale

0.479

High

473685

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

473686

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

473687

ARF6
ADP-ribosylation factor 6

1

7

High-throughput

0.479

High

473688

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

473690

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

473693

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

473695

CAV1
Caveolin-1

1

4

High-throughput

0.479

High

473698

ILK
Scaffold protein ILK

1

2

Small-scale

0.479

High

473699

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

4

Small-scale

0.479

High

473701

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

473702

CAH9
Carbonic anhydrase 9

1

6

High-throughput

0.479

High

473710

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

473716

CIB1
Calcium and integrin-binding protein 1

1

2

Small-scale

0.479

High

473721

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

473722

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

473726

T106B
Transmembrane protein 106B

1

5

High-throughput

0.479

High

473731

SE1L1
Protein sel-1 homolog 1

1

7

Small-scale

0.479

High

473655

IBP2
Insulin-like growth factor-binding protein 2

1

0

Small-scale

0.458

High

473664

CD40L
CD40 ligand

1

0

Small-scale

0.458

High

473692

X3CL1
Fractalkine

1

0

Small-scale

0.458

High

473675

CLK1
Dual specificity protein kinase CLK1

1

1

High-throughput

0.457

High

170632

CLGN
Calmegin

1

10

High-throughput

0.445

High

473659

VCAM1
Vascular cell adhesion protein 1

1

4

High-throughput

0.445

High

473671

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

7

Small-scale

0.445

High

473703

MICB
MHC class I polypeptide-related sequence B

1

4

High-throughput

0.445

High

473734

GAB2
GRB2-associated-binding protein 2

1

1

High-throughput

0.445

High

473674

MSS4
Guanine nucleotide exchange factor MSS4

1

3

Small-scale

0.439

High

181679

CTDSL
CTD small phosphatase-like protein

1

2

High-throughput

0.437

High

403752

GCR
Glucocorticoid receptor

1

1

High-throughput

0.437

High

473691

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.437

High

473707

VIR
Protein virilizer homolog

1

1

High-throughput

0.437

High

473709

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

473723

ST7
Suppressor of tumorigenicity 7 protein

1

2

High-throughput

0.437

High

473727

OTULL
Inactive ubiquitin thioesterase OTULINL

1

3

High-throughput

0.437

High

231436

ORC4
Origin recognition complex subunit 4

1

0

High-throughput

0.279

Low

473714

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.279

Low

473730

TXD16
Thioredoxin domain-containing protein 16

1

0

High-throughput

0.279

Low

473657

EGR1
Early growth response protein 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025