HitPredict

Interactor 1: LSM1 (O15116)
U6 snRNA-associated Sm-like protein LSm1 (Cancer-associated Sm-like) (Small nuclear ribonuclear CaSm)
Gene: LSM1

Interactor 2: LSM2 (Q9Y333)
U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5)
Gene: LSM2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.925

Property	Details
Experiments	32296183, 29395067, 15231747, 33961781, unassigned1304
Identification Methods	two hybrid, proximity labelling technology, affinity chromatography technology, two hybrid array, two hybrid prey pooling approach, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	LSM~LSM
Common GO terms	GO:0000932 - P-body GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:1990726 - Lsm1-7-Pat1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 133 Hs			1 95
+	Hs
		167728 LSM1_HUMAN (1-133): 3.57e-53: 165: 100.00		LSM4_HUMAN (1-87): 3.25e-32: 110: 32.58
+	Hs
		167682 LSM1_HUMAN (1-133): 3.57e-53: 165: 100.00		SMD1_HUMAN (1-95): 6.66e-29: 101: 28.42
+	Hs
		167678 LSM1_HUMAN (1-133): 3.57e-53: 165: 100.00		RUXF_HUMAN (3-71): 2.45e-23: 86.9: 31.43
+	Dm
		1374114 Q9W2K2_DROME (1-124): 3.53e-39: 130: 63.71		Q9VTW6_DROME (1-95): 3.77e-37: 121: 91.58
+	Hs
		321440 LSM8_HUMAN (7-95): 2.25e-31: 108: 33.33		LSM2_HUMAN (1-95): 4.21e-38: 124: 100.00
+	Dm
		1374112 Q9W087_DROME (8-97): 1.7e-31: 109: 26.37		Q9VTW6_DROME (1-95): 3.77e-37: 121: 91.58
+	Sc
		746307 LSM1_YEAST (4-123): 5.07e-34: 118: 40.98		LSM2_YEAST (1-95): 2.94e-31: 106: 63.16
+	Hs
		1356292 LSM7_HUMAN (8-89): 4.34e-27: 98.5: 29.89		LSM2_HUMAN (1-95): 4.21e-38: 124: 100.00
+	Dm
		1369698 Q9W087_DROME (8-97): 1.7e-31: 109: 26.37		Q9VKW8_DROME (1-89): 2.58e-32: 111: 34.07
+	Hs
		321444 LSM8_HUMAN (7-95): 2.25e-31: 108: 33.33		LSM4_HUMAN (1-87): 3.25e-32: 110: 32.58
+	Hs
		321389 LSM8_HUMAN (7-95): 2.25e-31: 108: 33.33		SMD1_HUMAN (1-95): 6.66e-29: 101: 28.42
+	Hs
		1356296 LSM7_HUMAN (8-89): 4.34e-27: 98.5: 29.89		LSM4_HUMAN (1-87): 3.25e-32: 110: 32.58
+	Sc
		767790 LSM1_YEAST (4-123): 5.07e-34: 118: 40.98		LSM4_YEAST (1-83): 6.73e-22: 85.7: 22.83
+	At
		1323437 Q9FI15_ARATH (4-93): 1.78e-25: 98.5: 22.00		SMD1B_ARATH (1-93): 3.01e-29: 102: 26.88
+	Hs
		912398 LSM7_HUMAN (8-89): 4.34e-27: 98.5: 29.89		SMD1_HUMAN (1-95): 6.66e-29: 101: 28.42
+	Hs
		321390 LSM8_HUMAN (7-95): 2.25e-31: 108: 33.33		SMD3_HUMAN (2-88): 6.44e-24: 89.6: 20.69
+	Dm
		1097032 Q9W087_DROME (8-97): 1.7e-31: 109: 26.37		RUXF_DROME (3-84): 2.1e-23: 86.9: 26.83
+	Hs
		321386 LSM8_HUMAN (7-95): 2.25e-31: 108: 33.33		RUXF_HUMAN (3-71): 2.45e-23: 86.9: 31.43
+	Hs
		912752 LSM7_HUMAN (8-89): 4.34e-27: 98.5: 29.89		SMD3_HUMAN (2-88): 6.44e-24: 89.6: 20.69
+	Hs
		911992 LSM7_HUMAN (8-89): 4.34e-27: 98.5: 29.89		RUXF_HUMAN (3-71): 2.45e-23: 86.9: 31.43