HitPredict

Interactor 1: LSM1 (O15116)
U6 snRNA-associated Sm-like protein LSm1 (Cancer-associated Sm-like) (Small nuclear ribonuclear CaSm)
Gene: LSM1

Interactor 2: LSM5 (Q9Y4Y9)
U6 snRNA-associated Sm-like protein LSm5
Gene: LSM5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LSM~LSM
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006397 - mRNA processing and 1 others more... GO:1990726 - Lsm1-7-Pat1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 133 Hs			1 91
+	Hs
		167677 LSM1_HUMAN (1-133): 3.57e-53: 165: 100.00		RUXE_HUMAN (1-84): 8.29e-27: 95.4: 26.37
+	Mm
		912216 LSM1_MOUSE (1-133): 1.13e-53: 166: 97.74		LSM3_MOUSE (14-85): 5.98e-23: 86.1: 26.83
+	Hs
		167680 LSM1_HUMAN (1-133): 3.57e-53: 165: 100.00		LSM3_HUMAN (14-85): 5.98e-23: 86.1: 26.83
+	Dm
		1373283 Q9W2K2_DROME (1-124): 3.53e-39: 130: 63.71		Q9VRT7_DROME (2-90): 6.85e-34: 113: 79.78
+	Hs
		167725 LSM1_HUMAN (1-133): 3.57e-53: 165: 100.00		LSM7_HUMAN (7-91): 7.4e-18: 73: 21.11
+	Hs
		321443 LSM8_HUMAN (7-95): 2.25e-31: 108: 33.33		LSM5_HUMAN (1-91): 1.1e-36: 120: 100.00
+	Hs
		167679 LSM1_HUMAN (1-133): 3.57e-53: 165: 100.00		RUXG_HUMAN (10-82): 1.17e-12: 59.2: 26.03
+	Sc
		768230 LSM1_YEAST (4-123): 5.07e-34: 118: 40.98		LSM5_YEAST (11-87): 9.08e-24: 88: 47.56
+	At
		1228013 LSM1B_ARATH (7-118): 1.52e-37: 125: 48.21		LSM7_ARATH (10-91): 2.64e-20: 79.2: 20.69
+	Hs
		321385 LSM8_HUMAN (7-95): 2.25e-31: 108: 33.33		RUXE_HUMAN (1-84): 8.29e-27: 95.4: 26.37
+	Sc
		810530 LSM1_YEAST (4-123): 5.07e-34: 118: 40.98		LSM3_YEAST (14-90): 1.46e-22: 84.6: 23.46
+	Dm
		1368680 Q9W2K2_DROME (1-124): 3.53e-39: 130: 63.71		Q9VJI7_DROME (5-91): 6.92e-17: 70.7: 17.20
+	Dm
		1213200 Q9W087_DROME (8-97): 1.7e-31: 109: 26.37		Q8IMX8_DROME (14-87): 4.98e-24: 88.8: 23.81
+	Hs
		321387 LSM8_HUMAN (7-95): 2.25e-31: 108: 33.33		LSM3_HUMAN (14-85): 5.98e-23: 86.1: 26.83
+	Mm
		912214 LSM8_MOUSE (7-95): 2.25e-31: 108: 33.33		LSM3_MOUSE (14-85): 5.98e-23: 86.1: 26.83
+	At
		1227146 LSM7_ARATH (4-88): 3.76e-28: 100: 28.89		Q8LAK5_ARATH (5-87): 3.15e-26: 93.8: 30.34
+	At
		1352284 LSM7_ARATH (4-88): 3.76e-28: 100: 28.89		Q9ZV45_ARATH (5-87): 7.89e-26: 93.1: 30.34
+	Sc
		810527 LSM1_YEAST (4-123): 5.07e-34: 118: 40.98		LSM7_YEAST (9-89): 7.29e-14: 63.4: 24.72
+	Hs
		321438 LSM8_HUMAN (7-95): 2.25e-31: 108: 33.33		LSM7_HUMAN (7-91): 7.4e-18: 73: 21.11
+	Dm
		1368679 Q9W087_DROME (8-97): 1.7e-31: 109: 26.37		Q9VJI7_DROME (5-91): 6.92e-17: 70.7: 17.20