Protein: DDR2
Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)

Gene: DDR2
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q16832

Gene Ontology (top 5):
GO:0001503 - ossification
GO:0003416 - endochondral bone growth
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
GO:0005518 - collagen binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

666123

SHC1
SHC-transforming protein 1

2

20

Small-scale

0.821

High

994642

DDR1
Epithelial discoidin domain-containing receptor 1

2

20

High-throughput

0.811

High

851514

NEK4
Serine/threonine-protein kinase Nek4

1

20

High-throughput

0.691

High

1081497

NTRK3
NT-3 growth factor receptor

1

17

High-throughput

0.691

High

523011

SRC
Proto-oncogene tyrosine-protein kinase Src

1

19

Small-scale

0.665

High

1088122

DDR2
Discoidin domain-containing receptor 2

1

19

Small-scale

0.647

High

176450

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

20

High-throughput

0.646

High

924606

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.646

High

1032971

PLD1
Phospholipase D1

1

3

High-throughput

0.646

High

1052994

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

16

High-throughput

0.646

High

1088142

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

19

High-throughput

0.646

High

384921

NTRK1
High affinity nerve growth factor receptor

1

19

High-throughput

0.618

High

793335

MUC18
Cell surface glycoprotein MUC18

1

20

High-throughput

0.618

High

972518

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

19

High-throughput

0.618

High

1088128

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1088135

HAVR1
Hepatitis A virus cellular receptor 1

1

2

Small-scale

0.618

High

438220

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.611

High

580239

CADH2
Cadherin-2

2

20

Small-scale

0.611

High

1088152

CHRD1
Cysteine and histidine-rich domain-containing protein 1

2

5

High-throughput

0.611

High

1027609

CBLB
E3 ubiquitin-protein ligase CBL-B

2

20

Small-scale

0.601

High

431907

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.594

High

1088156

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

20

High-throughput

0.578

High

500801

CLUS
Clusterin

2

5

High-throughput

0.558

High

1082788

CDC37
Hsp90 co-chaperone Cdc37

2

18

High-throughput

0.558

High

573721

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

20

High-throughput

0.553

High

1088140

OSBL8
Oxysterol-binding protein-related protein 8

1

14

High-throughput

0.553

High

952819

FOXK1
Forkhead box protein K1

2

6

High-throughput

0.543

High

534046

COBA2

1

7

Small-scale

0.536

High

364294

TFR1
Transferrin receptor protein 1

1

7

High-throughput

0.536

High

944267

PRKDC
DNA-dependent protein kinase catalytic subunit

1

10

High-throughput

0.536

High

358520

CO1A1
Collagen alpha-1(I) chain

1

7

Small-scale

0.501

High

394813

A4
Amyloid-beta precursor protein

1

12

Small-scale

0.501

High

159370

PLD2
Phospholipase D2

1

3

High-throughput

0.500

High

225635

PCDH7
Protocadherin-7

1

20

High-throughput

0.500

High

280256

CBPD
Carboxypeptidase D

1

6

High-throughput

0.500

High

319859

HERC2
E3 ubiquitin-protein ligase HERC2

1

20

High-throughput

0.500

High

363518

FETUA
Alpha-2-HS-glycoprotein

1

6

High-throughput

0.500

High

382440

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

18

High-throughput

0.500

High

506595

BCR
Breakpoint cluster region protein

1

20

High-throughput

0.500

High

657360

ABCD3
ATP-binding cassette sub-family D member 3

1

11

High-throughput

0.500

High

716698

CTNA1
Catenin alpha-1

1

11

High-throughput

0.500

High

762997

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

6

High-throughput

0.500

High

995374

LG3BP
Galectin-3-binding protein

1

12

High-throughput

0.500

High

995972

DSC1
Desmocollin-1

1

20

High-throughput

0.500

High

1028054

DNJC3
DnaJ homolog subfamily C member 3

1

20

High-throughput

0.500

High

1055828

DSC3
Desmocollin-3

1

20

High-throughput

0.500

High

1088127

ATD3B
ATPase family AAA domain-containing protein 3B

1

14

High-throughput

0.500

High

1088129

KTN1
Kinectin

1

9

High-throughput

0.500

High

1088141

MAGT1
Magnesium transporter protein 1

1

3

High-throughput

0.500

High

1088143

JPH1
Junctophilin-1

1

8

High-throughput

0.500

High

1088144

WDR6
tRNA

1

20

High-throughput

0.500

High

1088145

ATD3A
ATPase family AAA domain-containing protein 3A

1

12

High-throughput

0.500

High

1088148

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

1

High-throughput

0.500

High

1088149

HACD3
Very-long-chain

1

7

High-throughput

0.500

High

1088154

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

14

High-throughput

0.500

High

390920

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

6

High-throughput

0.489

High

901479

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

7

High-throughput

0.489

High

1088151

DJB11
DnaJ homolog subfamily B member 11

1

20

High-throughput

0.489

High

208587

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

4

High-throughput

0.479

High

310658

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

20

High-throughput

0.479

High

335121

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

6

High-throughput

0.479

High

397405

ADT2
ADP/ATP translocase 2

1

11

High-throughput

0.479

High

436329

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

505407

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

1

High-throughput

0.479

High

514014

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

3

High-throughput

0.479

High

519199

KCRB
Creatine kinase B-type

1

2

High-throughput

0.479

High

521969

CADH1
Cadherin-1

1

20

Small-scale

0.479

High

532136

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

2

High-throughput

0.479

High

560133

EPCAM
Epithelial cell adhesion molecule

1

3

High-throughput

0.479

High

571725

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

12

High-throughput

0.479

High

717128

CTNB1
Catenin beta-1

1

20

High-throughput

0.479

High

839603

SERPH
Serpin H1

1

12

High-throughput

0.479

High

845507

RAB9A
Ras-related protein Rab-9A

1

20

High-throughput

0.479

High

894740

RAB8A
Ras-related protein Rab-8A

1

16

High-throughput

0.479

High

897747

ABCE1
ATP-binding cassette sub-family E member 1

1

10

High-throughput

0.479

High

915710

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

994189

DHX9
ATP-dependent RNA helicase A

1

15

High-throughput

0.479

High

1040118

STIM1
Stromal interaction molecule 1

1

13

High-throughput

0.479

High

1078791

MSMO1
Methylsterol monooxygenase 1

1

1

High-throughput

0.479

High

1088133

DNJC9
DnaJ homolog subfamily C member 9

1

20

High-throughput

0.479

High

1088134

AP2M1
AP-2 complex subunit mu

1

14

High-throughput

0.479

High

1088138

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

2

High-throughput

0.479

High

1088150

VAPA
Vesicle-associated membrane protein-associated protein A

1

20

High-throughput

0.479

High

1088153

BAZ1B
Tyrosine-protein kinase BAZ1B

1

12

High-throughput

0.479

High

1088155

RAB21
Ras-related protein Rab-21

1

20

High-throughput

0.479

High

1088158

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.479

High

1088136

VMP1
Vacuole membrane protein 1

1

0

Small-scale

0.458

High

276913

CP7B1
Cytochrome P450 7B1

1

8

High-throughput

0.457

High

314998

SGPL1
Sphingosine-1-phosphate lyase 1

1

7

High-throughput

0.457

High

390258

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

6

High-throughput

0.457

High

596284

FILA
Filaggrin

1

11

High-throughput

0.457

High

777995

RFC3
Replication factor C subunit 3

1

3

High-throughput

0.457

High

778166

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

12

High-throughput

0.457

High

858264

TXTP
Tricarboxylate transport protein, mitochondrial

1

17

High-throughput

0.457

High

875979

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

9

High-throughput

0.457

High

964190

FOXK2
Forkhead box protein K2

1

6

High-throughput

0.457

High

1067383

OZF
Zinc finger protein OZF

1

8

High-throughput

0.457

High

1088124

MA7D1
MAP7 domain-containing protein 1

1

18

High-throughput

0.457

High

1088125

ZN260
Zinc finger protein 260

1

7

High-throughput

0.457

High

1088131

MACOI
Macoilin

1

8

High-throughput

0.457

High

1088132

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

7

High-throughput

0.457

High

1088147

TECR
Very-long-chain enoyl-CoA reductase

1

6

High-throughput

0.457

High

1041683

CUL3
Cullin-3

1

11

High-throughput

0.445

High

130513

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

7

High-throughput

0.437

High

173383

ACOX3
Peroxisomal acyl-coenzyme A oxidase 3

1

5

High-throughput

0.437

High

240591

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

5

High-throughput

0.437

High

260903

H2AY
Core histone macro-H2A.1

1

4

High-throughput

0.437

High

313545

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

20

High-throughput

0.437

High

315565

SC24A
Protein transport protein Sec24A

1

20

High-throughput

0.437

High

315710

SC24B
Protein transport protein Sec24B

1

20

High-throughput

0.437

High

438771

SRPRA
Signal recognition particle receptor subunit alpha

1

11

High-throughput

0.437

High

848857

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

11

High-throughput

0.437

High

854962

AGFG1
Arf-GAP domain and FG repeat-containing protein 1

1

20

High-throughput

0.437

High

940970

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.437

High

1073958

SC23A
Protein transport protein Sec23A

1

20

High-throughput

0.437

High

1074041

SC23B
Protein transport protein Sec23B

1

20

High-throughput

0.437

High

1088123

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

11

High-throughput

0.437

High

1088130

STX12
Syntaxin-12

1

9

High-throughput

0.437

High

1088139

RFIP5
Rab11 family-interacting protein 5

1

13

High-throughput

0.437

High

1088146

RBM28
RNA-binding protein 28

1

9

High-throughput

0.437

High

1088157

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.279

Low

608901

SPR2E
Small proline-rich protein 2E

1

0

High-throughput

0.261

Low

981265

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.261

Low

1088126

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.261

Low

1088137

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.261

Low


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Last updated: 15 Jul 2024