HitPredict

Interactor 1: FYB1 (O15117)
FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein)
Gene: FYB1

Interactor 2: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	15096483
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH3_2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 783 Hs			1 128
+	Hs
		167735 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72
+	Hs
		167737 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		FYN_HUMAN (1-125): 4.91e-37: 133: 18.52
+	Hs
		167751 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		GRB2_HUMAN (1-123): 1.97e-35: 122: 19.69
+	Mm
		193088 FYB1_MOUSE (1-783): 7.99e-67: 239: 70.52		LCK_MOUSE (1-125): 7.28e-41: 143: 19.08
+	Mm
		193089 FYB1_MOUSE (1-783): 7.99e-67: 239: 70.52		LYN_MOUSE (1-125): 1.07e-39: 140: 19.85
+	Mm
		193090 FYB1_MOUSE (1-783): 7.99e-67: 239: 70.52		FYN_MOUSE (1-125): 4.62e-37: 133: 18.52
+	Hs
		337335 MUC1_HUMAN (6-732): 3.39e-28: 124: 9.80		ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72
+	Hs
		411582 MUC1_HUMAN (6-732): 3.39e-28: 124: 9.80		LCK_HUMAN (1-125): 4.76e-41: 143: 19.08
+	Hs
		433560 MUC1_HUMAN (6-732): 3.39e-28: 124: 9.80		LYN_HUMAN (1-125): 1.04e-39: 140: 19.85
+	Hs
		522749 MUC1_HUMAN (6-732): 3.39e-28: 124: 9.80		SRC_HUMAN (1-127): 8.71e-39: 138: 20.90
+	Hs
		433853 MICA3_HUMAN (14-697): 1.07e-26: 119: 10.91		LYN_HUMAN (1-125): 1.04e-39: 140: 19.85
+	Hs
		411823 ASPP1_HUMAN (7-477): 1.69e-24: 112: 16.57		LCK_HUMAN (1-125): 4.76e-41: 143: 19.08
+	Hs
		433948 ASPP1_HUMAN (7-477): 1.69e-24: 112: 16.57		LYN_HUMAN (1-125): 1.04e-39: 140: 19.85
+	Hs
		554292 MUC1_HUMAN (6-732): 3.39e-28: 124: 9.80		GRB2_HUMAN (1-123): 1.97e-35: 122: 19.69
+	Hs
		297808 K0754_HUMAN (250-731): 8.54e-16: 84.6: 7.68		LYN_HUMAN (1-125): 1.04e-39: 140: 19.85
+	Hs
		203198 SYNJ1_HUMAN (264-675): 3.42e-09: 62.7: 8.65		LCK_HUMAN (1-125): 4.76e-41: 143: 19.08
+	Hs
		924760 PRG4_HUMAN (243-720): 1.33e-15: 83.5: 9.28		GRB2_HUMAN (1-123): 1.97e-35: 122: 19.69
+	Hs
		433954 PRAM_HUMAN (203-597): 7.84e-09: 61.1: 9.60		LYN_HUMAN (1-125): 1.04e-39: 140: 19.85
+	Hs
		517796 NFH_HUMAN (18-409): 7.32e-12: 71.5: 14.54		GRB2_HUMAN (1-123): 1.97e-35: 122: 19.69
+	Hs
		203218 SYNJ1_HUMAN (264-675): 3.42e-09: 62.7: 8.65		GRB2_HUMAN (1-123): 1.97e-35: 122: 19.69