Protein: FCGR1
High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I) (Fc-gamma RI) (FcRI) (Fc-gamma RIA) (FcgammaRIa) (CD antigen CD64)

Gene: FCGR1, FCGR1A
Organism: Homo sapiens
Interactions: 53
UniProt ID: P12314

Gene Ontology (top 5):
GO:0001788 - antibody-dependent cellular cytotoxicity
GO:0001798 - positive regulation of type IIa hypersensitivity
GO:0001805 - positive regulation of type III hypersensitivity
GO:0005886 - plasma membrane
GO:0006898 - receptor-mediated endocytosis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

553358

VSTM1
V-set and transmembrane domain-containing protein 1

2

8

High-throughput

0.783

High

553339

FCAR
Immunoglobulin alpha Fc receptor

2

16

Small-scale

0.754

High

379203

IGHG1
Immunoglobulin heavy constant gamma 1

1

6

Small-scale

0.692

High

553372

ULBP3
UL16-binding protein 3

1

11

High-throughput

0.691

High

388576

SAMP
Serum amyloid P-component

1

6

Small-scale

0.647

High

167731

PCD17
Protocadherin-17

2

3

High-throughput

0.628

High

239698

PCDH7
Protocadherin-7

2

7

High-throughput

0.628

High

553354

FREM2
FRAS1-related extracellular matrix protein 2

2

4

High-throughput

0.628

High

553375

PCD12
Protocadherin-12

2

3

High-throughput

0.628

High

139175

UPK2
Uroplakin-2

2

1

High-throughput

0.606

High

225442

ITM2A
Integral membrane protein 2A

2

4

High-throughput

0.606

High

455898

ASGR1
Asialoglycoprotein receptor 1

2

9

High-throughput

0.606

High

553348

MALL
MAL-like protein

2

1

High-throughput

0.606

High

553360

C163A
Scavenger receptor cysteine-rich type 1 protein M130

2

4

High-throughput

0.606

High

553368

NINJ1
Ninjurin-1

2

1

High-throughput

0.606

High

553371

CLC7A
C-type lectin domain family 7 member A

2

11

High-throughput

0.606

High

553344

KSYK
Tyrosine-protein kinase SYK

2

20

Small-scale

0.584

High

553355

TSPO2
Translocator protein 2

2

0

High-throughput

0.580

High

553364

CLD19
Claudin-19

2

0

High-throughput

0.580

High

553366

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

0

High-throughput

0.580

High

553377

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

2

0

High-throughput

0.580

High

553346

HBA
Hemoglobin subunit alpha

2

1

High-throughput

0.574

High

553356

MRCKA
Serine/threonine-protein kinase MRCK alpha

2

4

High-throughput

0.574

High

553378

ACAD8
Isobutyryl-CoA dehydrogenase, mitochondrial

2

1

High-throughput

0.574

High

335535

BMP10
Bone morphogenetic protein 10

2

3

High-throughput

0.553

High

553353

ADIPO
Adiponectin

2

4

High-throughput

0.553

High

553363

JAGN1
Protein jagunal homolog 1

2

2

High-throughput

0.553

High

553341

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

1

Small-scale

0.536

High

553342

TNFL9
Tumor necrosis factor ligand superfamily member 9

1

2

High-throughput

0.536

High

553347

PCDH1
Protocadherin-1

1

6

High-throughput

0.536

High

553351

SNTB2
Beta-2-syntrophin

1

5

High-throughput

0.536

High

553361

FRAS1
Extracellular matrix organizing protein FRAS1

1

13

High-throughput

0.536

High

553365

PCD20
Protocadherin-20

1

5

High-throughput

0.536

High

553374

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

1

3

High-throughput

0.536

High

553370

CLIC6
Chloride intracellular channel protein 6

1

0

High-throughput

0.518

High

217378

E41L2
Band 4.1-like protein 2

1

3

Small-scale

0.515

High

220345

LAT
Linker for activation of T-cells family member 1

1

1

Small-scale

0.479

High

473360

HCK
Tyrosine-protein kinase HCK

1

19

Small-scale

0.479

High

553352

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

1

6

Small-scale

0.479

High

553359

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

1

High-throughput

0.479

High

553345

CRKL
Crk-like protein

1

20

Small-scale

0.437

High

553357

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.407

High

553338

CBL
E3 ubiquitin-protein ligase CBL

1

2

Small-scale

0.338

High

553340

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.338

High

553349

LCP2
Lymphocyte cytosolic protein 2

1

2

Small-scale

0.338

High

553337

ITIH2
Inter-alpha-trypsin inhibitor heavy chain H2

2

0

High-throughput

0.328

High

553350

BIK
Bcl-2-interacting killer

2

0

High-throughput

0.316

High

553362

NRSN1
Neurensin-1

2

0

High-throughput

0.316

High

553367

FAM3C
Protein FAM3C

2

0

High-throughput

0.316

High

553373

TNMD
Tenomodulin

2

0

High-throughput

0.316

High

553376

RPRM
Protein reprimo

2

0

High-throughput

0.316

High

553343

STAT1
Signal transducer and activator of transcription 1-alpha/beta

2

0

Small-scale

0.305

High

553369

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025