HitPredict

Interactor 1: ARPC3 (O15145)
Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC)
Gene: ARPC3

Interactor 2: ARP3 (P61158)
Actin-related protein 3 (Actin-like protein 3)
Gene: ACTR3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.969

The method score is based on:

Property	Details
Experiments	26186194, 28514442, 33961781, 35271311, 37071682, 11741539, 24981860, 35235311, 34349018
Identification Methods	affinity chromatography technology, cross-linking study, biochemical, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Actin~P21-Arc
Common GO terms	GO:0005200 - structural constituent of cytoskeleton GO:0005634 - nucleus GO:0005829 - cytosol GO:0005885 - Arp2/3 protein complex GO:0005925 - focal adhesion and 8 others more... GO:0015629 - actin cytoskeleton GO:0016020 - membrane GO:0030027 - lamellipodium GO:0034314 - Arp2/3 complex-mediated actin nucleation GO:0035861 - site of double-strand break GO:0051015 - actin filament binding GO:0070062 - extracellular exosome GO:0070358 - actin polymerization-dependent cell motility
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	178
Hs

1	418

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024