HitPredict

Interactor 1: MDM4 (O15151)
Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)
Gene: MDM4

Interactor 2: CDN2B (P42772)
Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B)
Gene: CDKN2B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	28205554
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0008285 - negative regulation of cell population proliferation
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 138
+	Hs
		169252 MDM4_HUMAN (1-490): 0: 692: 100.00		CDN2A_HUMAN (9-137): 9.34e-55: 170: 81.96
+	Hs
		790750 MDM2_HUMAN (2-488): 0: 554: 31.56		CDN2A_HUMAN (9-137): 9.34e-55: 170: 81.96
+	Hs
		790924 MDM2_HUMAN (2-488): 0: 554: 31.56		CDN2B_HUMAN (1-138): 2.59e-45: 145: 100.00
+	Hs
		862026 MDM2_HUMAN (2-488): 0: 554: 31.56		DAPK1_HUMAN (1-99): 9.82e-20: 85.8: 20.00
+	Hs
		276169 MDM2_HUMAN (2-488): 0: 554: 31.56		PSD10_HUMAN (53-137): 1.49e-17: 77.3: 15.29
+	Hs
		257601 MDM2_HUMAN (2-488): 0: 554: 31.56		ANR17_HUMAN (3-86): 3e-13: 67.3: 24.72