HitPredict

Interactor 1: MDM4 (O15151)
Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)
Gene: MDM4

Interactor 2: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	20705607, 24127580
Identification Methods	pull down, enzymatic study, molecular sieving
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016567 - protein ubiquitination
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 147
+	Hs
		169259 MDM4_HUMAN (1-490): 0: 692: 100.00		UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12
+	Hs
		169262 MDM4_HUMAN (1-490): 0: 692: 100.00		UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28
+	Hs
		963034 MDM2_HUMAN (2-488): 0: 554: 31.56		UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20
+	Hs
		849309 MDM2_HUMAN (2-488): 0: 554: 31.56		UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12
+	Hs
		919708 MDM2_HUMAN (2-488): 0: 554: 31.56		UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00
+	Hs
		895778 MDM2_HUMAN (2-488): 0: 554: 31.56		UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28
+	Hs
		962924 MDM2_HUMAN (2-488): 0: 554: 31.56		UB2E2_HUMAN (4-146): 5.85e-75: 223: 65.73
+	Hs
		962909 MDM2_HUMAN (2-488): 0: 554: 31.56		UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43
+	Mm
		620834 MDM2_MOUSE (2-488): 0: 532: 29.78		UB2D1_MOUSE (1-147): 7.06e-83: 241: 89.12
+	Hs
		851803 MDM2_HUMAN (2-488): 0: 554: 31.56		UB2E1_HUMAN (4-146): 8.81e-73: 217: 65.73
+	Mm
		620833 MDM2_MOUSE (2-488): 0: 532: 29.78		UB2D3_MOUSE (1-147): 1.54e-81: 238: 97.28
+	Hs
		828987 MDM2_HUMAN (2-488): 0: 554: 31.56		UBE2A_HUMAN (2-144): 1.41e-70: 210: 39.16
+	Hs
		927746 MDM2_HUMAN (2-488): 0: 554: 31.56		UBE2B_HUMAN (2-144): 5.71e-70: 209: 37.76
+	Hs
		896417 MDM2_HUMAN (2-488): 0: 554: 31.56		UBE2N_HUMAN (4-147): 7.67e-69: 206: 47.22