HitPredict

Interactor 1: MDM4 (O15151)
Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)
Gene: MDM4

Interactor 2: P63 (Q9H3D4)
Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51)
Gene: TP63

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	21088494
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 680
+	Hs
		962970 MDM2_HUMAN (2-488): 0: 554: 31.56		P63_HUMAN (1-680): 0: 1143: 100.00
+	Hs
		169218 MDM4_HUMAN (1-490): 0: 692: 100.00		P73_HUMAN (40-678): 0: 909: 53.94
+	Hs
		175856 MDM2_HUMAN (2-488): 0: 554: 31.56		P73_HUMAN (40-678): 0: 909: 53.94
+	Mm
		620862 MDM2_MOUSE (2-488): 0: 532: 29.78		P73_MOUSE (54-678): 0: 890: 54.18
+	Mm
		193155 MDM4_MOUSE (1-490): 0: 678: 83.91		P53_MOUSE (139-425): 2.59e-150: 443: 48.61
+	Hs
		169227 MDM4_HUMAN (1-490): 0: 692: 100.00		P53_HUMAN (157-425): 4.82e-142: 421: 49.44
+	Mm
		356823 MDM2_MOUSE (2-488): 0: 532: 29.78		P53_MOUSE (139-425): 2.59e-150: 443: 48.61
+	Hs
		386540 MDM2_HUMAN (2-488): 0: 554: 31.56		P53_HUMAN (157-425): 4.82e-142: 421: 49.44
+	Rn
		88787 D3ZVH5_RAT (2-488): 0: 518: 28.43		P53_RAT (41-456): 1.12e-144: 428: 38.13
+	Hs
		111246 J3KN53_HUMAN (2-488): 0: 519: 28.80		P53_HUMAN (157-425): 4.82e-142: 421: 49.44