Protein: ITIH2
Inter-alpha-trypsin inhibitor heavy chain H2 (ITI heavy chain H2) (ITI-HC2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP)

Gene: ITIH2
Organism: Homo sapiens
Interactions: 92
UniProt ID: P19823

Gene Ontology (top 5):
GO:0004866 - endopeptidase inhibitor activity
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005540 - hyaluronic acid binding
GO:0005576 - extracellular region
GO:0005788 - endoplasmic reticulum lumen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

469409

ELNE
Neutrophil elastase

2

5

High-throughput

0.776

High

626000

CEA21
Cell adhesion molecule CEACAM21

3

4

High-throughput

0.770

High

132991

MATN2
Matrilin-2

1

7

High-throughput

0.691

High

210705

KLK10
Kallikrein-10

1

4

High-throughput

0.691

High

262171

KERA
Keratocan

1

5

High-throughput

0.691

High

458628

PGS2
Decorin

1

5

High-throughput

0.691

High

625983

CMA1
Chymase

1

3

High-throughput

0.691

High

625986

CEAM8
Cell adhesion molecule CEACAM8

1

4

High-throughput

0.691

High

626021

ASPN
Asporin

1

5

High-throughput

0.691

High

626031

OPT
Opticin

1

6

High-throughput

0.691

High

193062

FGF10
Fibroblast growth factor 10

3

1

High-throughput

0.667

High

529053

TAU
Microtubule-associated protein tau

3

4

Small-scale

0.624

High

625994

TSG6
Tumor necrosis factor-inducible gene 6 protein

2

2

Small-scale

0.619

High

626026

LRC4C
Leucine-rich repeat-containing protein 4C

1

2

High-throughput

0.618

High

326997

NXPH2
Neurexophilin-2

2

1

High-throughput

0.611

High

626016

PAUF
Pancreatic adenocarcinoma up-regulated factor

2

0

High-throughput

0.602

High

625984

PTX3
Pentraxin-related protein PTX3

2

1

High-throughput

0.601

High

625981

ITIH1
Inter-alpha-trypsin inhibitor heavy chain H1

1

0

High-throughput

0.586

High

377959

TNFA
Tumor necrosis factor

2

0

High-throughput

0.585

High

62095

KLRG2
Killer cell lectin-like receptor subfamily G member 2

1

0

High-throughput

0.578

High

626001

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.575

High

626018

SPSB2
SPRY domain-containing SOCS box protein 2

2

8

High-throughput

0.549

High

362751

EGFR
Epidermal growth factor receptor

2

6

High-throughput

0.543

High

139180

UPK2
Uroplakin-2

1

1

High-throughput

0.536

High

253426

CST8
Cystatin-8

1

2

High-throughput

0.536

High

282824

CRLF1
Cytokine receptor-like factor 1

1

2

High-throughput

0.536

High

416594

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

5

High-throughput

0.536

High

472380

FGF4
Fibroblast growth factor 4

1

1

High-throughput

0.536

High

480400

MMP10
Stromelysin-2

1

4

High-throughput

0.536

High

625995

DDR1
Epithelial discoidin domain-containing receptor 1

1

4

High-throughput

0.536

High

625999

PGFRL
Platelet-derived growth factor receptor-like protein

1

1

High-throughput

0.536

High

626020

ERP44
Endoplasmic reticulum resident protein 44

1

5

High-throughput

0.536

High

626022

ANGL4
Angiopoietin-related protein 4

1

4

High-throughput

0.536

High

626024

CSTL1
Cystatin-like 1

1

2

High-throughput

0.536

High

626029

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

1

High-throughput

0.536

High

626038

LIPG
Endothelial lipase

1

2

High-throughput

0.536

High

251141

B4GT4
Beta-1,4-galactosyltransferase 4

1

0

High-throughput

0.513

High

616078

LAG3
Lymphocyte activation gene 3 protein

1

0

High-throughput

0.513

High

625982

MCH
Pro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid

1

0

High-throughput

0.513

High

625997

NOGG
Noggin

1

0

High-throughput

0.513

High

626013

KRT35
Keratin, type I cuticular Ha5

1

0

High-throughput

0.513

High

626023

F234A
Protein FAM234A

1

0

High-throughput

0.513

High

626025

RISC
Retinoid-inducible serine carboxypeptidase

1

0

High-throughput

0.513

High

626030

GALP
Galanin-like peptide

1

0

High-throughput

0.513

High

626033

TKNK
Tachykinin-3

1

0

High-throughput

0.513

High

212375

SPIT2
Kunitz-type protease inhibitor 2

1

4

Small-scale

0.501

High

141778

MFNG
Beta-1,3-N-acetylglucosaminyltransferase manic fringe

1

1

High-throughput

0.489

High

169295

LECT2
Leukocyte cell-derived chemotaxin-2

1

1

High-throughput

0.489

High

194458

P2RX6
P2X purinoceptor 6

1

1

High-throughput

0.489

High

351657

SG1D1
Secretoglobin family 1D member 1

1

6

High-throughput

0.489

High

563170

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.489

High

625987

CCR1
C-C chemokine receptor type 1

1

2

High-throughput

0.489

High

625988

RYK
Tyrosine-protein kinase RYK

1

5

High-throughput

0.489

High

625990

DPP6
A-type potassium channel modulatory protein DPP6

1

1

High-throughput

0.489

High

625991

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

1

1

High-throughput

0.489

High

626002

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

2

High-throughput

0.489

High

626005

PDILT
Protein disulfide-isomerase-like protein of the testis

1

5

High-throughput

0.489

High

626008

B3GN7
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7

1

1

High-throughput

0.489

High

626009

RHBL4
Rhomboid-related protein 4

1

2

High-throughput

0.489

High

626010

LIPH
Lipase member H

1

2

High-throughput

0.489

High

626014

SPSB4
SPRY domain-containing SOCS box protein 4

1

9

High-throughput

0.489

High

626019

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

2

High-throughput

0.489

High

626034

PHF11
PHD finger protein 11

1

2

High-throughput

0.489

High

626035

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

2

High-throughput

0.489

High

387231

APOA1
Apolipoprotein A-I

1

1

High-throughput

0.479

High

389016

FINC
Fibronectin

1

7

Small-scale

0.479

High

389623

AMBP
Protein AMBP

1

4

High-throughput

0.479

High

590791

TIMP2
Metalloproteinase inhibitor 2

1

3

High-throughput

0.479

High

625993

H31
Histone H3.1

1

1

High-throughput

0.479

High

240722

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.437

High

277269

PITX3
Pituitary homeobox 3

1

2

Small-scale

0.437

High

400261

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.437

High

625998

CUL4A
Cullin-4A

1

2

High-throughput

0.437

High

626012

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

626032

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.437

High

626003

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

Small-scale

0.426

High

626006

GDPD1
Lysophospholipase D GDPD1

3

0

High-throughput

0.347

High

553337

FCGR1
High affinity immunoglobulin gamma Fc receptor I

2

0

High-throughput

0.328

High

626036

DKKL1
Dickkopf-like protein 1

2

0

High-throughput

0.328

High

625989

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.282

High

625985

NEC1
Neuroendocrine convertase 1

1

0

High-throughput

0.279

Low

626011

DCNL4
DCN1-like protein 4

1

0

High-throughput

0.279

Low

626015

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

626017

O52B2
Olfactory receptor 52B2

1

0

High-throughput

0.279

Low

626037

CD11A
Cyclin-dependent kinase 11A

1

0

High-throughput

0.279

Low

626039

HS3S4
Heparan sulfate glucosamine 3-O-sulfotransferase 4

1

0

High-throughput

0.279

Low

625992

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

625996

FOXO1
Forkhead box protein O1

1

0

High-throughput

0.249

Low

626004

UBR7
Putative E3 ubiquitin-protein ligase UBR7

1

0

High-throughput

0.249

Low

626007

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

0

Small-scale

0.249

Low

626027

ANLN
Anillin

1

0

High-throughput

0.249

Low

626028

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025