HitPredict

Interactor 1: RPAC1 (O15160)
DNA-directed RNA polymerases I and III subunit RPAC1 (DNA-directed RNA polymerase I subunit C) (RNA polymerases I and III subunit AC1) (AC40) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (RPA40) (RPA39) (RPC40)
Gene: POLR1C

Interactor 2: RPC8 (Q9Y535)
DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (RNA polymerase III subunit 22.9 kDa subunit) (RPC22.9)
Gene: POLR3H

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	33961781, 35271311, 28514442, 24981860
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003899 - DNA-directed 5'-3' RNA polymerase activity GO:0005654 - nucleoplasm GO:0005666 - RNA polymerase III complex GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 346 Hs			1 204
+	Hs
		169827 RPAC1_HUMAN (1-346): 6.24e-179: 501: 100.00		RPB7_HUMAN (1-199): 5.25e-63: 194: 17.59
+	Sc
		429676 RPAC1_YEAST (10-338): 1.98e-143: 410: 44.88		RPC8_YEAST (1-202): 1.09e-72: 220: 42.79
+	Hs
		583639 RPB3_HUMAN (45-346): 4.01e-105: 311: 26.38		RPC8_HUMAN (1-204): 1.93e-85: 252: 100.00
+	Sc
		557993 RPB3_YEAST (46-346): 5.64e-100: 299: 25.74		RPC8_YEAST (1-202): 1.09e-72: 220: 42.79
+	Hs
		583455 RPB3_HUMAN (45-346): 4.01e-105: 311: 26.38		RPB7_HUMAN (1-199): 5.25e-63: 194: 17.59
+	Sc
		557982 RPB3_YEAST (46-346): 5.64e-100: 299: 25.74		RPB7_YEAST (1-198): 1.19e-54: 173: 18.00
+	Sp
		145813 RPB3_SCHPO (50-344): 8.21e-89: 270: 24.50		RPB7_SCHPO (2-198): 2.39e-55: 175: 17.59