HitPredict

Interactor 1: RORG (P51449)
Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma)
Gene: RORC

Interactor 2: Q58EY0 (Q58EY0)
RAR related orphan receptor B isoform 1 (RAR-related orphan receptor B) (cDNA, FLJ93970, Homo sapiens RAR-related orphan receptor B (RORB), mRNA)
Gene: RORB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	23555304
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0004879 - nuclear receptor activity GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 518 Hs			1 459
+	Hs
		846421 RORG_HUMAN (1-518): 1.29e-153: 450: 100.00		RORB_HUMAN (2-459): 7.27e-137: 403: 99.78
+	Hs
		1123348 Q58EY0_HUMAN (22-509): 2.27e-123: 370: 45.10		Q58EY0_HUMAN (1-459): 1.48e-138: 407: 100.00
+	Hs
		846414 RORG_HUMAN (1-518): 1.29e-153: 450: 100.00		NR1D2_HUMAN (9-432): 6.29e-91: 289: 30.25
+	Hs
		823684 NR2C2_HUMAN (3-503): 1.71e-106: 331: 21.21		NR2C2_HUMAN (1-447): 1.02e-99: 312: 18.75
+	Hs
		592816 NR1D2_HUMAN (1-488): 1.19e-106: 331: 28.54		NR1D1_HUMAN (9-432): 1.47e-92: 294: 28.27
+	Hs
		525294 NR2C2_HUMAN (3-503): 1.71e-106: 331: 21.21		NR2C1_HUMAN (9-447): 5.38e-89: 284: 21.83
+	Dm
		709141 ECR_DROME (11-513): 8.41e-95: 308: 22.75		ECR_DROME (3-455): 3.74e-85: 281: 22.05
+	Mm
		609170 RORG_MOUSE (1-518): 1.51e-142: 422: 88.61		RARB_MOUSE (9-138): 1.6e-45: 166: 42.31
+	Mm
		579890 RORG_MOUSE (1-518): 1.51e-142: 422: 88.61		RARG_MOUSE (9-84): 2.22e-44: 162: 63.16
+	Hs
		130310 NR5A2_HUMAN (24-502): 7.37e-100: 313: 19.26		NR1I2_HUMAN (8-452): 8.17e-81: 258: 22.72
+	Hs
		592826 NR1D1_HUMAN (1-488): 1.7e-105: 329: 28.71		NR2E3_HUMAN (5-448): 1.39e-70: 231: 16.59
+	Dm
		589658 ECR_DROME (11-513): 8.41e-95: 308: 22.75		USP_DROME (4-437): 1.02e-70: 234: 18.81
+	Mm
		659676 RORG_MOUSE (1-518): 1.51e-142: 422: 88.61		RXRA_MOUSE (10-91): 4.13e-28: 117: 57.32
+	Hs
		592817 NR1D1_HUMAN (1-488): 1.7e-105: 329: 28.71		Q6NSM0_HUMAN (7-108): 8.32e-30: 122: 53.40
+	Hs
		622775 NR2C2_HUMAN (3-503): 1.71e-106: 331: 21.21		COT2_HUMAN (2-89): 1.37e-27: 115: 57.96
+	Hs
		659697 NR2C2_HUMAN (3-503): 1.71e-106: 331: 21.21		RXRB_HUMAN (10-90): 5.01e-26: 112: 55.56
+	Dm
		558425 ECR_DROME (11-513): 8.41e-95: 308: 22.75		7UP1_DROME (8-89): 4.02e-27: 115: 59.76