Protein: KAPCB
cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11)

Gene: KAPCB, PRKACB
Organism: Homo sapiens
Interactions: 185
UniProt ID: P22694

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001843 - neural tube closure
GO:0003091 - renal water homeostasis
GO:0004674 - protein serine/threonine kinase activity
GO:0004691 - cAMP-dependent protein kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

605552

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

11

14

Small-scale

0.977

High

530997

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

11

20

Small-scale

0.976

High

651618

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

9

20

High-throughput

0.973

High

651657

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

6

18

High-throughput

0.953

High

568758

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

6

20

High-throughput

0.950

High

651617

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

6

20

High-throughput

0.949

High

468076

HS90B
Heat shock protein HSP 90-beta

4

20

High-throughput

0.886

High

651739

IPKG
cAMP-dependent protein kinase inhibitor gamma

3

2

High-throughput

0.871

High

651656

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

3

19

High-throughput

0.855

High

650520

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

2

14

High-throughput

0.811

High

461153

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.789

High

651636

IPKA
cAMP-dependent protein kinase inhibitor alpha

2

2

High-throughput

0.783

High

651687

GP161
G-protein coupled receptor 161

3

4

High-throughput

0.779

High

240763

PRKN
E3 ubiquitin-protein ligase parkin

2

11

High-throughput

0.754

High

440369

FYN
Tyrosine-protein kinase Fyn

2

17

High-throughput

0.737

High

651625

KPCI
Protein kinase C iota type

2

18

High-throughput

0.737

High

651649

KPCZ
Protein kinase C zeta type

2

18

High-throughput

0.737

High

651670

MYOME
Myomegalin

6

18

Small-scale

0.736

High

651712

AKAP9
A-kinase anchor protein 9

6

16

High-throughput

0.735

High

651733

AKA11
A-kinase anchor protein 11

6

2

High-throughput

0.735

High

651613

AKAP5
A-kinase anchor protein 5

5

4

High-throughput

0.725

High

651691

AKAP1
A-kinase anchor protein 1, mitochondrial

5

5

High-throughput

0.725

High

651729

VAPA
Vesicle-associated membrane protein-associated protein A

5

4

High-throughput

0.722

High

651730

AKA7G
A-kinase anchor protein 7 isoform gamma

5

4

High-throughput

0.722

High

651708

CK5P2
CDK5 regulatory subunit-associated protein 2

5

20

High-throughput

0.716

High

651666

H90B4
Putative heat shock protein HSP 90-beta 4

2

20

High-throughput

0.712

High

651644

CSK21
Casein kinase II subunit alpha

1

16

High-throughput

0.710

High

332871

VAPB
Vesicle-associated membrane protein-associated protein B/C

4

4

High-throughput

0.699

High

651622

ACV1B
Activin receptor type-1B

1

2

High-throughput

0.698

High

651642

DYL1
Dynein light chain 1, cytoplasmic

4

5

High-throughput

0.697

High

244224

NUAK1
NUAK family SNF1-like kinase 1

1

15

High-throughput

0.691

High

651629

GSK3A
Glycogen synthase kinase-3 alpha

1

19

High-throughput

0.691

High

651652

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

11

High-throughput

0.691

High

651673

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

3

High-throughput

0.691

High

651704

ZN641
Zinc finger protein 641

1

1

High-throughput

0.691

High

651716

DUS16
Dual specificity protein phosphatase 16

1

2

High-throughput

0.691

High

651635

MLF1
Myeloid leukemia factor 1

3

2

High-throughput

0.667

High

651663

MARE1
Microtubule-associated protein RP/EB family member 1

3

2

High-throughput

0.667

High

651679

AKA28
A-kinase anchor protein 14

3

2

High-throughput

0.667

High

651699

AP2M1
AP-2 complex subunit mu

3

3

High-throughput

0.667

High

651711

SNAG
Gamma-soluble NSF attachment protein

3

1

High-throughput

0.667

High

651692

RYR2
Ryanodine receptor 2

1

12

Small-scale

0.647

High

595938

H12
Histone H1.2

3

2

Small-scale

0.640

High

651632

PGTB2
Geranylgeranyl transferase type-2 subunit beta

3

0

High-throughput

0.638

High

651647

RT15
Small ribosomal subunit protein uS15m

2

1

High-throughput

0.628

High

651689

RPGF5
Rap guanine nucleotide exchange factor 5

2

7

High-throughput

0.628

High

651710

NPAS1
Neuronal PAS domain-containing protein 1

2

5

High-throughput

0.628

High

411357

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.618

High

573328

ENPL
Endoplasmin

1

20

High-throughput

0.618

High

580876

RAC2
Ras-related C3 botulinum toxin substrate 2

1

7

High-throughput

0.618

High

651148

CBL
E3 ubiquitin-protein ligase CBL

1

4

High-throughput

0.618

High

651621

FUS
RNA-binding protein FUS

1

11

Small-scale

0.618

High

651630

GSK3B
Glycogen synthase kinase-3 beta

1

19

High-throughput

0.618

High

651634

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

19

High-throughput

0.618

High

651641

RAN
GTP-binding nuclear protein Ran

1

2

Small-scale

0.618

High

651654

TADBP
TAR DNA-binding protein 43

1

13

Small-scale

0.618

High

651662

NONO
Non-POU domain-containing octamer-binding protein

1

14

Small-scale

0.618

High

651706

CCNL2
Cyclin-L2

1

3

High-throughput

0.618

High

651718

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.618

High

303034

DFFB
DNA fragmentation factor subunit beta

2

0

High-throughput

0.602

High

651631

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

2

0

High-throughput

0.602

High

651707

DCR1C
Protein artemis

2

0

High-throughput

0.585

High

315121

RECQ4
ATP-dependent DNA helicase Q4

2

12

Small-scale

0.584

High

385460

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

15

Small-scale

0.584

High

651676

H32
Histone H3.2

2

7

Small-scale

0.584

High

254808

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.575

High

651664

PKN2
Serine/threonine-protein kinase N2

1

17

High-throughput

0.575

High

651667

HS904
Putative heat shock protein HSP 90-alpha A4

1

20

High-throughput

0.575

High

651680

NOXA1
NADPH oxidase activator 1

1

2

Small-scale

0.575

High

651721

PKHA5
Pleckstrin homology domain-containing family A member 5

1

11

High-throughput

0.575

High

562696

BMP1
Bone morphogenetic protein 1

2

2

High-throughput

0.574

High

651725

KLH28
Kelch-like protein 28

2

4

High-throughput

0.574

High

186698

P73
Tumor protein p73

1

2

Small-scale

0.573

High

466562

TNR16
Tumor necrosis factor receptor superfamily member 16

1

4

Small-scale

0.573

High

651690

APBP2
Amyloid protein-binding protein 2

1

2

High-throughput

0.573

High

193208

SOCS1
Suppressor of cytokine signaling 1

2

11

High-throughput

0.571

High

651674

RHG36
Rho GTPase-activating protein 36

2

3

High-throughput

0.571

High

651696

BAD
Bcl2-associated agonist of cell death

2

5

High-throughput

0.571

High

651740

PLAK2
PALM2-AKAP2 fusion protein

2

1

High-throughput

0.558

High

651669

AVPI1
Arginine vasopressin-induced protein 1

2

1

High-throughput

0.553

High

651675

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.553

High

651639

RS6
Small ribosomal subunit protein eS6

1

6

High-throughput

0.541

High

651686

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

3

High-throughput

0.541

High

186319

RA51B
DNA repair protein RAD51 homolog 2

1

2

High-throughput

0.536

High

437569

MYL1
Myosin light chain 1/3, skeletal muscle isoform

1

2

High-throughput

0.536

High

536315

MTAP2
Microtubule-associated protein 2

1

14

High-throughput

0.536

High

556840

MYH1
Myosin-1

1

10

High-throughput

0.536

High

562995

MYH6
Myosin-6

1

10

High-throughput

0.536

High

651616

COR1A
Coronin-1A

1

5

High-throughput

0.536

High

651620

TIMP3
Metalloproteinase inhibitor 3

1

1

High-throughput

0.536

High

651637

DCAF7
DDB1- and CUL4-associated factor 7

1

5

High-throughput

0.536

High

651671

CR3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3

1

6

High-throughput

0.536

High

651681

CEP57
Centrosomal protein of 57 kDa

1

1

High-throughput

0.536

High

651694

FGF14
Fibroblast growth factor 14

1

3

High-throughput

0.536

High

651701

DYL2
Dynein light chain 2, cytoplasmic

1

5

High-throughput

0.536

High

651713

SMAKA
Small membrane A-kinase anchor protein

1

1

High-throughput

0.536

High

651722

PICK1
PRKCA-binding protein

1

3

High-throughput

0.536

High

651734

MYH2
Myosin-2

1

10

High-throughput

0.536

High

651743

MYH4
Myosin-4

1

10

High-throughput

0.536

High

651745

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

1

High-throughput

0.536

High

651627

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.518

High

651697

H2B1H
Histone H2B type 1-H

1

16

High-throughput

0.515

High

421509

A4
Amyloid-beta precursor protein

1

8

High-throughput

0.515

High

341897

CEP43
Centrosomal protein 43

1

0

High-throughput

0.513

High

651665

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.513

High

651684

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.513

High

651700

DDX11
ATP-dependent DNA helicase DDX11

1

0

High-throughput

0.513

High

651714

NAA11
N-alpha-acetyltransferase 11

1

0

High-throughput

0.513

High

651726

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.513

High

651731

MAP10
Microtubule-associated protein 10

1

0

High-throughput

0.513

High

651695

GPKOW
G-patch domain and KOW motifs-containing protein

1

2

Small-scale

0.506

High

481431

STP1
Spermatid nuclear transition protein 1

1

2

Small-scale

0.501

High

651741

FBX7
F-box only protein 7

1

3

High-throughput

0.501

High

172474

XPO1
Exportin-1

1

8

High-throughput

0.479

High

193748

PER1
Period circadian protein homolog 1

1

5

High-throughput

0.479

High

228963

AKAP8
A-kinase anchor protein 8

1

3

Small-scale

0.479

High

366153

HPT
Haptoglobin

1

2

High-throughput

0.479

High

387948

FIBG
Fibrinogen gamma chain

1

2

High-throughput

0.479

High

390863

TRFE
Serotransferrin

1

4

High-throughput

0.479

High

418834

H2A1B
Histone H2A type 1-B/E

1

3

Small-scale

0.479

High

557866

XRCC6
X-ray repair cross-complementing protein 6

1

2

Small-scale

0.479

High

559221

XRCC5
X-ray repair cross-complementing protein 5

1

2

Small-scale

0.479

High

608451

DDX5
Probable ATP-dependent RNA helicase DDX5

1

8

Small-scale

0.479

High

621554

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

Small-scale

0.479

High

651614

1433T
14-3-3 protein theta

1

19

High-throughput

0.479

High

651615

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

4

Small-scale

0.479

High

651619

H2B1B
Histone H2B type 1-B

1

16

Small-scale

0.479

High

651626

MATR3
Matrin-3

1

4

Small-scale

0.479

High

651628

RBP2
E3 SUMO-protein ligase RanBP2

1

3

Small-scale

0.479

High

651638

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

10

Small-scale

0.479

High

651640

H4
Histone H4

1

1

Small-scale

0.479

High

651643

YBOX1
Y-box-binding protein 1

1

3

Small-scale

0.479

High

651645

H31
Histone H3.1

1

7

Small-scale

0.479

High

651646

PRKDC
DNA-dependent protein kinase catalytic subunit

1

17

Small-scale

0.479

High

651648

H33
Histone H3.3

1

7

Small-scale

0.479

High

651651

DHX9
ATP-dependent RNA helicase A

1

1

Small-scale

0.479

High

651653

TRAF3
TNF receptor-associated factor 3

1

7

Small-scale

0.479

High

651655

TIF1B
Transcription intermediary factor 1-beta

1

6

Small-scale

0.479

High

651661

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

Small-scale

0.479

High

651672

H2A2A
Histone H2A type 2-A

1

3

Small-scale

0.479

High

651677

H2AV
Histone H2A.V

1

4

Small-scale

0.479

High

651678

MAVS
Mitochondrial antiviral-signaling protein

1

4

Small-scale

0.479

High

651685

NIN
Ninein

1

15

High-throughput

0.479

High

651693

DDX17
Probable ATP-dependent RNA helicase DDX17

1

8

Small-scale

0.479

High

651698

H2B1A
Histone H2B type 1-A

1

16

Small-scale

0.479

High

651705

H2A1A
Histone H2A type 1-A

1

3

Small-scale

0.479

High

651709

PITX2
Pituitary homeobox 2

1

5

High-throughput

0.479

High

651715

DDX23
Probable ATP-dependent RNA helicase DDX23

1

9

Small-scale

0.479

High

651717

ATG5
Autophagy protein 5

1

2

High-throughput

0.479

High

651723

RN216
E3 ubiquitin-protein ligase RNF216

1

2

Small-scale

0.479

High

651727

DDX56
Probable ATP-dependent RNA helicase DDX56

1

13

Small-scale

0.479

High

651728

NOP53
Ribosome biogenesis protein NOP53

1

2

Small-scale

0.479

High

651736

AKP8L
A-kinase anchor protein 8-like

1

3

Small-scale

0.479

High

651742

TRAF6
TNF receptor-associated factor 6

1

8

Small-scale

0.479

High

651744

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

1

13

Small-scale

0.479

High

522239

OSTP
Osteopontin

1

0

Small-scale

0.460

High

293203

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

541829

TOP1
DNA topoisomerase 1

1

0

Small-scale

0.458

High

651623

TALDO
Transaldolase

1

0

High-throughput

0.458

High

651659

PEBB
Core-binding factor subunit beta

1

0

High-throughput

0.458

High

651660

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.458

High

651720

NHEJ1
Non-homologous end-joining factor 1

1

0

Small-scale

0.458

High

651732

TFP11
Tuftelin-interacting protein 11

1

0

Small-scale

0.458

High

651650

STP2
Nuclear transition protein 2

1

2

Small-scale

0.457

High

224409

AKA7A
A-kinase anchor protein 7 isoforms alpha and beta

1

4

High-throughput

0.445

High

529085

TAU
Microtubule-associated protein tau

1

15

High-throughput

0.445

High

578635

GLNA
Glutamine synthetase

1

1

High-throughput

0.445

High

635293

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

1

High-throughput

0.445

High

637346

FLNA
Filamin-A

1

2

Small-scale

0.445

High

651658

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

651703

CEP63
Centrosomal protein of 63 kDa

1

12

High-throughput

0.445

High

651724

TRM1
tRNA

1

1

High-throughput

0.445

High

651737

TRI33
E3 ubiquitin-protein ligase TRIM33

1

4

High-throughput

0.445

High

651738

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

391183

FRIL
Ferritin light chain

1

0

High-throughput

0.426

High

651633

RCAN1
Calcipressin-1

1

0

Small-scale

0.426

High

651682

NNRD
ATP-dependent

1

0

High-throughput

0.426

High

651668

ARMX4
Armadillo repeat-containing X-linked protein 4

1

1

High-throughput

0.407

High

651683

MA7D3
MAP7 domain-containing protein 3

1

1

High-throughput

0.407

High

651688

PNMA1
Paraneoplastic antigen Ma1

1

2

High-throughput

0.407

High

651702

C170L
Cep170-like protein

1

2

High-throughput

0.407

High

651735

PNMA2
Paraneoplastic antigen Ma2

1

2

High-throughput

0.407

High

651624

ETFB
Electron transfer flavoprotein subunit beta

2

0

High-throughput

0.328

High

651719

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

1

0

High-throughput

0.249

Low

134239

RPOM
DNA-directed RNA polymerase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025