HitPredict

Interactor 1: TIF1A (O15164)
Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24)
Gene: TRIM24

Interactor 2: TIF1B (Q13263)
Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)
Gene: TRIM28

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.951

The method score is based on:

Property Details
Experiments 30479348, 34518220, 12684500, 29955894, 35271311, 21531907
Identification Methods affinity chromatography technology, pull down, fluorescent resonance energy transfer, anti bait coimmunoprecipitation, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Bromodomain~PHD, PHD~PHD, zf-B_box~zf-B_box
Common GO terms GO:0000791 - euchromatin
GO:0003682 - chromatin binding
GO:0003713 - transcription coactivator activity
GO:0004672 - protein kinase activity
GO:0005634 - nucleus
and 4 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

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Hs

1 835
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024