HitPredict

Interactor 1: AXIN1 (O15169)
Axin-1 (Axis inhibition protein 1) (hAxin)
Gene: AXIN1

Interactor 2: KC1E (P49674)
Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1)
Gene: CSNK1E

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.884

Property	Details
Experiments	11884395, 26496610, 21988832, 22682247
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Pkinase~RGS
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0060070 - canonical Wnt signaling pathway
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 862 Hs			1 416
+	Hs
		170616 AXIN1_HUMAN (1-862): 0: 1135: 100.00		KC1A_HUMAN (2-326): 1.03e-134: 391: 69.54
+	Hs
		170617 AXIN1_HUMAN (1-862): 0: 1135: 100.00		KC1D_HUMAN (1-406): 2e-125: 370: 83.25
+	Mm
		659448 RGS14_MOUSE (45-330): 3.14e-65: 230: 22.76		KCC2B_MOUSE (4-396): 1.78e-120: 362: 16.91
+	Mm
		956620 RGS14_MOUSE (45-330): 3.14e-65: 230: 22.76		KCC2D_MOUSE (4-339): 1.58e-119: 358: 16.62
+	Mm
		956590 RGS14_MOUSE (45-330): 3.14e-65: 230: 22.76		MARK2_MOUSE (2-416): 2.98e-115: 356: 19.63
+	Mm
		956670 RGS14_MOUSE (45-330): 3.14e-65: 230: 22.76		KCC2G_MOUSE (4-382): 2.72e-118: 356: 15.80
+	Dm
		870292 AXN_DROME (19-222): 6.58e-33: 138: 27.18		KC1A_DROME (2-321): 9.31e-123: 361: 64.38