Protein: HEXB
Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A]

Gene: HEXB
Organism: Homo sapiens
Interactions: 68
UniProt ID: P07686

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0001669 - acrosomal vesicle
GO:0004563 - beta-N-acetylhexosaminidase activity
GO:0005576 - extracellular region
GO:0005764 - lysosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

449555

HEXA
Beta-hexosaminidase subunit alpha

3

1

Small-scale

0.866

High

361063

SODC
Superoxide dismutase [Cu-Zn]

2

0

High-throughput

0.602

High

458943

FBX2
F-box only protein 2

2

2

High-throughput

0.601

High

458902

HXA1
Homeobox protein Hox-A1

2

0

High-throughput

0.580

High

458930

F210B
Protein FAM210B, mitochondrial

2

0

High-throughput

0.580

High

458895

HEXB
Beta-hexosaminidase subunit beta

1

1

Small-scale

0.575

High

458898

MPRI
Cation-independent mannose-6-phosphate receptor

1

1

High-throughput

0.536

High

458900

CALX
Calnexin

1

2

High-throughput

0.536

High

231083

AIRE
Autoimmune regulator

1

0

High-throughput

0.518

High

423726

APOD
Apolipoprotein D

1

0

High-throughput

0.513

High

458897

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.513

High

458907

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

0

High-throughput

0.513

High

458933

TSNAX
Translin-associated protein X

1

0

High-throughput

0.513

High

131672

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.493

High

327678

UBL3
Ubiquitin-like protein 3

1

0

High-throughput

0.493

High

458929

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.493

High

458904

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.486

High

142789

NFIB
Nuclear factor 1 B-type

1

1

High-throughput

0.479

High

362609

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

458896

NFIC
Nuclear factor 1 C-type

1

1

High-throughput

0.479

High

458913

CUL3
Cullin-3

1

1

High-throughput

0.479

High

458937

FBX6
F-box only protein 6

1

2

High-throughput

0.479

High

458940

T106B
Transmembrane protein 106B

1

1

High-throughput

0.479

High

294770

CAN15
Calpain-15

1

1

High-throughput

0.470

High

458920

UBQLN
Ubiquilin-like protein

1

3

High-throughput

0.470

High

458935

UBQL3
Ubiquilin-3

1

3

High-throughput

0.470

High

458942

UBQL2
Ubiquilin-2

1

3

High-throughput

0.470

High

458901

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.458

High

458903

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

458911

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

458919

TM192
Transmembrane protein 192

1

0

High-throughput

0.458

High

458923

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

458926

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

458938

TMPS4
Transmembrane protease serine 4

1

0

High-throughput

0.458

High

170623

CLGN
Calmegin

1

2

High-throughput

0.445

High

116407

POTB2
POTE ankyrin domain family member B2

1

2

High-throughput

0.437

High

217726

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

458916

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

458941

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

2053

POTEB
POTE ankyrin domain family member B

1

2

High-throughput

0.407

High

49149

POTB3
POTE ankyrin domain family member B3

1

2

High-throughput

0.407

High

458939

TM14B
Transmembrane protein 14B

2

0

High-throughput

0.316

High

458905

CSK21
Casein kinase II subunit alpha

1

0

High-throughput

0.279

Low

458932

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.279

Low

297407

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

High-throughput

0.268

Low

458906

XIAP
E3 ubiquitin-protein ligase XIAP

1

0

High-throughput

0.268

Low

458908

TLE1
Transducin-like enhancer protein 1

1

0

High-throughput

0.268

Low

458909

ZBT16
Zinc finger and BTB domain-containing protein 16

1

0

High-throughput

0.268

Low

458910

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

0

High-throughput

0.268

Low

458912

ULA1
NEDD8-activating enzyme E1 regulatory subunit

1

0

High-throughput

0.268

Low

458915

RWDD4
RWD domain-containing protein 4

1

0

High-throughput

0.268

Low

458917

Q7KZS0
SUMO-conjugating enzyme UBC9

1

0

High-throughput

0.268

Low

458918

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.268

Low

458921

KLH36
Kelch-like protein 36

1

0

High-throughput

0.268

Low

458924

NUP43
Nucleoporin Nup43

1

0

High-throughput

0.268

Low

458925

LNX1
E3 ubiquitin-protein ligase LNX

1

0

High-throughput

0.268

Low

458928

RN183
E3 ubiquitin-protein ligase RNF183

1

0

High-throughput

0.268

Low

458931

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.268

Low

458934

NXF2
Nuclear RNA export factor 2

1

0

High-throughput

0.268

Low

458944

CSN3
COP9 signalosome complex subunit 3

1

0

High-throughput

0.268

Low

458945

ASB3
Ankyrin repeat and SOCS box protein 3

1

0

High-throughput

0.268

Low

458914

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.249

Low

458936

MT21D
Protein N-lysine methyltransferase METTL21D

1

0

High-throughput

0.249

Low

213042

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.232

Low

458899

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

458922

POC5
Centrosomal protein POC5

1

0

High-throughput

0.232

Low

458927

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025