HitPredict

Interactor 1: RGL2 (O15211)
Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L)
Gene: RGL2

Interactor 2: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	21988832
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	RA~Ras, Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 777 Hs			1 189
+	Hs
		171532 RGL2_HUMAN (11-777): 0: 804: 100.00		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		171531 RGL2_HUMAN (11-777): 0: 804: 100.00		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Mm
		440302 RGL2_MOUSE (11-777): 0: 800: 89.58		RASN_MOUSE (1-189): 3.34e-86: 253: 85.71
+	Mm
		699619 RGL2_MOUSE (11-777): 0: 800: 89.58		RASK_MOUSE (1-189): 4.5e-77: 230: 98.94
+	Hs
		171541 RGL2_HUMAN (11-777): 0: 804: 100.00		RAP1B_HUMAN (1-165): 1.02e-62: 193: 57.49
+	Hs
		171535 RGL2_HUMAN (11-777): 0: 804: 100.00		RALA_HUMAN (4-169): 5.37e-58: 182: 53.29
+	Hs
		349692 RGL1_HUMAN (49-760): 0: 581: 32.27		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		348971 RGL1_HUMAN (49-760): 0: 581: 32.27		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Mm
		1113379 RGL3_MOUSE (43-745): 0: 553: 34.53		RASH_MOUSE (1-188): 6.53e-87: 255: 86.77
+	Hs
		349360 RGL3_HUMAN (43-745): 9.01e-177: 526: 35.11		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		348697 RGL3_HUMAN (43-745): 9.01e-177: 526: 35.11		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		919681 RGL1_HUMAN (49-760): 0: 581: 32.27		RAP1A_HUMAN (1-165): 7.83e-63: 194: 58.08
+	Hs
		897964 RGL1_HUMAN (49-760): 0: 581: 32.27		RAP1B_HUMAN (1-165): 1.02e-62: 193: 57.49
+	Hs
		349455 GRP3_HUMAN (93-768): 3.48e-171: 511: 18.91		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		1273185 RGL1_HUMAN (49-760): 0: 581: 32.27		RIT1_HUMAN (3-176): 8.94e-56: 177: 50.29
+	Dm
		442998 Q86BI2_DROME (45-739): 3.76e-162: 490: 28.18		RAS1_DROME (1-165): 9.63e-88: 257: 85.46
+	Mm
		936775 RGL3_MOUSE (43-745): 0: 553: 34.53		RIT1_MOUSE (3-176): 4.5e-56: 177: 50.29
+	Mm
		1113380 RGL3_MOUSE (43-745): 0: 553: 34.53		RALB_MOUSE (4-179): 1.46e-54: 173: 51.69
+	Hs
		1109718 RGL3_HUMAN (43-745): 9.01e-177: 526: 35.11		RIT1_HUMAN (3-176): 8.94e-56: 177: 50.29
+	Dm
		442959 Q86BI2_DROME (45-739): 3.76e-162: 490: 28.18		RAP1_DROME (1-163): 3.2e-63: 194: 58.54