HitPredict

Interactor 1: WDR46 (O15213)
WD repeat-containing protein 46 (WD repeat-containing protein BING4)
Gene: WDR46

Interactor 2: BRX1 (Q8TDN6)
Ribosome biogenesis protein BRX1 homolog (Brix domain-containing protein 2)
Gene: BRIX1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005730 - nucleolus
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 610 Hs			1 353
+	Hs
		69602 B0UZZ8_HUMAN (1-610): 1.27e-169: 498: 99.84		BRX1_HUMAN (1-353): 6.13e-146: 418: 100.00
+	Hs
		171816 WDR46_HUMAN (1-610): 9.77e-170: 498: 100.00		IMP4_HUMAN (2-272): 6.92e-91: 275: 17.56
+	Hs
		69606 B0UZZ8_HUMAN (1-610): 1.27e-169: 498: 99.84		IMP4_HUMAN (2-272): 6.92e-91: 275: 17.56
+	Hs
		171844 WDR46_HUMAN (1-610): 9.77e-170: 498: 100.00		SSF1_HUMAN (54-228): 2.87e-21: 96.4: 15.22
+	Hs
		69624 B0UZZ8_HUMAN (1-610): 1.27e-169: 498: 99.84		SSF1_HUMAN (54-228): 2.87e-21: 96.4: 15.22
+	Sc
		767434 UTP7_YEAST (91-608): 2.22e-88: 286: 36.98		BRX1_YEAST (40-305): 1.92e-92: 279: 45.32
+	Sc
		767398 UTP7_YEAST (91-608): 2.22e-88: 286: 36.98		IMP4_YEAST (4-278): 4.96e-80: 248: 18.51
+	Hs
		1255224 NLE1_HUMAN (43-222): 1.83e-14: 78.2: 12.78		BRX1_HUMAN (1-353): 6.13e-146: 418: 100.00
+	Sc
		630859 NLE1_YEAST (313-489): 9.2e-42: 159: 12.90		SSF1_YEAST (39-230): 7.36e-18: 86.4: 14.88
+	Sc
		630856 NLE1_YEAST (313-489): 9.2e-42: 159: 12.90		RPF2_YEAST (71-267): 1.62e-13: 72.5: 19.56
+	Hs
		1332921 NLE1_HUMAN (43-222): 1.83e-14: 78.2: 12.78		RPF2_HUMAN (106-247): 1.01e-31: 122: 22.88