Protein: KLC4
Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8)

Gene: KLC4
Organism: Homo sapiens
Interactions: 121
UniProt ID: Q9NSK0

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005871 - kinesin complex
GO:0005874 - microtubule
GO:0007018 - microtubule-based movement
GO:0019894 - kinesin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1060578

KLC1
Kinesin light chain 1

5

16

High-throughput

0.930

High

1429710

KLC2
Kinesin light chain 2

4

17

High-throughput

0.897

High

1242701

KLC3
Kinesin light chain 3

2

18

High-throughput

0.811

High

730283

1433B
14-3-3 protein beta/alpha

7

20

High-throughput

0.747

High

990784

1433Z
14-3-3 protein zeta/delta

6

20

High-throughput

0.736

High

691473

1433T
14-3-3 protein theta

6

20

High-throughput

0.733

High

966927

1433G
14-3-3 protein gamma

5

20

High-throughput

0.720

High

1049828

1433F
14-3-3 protein eta

5

20

High-throughput

0.716

High

972050

1433E
14-3-3 protein epsilon

4

8

High-throughput

0.701

High

1279983

NECA2
N-terminal EF-hand calcium-binding protein 2

3

1

High-throughput

0.675

High

1415931

KATL1
Katanin p60 ATPase-containing subunit A-like 1

3

12

High-throughput

0.675

High

171811

AZIN1
Antizyme inhibitor 1

3

2

High-throughput

0.667

High

244874

TRAK2
Trafficking kinesin-binding protein 2

3

20

High-throughput

0.667

High

1151665

TRIP6
Thyroid receptor-interacting protein 6

3

3

High-throughput

0.667

High

1323892

SYNE4
Nesprin-4

4

7

High-throughput

0.644

High

1146184

K1H1
Keratin, type I cuticular Ha1

4

17

High-throughput

0.643

High

1338990

NUP43
Nucleoporin Nup43

4

9

High-throughput

0.630

High

750011

KINH
Kinesin-1 heavy chain

2

20

High-throughput

0.628

High

1326644

KIF2B
Kinesin-like protein KIF2B

2

11

High-throughput

0.628

High

1115092

CUL4A
Cullin-4A

1

7

High-throughput

0.618

High

1449430

ACHA9
Neuronal acetylcholine receptor subunit alpha-9

3

2

High-throughput

0.609

High

1449439

KPTN
KICSTOR complex protein kaptin

3

2

High-throughput

0.609

High

1294185

CEP57
Centrosomal protein of 57 kDa

2

3

High-throughput

0.606

High

423284

A4
Amyloid-beta precursor protein

2

3

High-throughput

0.602

High

1449431

SRTD1
SERTA domain-containing protein 1

2

0

High-throughput

0.580

High

108095

G3V5R9
Kinesin light chain

1

15

High-throughput

0.575

High

553768

MYCL
Protein L-Myc

2

8

High-throughput

0.574

High

1449437

COG6
Conserved oligomeric Golgi complex subunit 6

2

2

High-throughput

0.574

High

894194

MEOX2
Homeobox protein MOX-2

1

3

High-throughput

0.573

High

1315791

CE57L
Centrosomal protein CEP57L1

1

3

High-throughput

0.573

High

1449426

ABI3
ABI gene family member 3

1

6

High-throughput

0.573

High

300509

KRT34
Keratin, type I cuticular Ha4

2

15

High-throughput

0.553

High

476403

K1C16
Keratin, type I cytoskeletal 16

2

16

High-throughput

0.553

High

1127686

KT33B
Keratin, type I cuticular Ha3-II

2

17

High-throughput

0.553

High

1240822

ZN343
Zinc finger protein 343

2

1

High-throughput

0.553

High

1449435

ANC2
Anaphase-promoting complex subunit 2

1

12

High-throughput

0.553

High

1365008

TSC1
Hamartin

1

5

High-throughput

0.541

High

244189

KIF5C
Kinesin heavy chain isoform 5C

1

20

High-throughput

0.536

High

245747

GANP
Germinal-center associated nuclear protein

1

2

High-throughput

0.536

High

324051

CSTN1
Calsyntenin-1

1

9

High-throughput

0.536

High

539098

UMPS
Uridine 5'-monophosphate synthase

1

1

High-throughput

0.536

High

549697

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

3

High-throughput

0.536

High

682627

S100P
Protein S100-P

1

9

High-throughput

0.536

High

789232

NUP62
Nuclear pore glycoprotein p62

1

6

High-throughput

0.536

High

839383

MTOR
Serine/threonine-protein kinase mTOR

1

2

High-throughput

0.536

High

1140921

KIF14
Kinesin-like protein KIF14

1

17

High-throughput

0.536

High

1449436

TRAK1
Trafficking kinesin-binding protein 1

1

14

High-throughput

0.536

High

283557

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.523

High

618119

K1C15
Keratin, type I cytoskeletal 15

1

12

High-throughput

0.523

High

1274103

MOT9
Monocarboxylate transporter 9

1

1

High-throughput

0.523

High

1330093

USBP1
Harmonin-binding protein USHBP1

1

5

High-throughput

0.523

High

730915

1433S
14-3-3 protein sigma

1

20

High-throughput

0.515

High

1033432

CDR2
Cerebellar degeneration-related protein 2

1

0

High-throughput

0.513

High

217531

E41L2
Band 4.1-like protein 2

1

2

High-throughput

0.489

High

706330

S10A2
Protein S100-A2

1

9

High-throughput

0.489

High

897991

CDK9
Cyclin-dependent kinase 9

1

5

High-throughput

0.489

High

907944

PLXA3
Plexin-A3

1

1

High-throughput

0.489

High

1034701

MEF2A
Myocyte-specific enhancer factor 2A

1

1

High-throughput

0.489

High

1179868

INSY1
Inhibitory synaptic factor 1

1

1

High-throughput

0.489

High

1230349

K1C39
Keratin, type I cytoskeletal 39

1

15

High-throughput

0.489

High

1289656

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.489

High

1315637

ENTD1
ENTH domain-containing protein 1

1

1

High-throughput

0.489

High

1357216

BRK1
Protein BRICK1

1

1

High-throughput

0.489

High

1449428

CLIP2
CAP-Gly domain-containing linker protein 2

1

4

High-throughput

0.489

High

168757

CSKP
Peripheral plasma membrane protein CASK

1

8

High-throughput

0.481

High

223363

PRC1
Protein regulator of cytokinesis 1

1

2

High-throughput

0.481

High

684411

DDX6
Probable ATP-dependent RNA helicase DDX6

1

3

High-throughput

0.481

High

911126

IMA1
Importin subunit alpha-1

1

5

High-throughput

0.481

High

1143554

PCM1
Pericentriolar material 1 protein

1

1

High-throughput

0.481

High

1218022

MYOME
Myomegalin

1

6

High-throughput

0.481

High

1399763

RBM14
RNA-binding protein 14

1

5

High-throughput

0.481

High

1408343

PKP2
Plakophilin-2

1

7

High-throughput

0.481

High

437366

K2C8
Keratin, type II cytoskeletal 8

1

5

High-throughput

0.479

High

582982

EZRI
Ezrin

1

2

High-throughput

0.479

High

1255727

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.479

High

1291588

HOOK3
Protein Hook homolog 3

1

10

High-throughput

0.479

High

1368147

HDAC2
Histone deacetylase 2

1

5

High-throughput

0.479

High

1385397

ARMC5
Armadillo repeat-containing protein 5

1

6

High-throughput

0.479

High

1420952

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.479

High

1434003

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.479

High

1449429

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1449433

XPO7
Exportin-7

1

4

High-throughput

0.479

High

1449434

HOOK1
Protein Hook homolog 1

1

5

High-throughput

0.479

High

1155816

EZH2
Histone-lysine N-methyltransferase EZH2

1

10

High-throughput

0.470

High

49910

A1A4E9
Keratin 13

1

14

High-throughput

0.470

High

800123

COIL
Coilin

1

2

High-throughput

0.464

High

1428200

NDEL1
Nuclear distribution protein nudE-like 1

1

0

High-throughput

0.460

High

530438

TAU
Microtubule-associated protein tau

1

10

High-throughput

0.445

High

935180

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.445

High

566315

K1C13
Keratin, type I cytoskeletal 13

1

14

High-throughput

0.439

High

1408544

AKAP9
A-kinase anchor protein 9

1

6

High-throughput

0.439

High

218827

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.437

High

342046

CEP43
Centrosomal protein 43

1

3

High-throughput

0.437

High

406697

MYCN
N-myc proto-oncogene protein

1

9

High-throughput

0.437

High

411077

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

4

High-throughput

0.437

High

412675

NTRK1
High affinity nerve growth factor receptor

1

13

High-throughput

0.437

High

475703

K1C19
Keratin, type I cytoskeletal 19

1

16

High-throughput

0.437

High

541707

FGFR1
Fibroblast growth factor receptor 1

1

15

High-throughput

0.437

High

1053462

FHI1A
FHF complex subunit HOOK-interacting protein 1A

1

10

High-throughput

0.437

High

1150182

TCEA2
Transcription elongation factor A protein 2

1

1

High-throughput

0.437

High

1219958

FHI2A
FHF complex subunit HOOK interacting protein 2A

1

10

High-throughput

0.437

High

1233517

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.437

High

1290243

FHI2B
FHF complex subunit HOOK-interacting protein 2B

1

10

High-throughput

0.437

High

1310879

LMTK2
Serine/threonine-protein kinase LMTK2

1

16

High-throughput

0.437

High

1368395

REQU
Zinc finger protein ubi-d4

1

6

High-throughput

0.437

High

1449425

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

3

High-throughput

0.437

High

1449432

PUF60
Poly(U)-binding-splicing factor PUF60

1

8

High-throughput

0.437

High

1449438

CBY1
Protein chibby homolog 1

1

2

High-throughput

0.437

High

369213

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

1332517

POC5
Centrosomal protein POC5

1

0

Small-scale

0.426

High

62598

S35F4
Solute carrier family 35 member F4

1

1

High-throughput

0.407

High

97115

E9PN18

1

7

High-throughput

0.407

High

1258592

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

5

High-throughput

0.407

High

1449427

S53A1
Solute carrier family 53 member 1

1

2

High-throughput

0.407

High

1328629

PAR16
Protein mono-ADP-ribosyltransferase PARP16

1

0

High-throughput

0.279

Low

1387132

HVCN1
Voltage-gated hydrogen channel 1

1

0

High-throughput

0.279

Low

1419186

NEUL
Neurolysin, mitochondrial

1

0

High-throughput

0.279

Low

1430723

OSBL5
Oxysterol-binding protein-related protein 5

1

0

High-throughput

0.279

Low

1449362

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

377744

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

976593

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025