HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: SOX6 (P35712)
Transcription factor SOX-6
Gene: SOX6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:2000726 - negative regulation of cardiac muscle cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 428 Hs			1 828
+	Hs
		727863 HDAC1_HUMAN (3-385): 0: 588: 62.92		SOX6_HUMAN (1-828): 0: 640: 100.00
+	Hs
		727903 HDAC2_HUMAN (3-422): 0: 580: 58.63		SOX6_HUMAN (1-828): 0: 640: 100.00
+	Mm
		140309 HDAC1_MOUSE (3-385): 0: 588: 62.92		TF7L2_MOUSE (326-711): 8.29e-43: 164: 12.92
+	Hs
		1038578 HDAC1_HUMAN (3-385): 0: 588: 62.92		BBX_HUMAN (609-825): 3.46e-40: 161: 17.12
+	Hs
		1038645 HDAC1_HUMAN (3-385): 0: 588: 62.92		CIC_HUMAN (323-827): 1.48e-39: 161: 15.33
+	Hs
		1038795 HDAC1_HUMAN (3-385): 0: 588: 62.92		LEF1_HUMAN (384-715): 3e-41: 158: 16.72
+	Hs
		177229 HDAC3_HUMAN (1-428): 0: 600: 100.00		SOX2_HUMAN (587-707): 3.88e-37: 144: 38.02
+	Rn
		1118086 HDAC1_RAT (3-385): 0: 588: 62.92		LEF1_RAT (383-715): 1.41e-39: 153: 16.67
+	Mm
		1142019 Q9JM08_MOUSE (1-428): 0: 595: 99.07		Q60I23_MOUSE (582-707): 1.71e-36: 142: 38.10
+	Hs
		233836 HDAC1_HUMAN (3-385): 0: 588: 62.92		HBP1_HUMAN (515-703): 1.53e-36: 146: 23.28
+	Hs
		818023 HDAC1_HUMAN (3-385): 0: 588: 62.92		SOX2_HUMAN (587-707): 3.88e-37: 144: 38.02
+	Mm
		140296 HDAC1_MOUSE (3-385): 0: 588: 62.92		NSD2_MOUSE (500-828): 2.9e-34: 143: 11.47
+	Mm
		140241 HDAC1_MOUSE (3-385): 0: 588: 62.92		SOX2_MOUSE (582-707): 1.37e-36: 142: 38.10
+	Mm
		140273 HDAC1_MOUSE (3-385): 0: 588: 62.92		Q60I23_MOUSE (582-707): 1.71e-36: 142: 38.10
+	Mm
		140321 HDAC1_MOUSE (3-385): 0: 588: 62.92		TF7L1_MOUSE (415-826): 1.01e-34: 142: 12.09
+	Hs
		883315 HDAC1_HUMAN (3-385): 0: 588: 62.92		SOX8_HUMAN (553-708): 3.8e-35: 141: 30.38
+	Hs
		1038736 HDAC1_HUMAN (3-385): 0: 588: 62.92		HM20A_HUMAN (527-717): 8.51e-35: 138: 12.95
+	Hs
		818314 HDAC2_HUMAN (3-422): 0: 580: 58.63		SOX2_HUMAN (587-707): 3.88e-37: 144: 38.02
+	Xl
		1193361 Q7ZYT5_XENLA (3-422): 0: 594: 58.16		Q90ZB8_XENLA (391-716): 3.58e-31: 128: 13.64
+	Hs
		177269 HDAC3_HUMAN (1-428): 0: 600: 100.00		SRY_HUMAN (574-753): 1e-29: 118: 26.92