Protein: ANFY1
Rabankyrin-5 (Rank-5) (Ankyrin repeat and FYVE domain-containing protein 1) (Ankyrin repeats hooked to a zinc finger motif)

Gene: ANFY1, ANKFY1
Organism: Homo sapiens
Interactions: 215
UniProt ID: Q9P2R3

Gene Ontology (top 5):
GO:0005765 - lysosomal membrane
GO:0005768 - endosome
GO:0005769 - early endosome
GO:0005829 - cytosol
GO:0006897 - endocytosis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

631530

RAB5A
Ras-related protein Rab-5A

3

3

Small-scale

0.876

High

1451408

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

3

12

High-throughput

0.871

High

177322

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

2

13

High-throughput

0.793

High

1114526

CUL3
Cullin-3

2

9

Small-scale

0.789

High

1277481

ZFY16
Zinc finger FYVE domain-containing protein 16

2

9

Small-scale

0.754

High

126851

RHOD
Rho-related GTP-binding protein RhoD

1

10

Small-scale

0.740

High

1218395

ARHGG
Rho guanine nucleotide exchange factor 16

2

9

High-throughput

0.737

High

1438215

RHOF
Rho-related GTP-binding protein RhoF

1

10

Small-scale

0.713

High

239339

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

19

High-throughput

0.691

High

909222

NEK4
Serine/threonine-protein kinase Nek4

1

6

High-throughput

0.691

High

1325145

MILK1
MICAL-like protein 1

1

12

Small-scale

0.691

High

1434392

EHD1
EH domain-containing protein 1

3

12

Small-scale

0.684

High

1331017

ANR44
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

2

15

High-throughput

0.659

High

1006772

SRPK2
SRSF protein kinase 2

1

6

High-throughput

0.647

High

278573

VAMP4
Vesicle-associated membrane protein 4

1

2

High-throughput

0.618

High

299588

TRIO
Triple functional domain protein

1

20

High-throughput

0.618

High

336141

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

10

High-throughput

0.618

High

349277

LATS1
Serine/threonine-protein kinase LATS1

1

2

High-throughput

0.618

High

363961

EGFR
Epidermal growth factor receptor

1

11

Small-scale

0.618

High

541734

FGFR1
Fibroblast growth factor receptor 1

1

15

High-throughput

0.618

High

584595

VAV
Proto-oncogene vav

1

5

High-throughput

0.618

High

908867

NEK2
Serine/threonine-protein kinase Nek2

1

5

Small-scale

0.618

High

913606

KIF11
Kinesin-like protein KIF11

1

4

High-throughput

0.618

High

989392

VAMP2
Vesicle-associated membrane protein 2

1

3

High-throughput

0.618

High

1022835

RHG04
Rho GTPase-activating protein 4

1

10

High-throughput

0.618

High

1093199

STK4
Serine/threonine-protein kinase 4

1

8

High-throughput

0.618

High

1097756

STK3
Serine/threonine-protein kinase 3

1

8

High-throughput

0.618

High

1122820

DOCK1
Dedicator of cytokinesis protein 1

1

7

High-throughput

0.618

High

1141993

EEA1
Early endosome antigen 1

1

8

High-throughput

0.618

High

1154774

VAMP3
Vesicle-associated membrane protein 3

1

2

High-throughput

0.618

High

1157568

PKN2
Serine/threonine-protein kinase N2

1

1

High-throughput

0.618

High

1187591

AR13B
ADP-ribosylation factor-like protein 13B

1

4

High-throughput

0.618

High

1255911

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.618

High

1280565

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

9

High-throughput

0.618

High

1396904

KI16B
Kinesin-like protein KIF16B

1

3

High-throughput

0.618

High

1402169

KS6C1
Ribosomal protein S6 kinase delta-1

1

2

High-throughput

0.618

High

1403363

RUFY1
RUN and FYVE domain-containing protein 1

1

11

High-throughput

0.618

High

1431141

RBNS5
Rabenosyn-5

1

6

High-throughput

0.618

High

1438994

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

8

High-throughput

0.618

High

1449215

KIF15
Kinesin-like protein KIF15

1

3

High-throughput

0.618

High

1453539

PD1L1
Programmed cell death 1 ligand 1

1

4

Small-scale

0.618

High

1454798

KDIS
Kinase D-interacting substrate of 220 kDa

1

14

High-throughput

0.618

High

1155852

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.595

High

192337

YKT6
Synaptobrevin homolog YKT6

1

0

High-throughput

0.586

High

409524

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

0

High-throughput

0.586

High

762062

GRK5
G protein-coupled receptor kinase 5

1

0

High-throughput

0.586

High

243178

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

1428399

MLP3B
Microtubule-associated protein 1 light chain 3 beta

2

15

High-throughput

0.584

High

1432908

PTN23
Tyrosine-protein phosphatase non-receptor type 23

2

4

Small-scale

0.584

High

889516

CLK1
Dual specificity protein kinase CLK1

1

3

High-throughput

0.579

High

1234761

SPOPL
Speckle-type POZ protein-like

1

0

High-throughput

0.578

High

1209750

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.575

High

1295398

MF2L2
Probable guanine nucleotide exchange factor MCF2L2

2

12

High-throughput

0.571

High

174845

MAST4
Microtubule-associated serine/threonine-protein kinase 4

1

1

High-throughput

0.553

High

348220

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

11

High-throughput

0.553

High

710538

EPHA2
Ephrin type-A receptor 2

1

10

High-throughput

0.553

High

1085116

KIF1A
Kinesin-like protein KIF1A

1

4

High-throughput

0.553

High

1115111

CUL4A
Cullin-4A

1

9

High-throughput

0.553

High

136009

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

1

High-throughput

0.536

High

328181

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

15

High-throughput

0.536

High

952372

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

15

High-throughput

0.536

High

1039828

CREB5
Cyclic AMP-responsive element-binding protein 5

1

2

High-throughput

0.536

High

1338640

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

7

High-throughput

0.536

High

1400936

VPS35
Vacuolar protein sorting-associated protein 35

1

1

Small-scale

0.536

High

1253674

PKHG7
Pleckstrin homology domain-containing family G member 7

2

12

High-throughput

0.521

High

1025298

CDK3
Cyclin-dependent kinase 3

1

0

High-throughput

0.517

High

289044

ERAL1
GTPase Era, mitochondrial

1

0

High-throughput

0.513

High

1180662

AP5B1
AP-5 complex subunit beta-1

1

0

High-throughput

0.513

High

1369079

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.513

High

1412241

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.513

High

1453482

EHD3
EH domain-containing protein 3

1

12

Small-scale

0.506

High

508758

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.501

High

1429057

PRD14
PR domain zinc finger protein 14

1

2

Small-scale

0.500

High

1415894

DDA1
DET1- and DDB1-associated protein 1

1

1

High-throughput

0.489

High

1454166

CAMP3
Calmodulin-regulated spectrin-associated protein 3

1

10

High-throughput

0.489

High

216198

MTG8R
Protein CBFA2T2

1

0

Small-scale

0.479

High

51118

PKHG3
Pleckstrin homology domain-containing family G member 3

1

7

High-throughput

0.479

High

62065

WDR91
WD repeat-containing protein 91

1

8

High-throughput

0.479

High

67807

TBKB1
TANK-binding kinase 1-binding protein 1

1

6

High-throughput

0.479

High

159405

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

9

High-throughput

0.479

High

159897

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

7

High-throughput

0.479

High

166433

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

4

High-throughput

0.479

High

178851

SCAM1
Secretory carrier-associated membrane protein 1

1

1

High-throughput

0.479

High

189898

STX7
Syntaxin-7

1

4

High-throughput

0.479

High

215953

SYNJ1
Synaptojanin-1

1

1

High-throughput

0.479

High

224818

ACTN4
Alpha-actinin-4

1

9

High-throughput

0.479

High

226241

STX6
Syntaxin-6

1

2

High-throughput

0.479

High

249676

SNX3
Sorting nexin-3

1

6

High-throughput

0.479

High

252491

DIAP1
Protein diaphanous homolog 1

1

2

High-throughput

0.479

High

255494

SNX2
Sorting nexin-2

1

6

High-throughput

0.479

High

320111

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

324227

CE152
Centrosomal protein of 152 kDa

1

7

High-throughput

0.479

High

340256

PCNT
Pericentrin

1

17

High-throughput

0.479

High

346439

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

404503

GCR
Glucocorticoid receptor

1

6

High-throughput

0.479

High

412738

NTRK1
High affinity nerve growth factor receptor

1

13

High-throughput

0.479

High

459783

PROF1
Profilin-1

1

3

High-throughput

0.479

High

651447

CBL
E3 ubiquitin-protein ligase CBL

1

4

High-throughput

0.479

High

696743

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

714481

PML
Protein PML

1

7

High-throughput

0.479

High

731663

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

971225

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

1037052

DSC2
Desmocollin-2

1

2

High-throughput

0.479

High

1041341

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

1061313

RHG01
Rho GTPase-activating protein 1

1

6

High-throughput

0.479

High

1105672

GOGA4
Golgin subfamily A member 4

1

10

High-throughput

0.479

High

1110138

HDAC1
Histone deacetylase 1

1

6

High-throughput

0.479

High

1120585

LRP8
Low-density lipoprotein receptor-related protein 8

1

2

High-throughput

0.479

High

1120836

DSG2
Desmoglein-2

1

2

High-throughput

0.479

High

1124934

FLOT2
Flotillin-2

1

2

High-throughput

0.479

High

1159888

OCLN
Occludin

1

2

High-throughput

0.479

High

1161727

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

1208075

CYTSB
Cytospin-B

1

13

High-throughput

0.479

High

1213095

RHG21
Rho GTPase-activating protein 21

1

8

High-throughput

0.479

High

1229732

VIR
Protein virilizer homolog

1

3

High-throughput

0.479

High

1241129

C2D1A
Coiled-coil and C2 domain-containing protein 1A

1

6

High-throughput

0.479

High

1251970

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.479

High

1275732

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

8

High-throughput

0.479

High

1288597

ZN598
E3 ubiquitin-protein ligase ZNF598

1

4

High-throughput

0.479

High

1294851

STX12
Syntaxin-12

1

4

High-throughput

0.479

High

1295353

CPNE8
Copine-8

1

3

High-throughput

0.479

High

1310177

GCC2
GRIP and coiled-coil domain-containing protein 2

1

11

High-throughput

0.479

High

1330964

CGAS
Cyclic GMP-AMP synthase

1

1

High-throughput

0.479

High

1337805

DP13B
DCC-interacting protein 13-beta

1

4

High-throughput

0.479

High

1350195

ALMS1
Centrosome-associated protein ALMS1

1

12

High-throughput

0.479

High

1368657

KAT6A
Histone acetyltransferase KAT6A

1

6

High-throughput

0.479

High

1371464

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

6

High-throughput

0.479

High

1381405

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

1

Small-scale

0.479

High

1384463

PF21A
PHD finger protein 21A

1

7

High-throughput

0.479

High

1396844

SNX27
Sorting nexin-27

1

11

High-throughput

0.479

High

1407928

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

1417419

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

1

15

High-throughput

0.479

High

1420823

TB182
182 kDa tankyrase-1-binding protein

1

19

High-throughput

0.479

High

1421268

RHG39
Rho GTPase-activating protein 39

1

8

High-throughput

0.479

High

1430086

RGAP1
Rac GTPase-activating protein 1

1

9

High-throughput

0.479

High

1430354

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

15

High-throughput

0.479

High

1431914

S38A1
Sodium-coupled neutral amino acid symporter 1

1

1

High-throughput

0.479

High

1435768

AT133
Polyamine-transporting ATPase 13A3

1

1

High-throughput

0.479

High

1437778

XPO5
Exportin-5

1

8

High-throughput

0.479

High

1438062

RC3H2
Roquin-2

1

12

High-throughput

0.479

High

1446986

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

1448936

VPS45
Vacuolar protein sorting-associated protein 45

1

1

High-throughput

0.479

High

1453491

ARHGC
Rho guanine nucleotide exchange factor 12

1

10

High-throughput

0.479

High

1454231

RHG23
Rho GTPase-activating protein 23

1

11

High-throughput

0.479

High

1454340

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

2

High-throughput

0.479

High

1454793

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1454795

LCAP
Leucyl-cystinyl aminopeptidase

1

2

High-throughput

0.479

High

1454796

CDC23
Cell division cycle protein 23 homolog

1

2

High-throughput

0.479

High

1454799

SNX6
Sorting nexin-6

1

6

High-throughput

0.479

High

1454800

STX8
Syntaxin-8

1

2

High-throughput

0.479

High

1454802

FARP1
FERM, ARHGEF and pleckstrin domain-containing protein 1

1

10

High-throughput

0.479

High

1454803

SNX9
Sorting nexin-9

1

5

High-throughput

0.479

High

1454804

SNX5
Sorting nexin-5

1

5

High-throughput

0.479

High

1208153

CD158
Coiled-coil domain-containing protein 158

1

10

High-throughput

0.470

High

49131

BLT3B
Bridge-like lipid transfer protein family member 3B

1

0

High-throughput

0.458

High

124119

SNP23
Synaptosomal-associated protein 23

1

0

High-throughput

0.458

High

281793

VP26A
Vacuolar protein sorting-associated protein 26A

1

0

Small-scale

0.458

High

300058

CBPD
Carboxypeptidase D

1

0

High-throughput

0.458

High

344429

TBCD8
TBC1 domain family member 8

1

0

High-throughput

0.458

High

390794

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

467637

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.458

High

548626

MPRI
Cation-independent mannose-6-phosphate receptor

1

0

High-throughput

0.458

High

844235

ECE1
Endothelin-converting enzyme 1

1

0

High-throughput

0.458

High

933493

S12A2
Solute carrier family 12 member 2

1

0

High-throughput

0.458

High

957537

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

1148218

DLGP5
Disks large-associated protein 5

1

0

High-throughput

0.458

High

1224810

AP1AR
AP-1 complex-associated regulatory protein

1

0

High-throughput

0.458

High

1225926

STEA3
Metalloreductase STEAP3

1

0

High-throughput

0.458

High

1325284

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

0

High-throughput

0.458

High

1339293

RAI3
Retinoic acid-induced protein 3

1

0

High-throughput

0.458

High

1405222

MPP9
M-phase phosphoprotein 9

1

0

High-throughput

0.458

High

1420451

SPY4
Protein sprouty homolog 4

1

0

High-throughput

0.458

High

1431331

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

1431951

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

0

High-throughput

0.458

High

1454318

SLAI2
SLAIN motif-containing protein 2

1

0

High-throughput

0.458

High

1454794

ABC3B
DNA dC->dU-editing enzyme APOBEC-3B

1

0

Small-scale

0.458

High

1454801

MEMO1
Protein MEMO1

1

0

High-throughput

0.458

High

530495

TAU
Microtubule-associated protein tau

1

9

High-throughput

0.445

High

1094435

CSN1
COP9 signalosome complex subunit 1

1

2

High-throughput

0.445

High

1367479

ESR2
Estrogen receptor beta

1

6

High-throughput

0.445

High

176092

KDM6B
Lysine-specific demethylase 6B

1

7

Small-scale

0.437

High

247002

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.437

High

257515

PAGE4
P antigen family member 4

1

3

High-throughput

0.437

High

294464

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

373379

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.437

High

589924

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

769400

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1047941

TLE2
Transducin-like enhancer protein 2

1

8

High-throughput

0.437

High

1135834

HAPR1
HUWE1-associated protein modifying stress responses 1

1

2

High-throughput

0.437

High

1157263

AINX
Alpha-internexin

1

12

High-throughput

0.437

High

1213047

CC183
Coiled-coil domain-containing protein 183

1

2

High-throughput

0.437

High

1216534

BIG3
Brefeldin A-inhibited guanine nucleotide-exchange protein 3

1

4

High-throughput

0.437

High

1253750

RHG36
Rho GTPase-activating protein 36

1

10

High-throughput

0.437

High

1326805

ARG39
Rho guanine nucleotide exchange factor 39

1

11

High-throughput

0.437

High

1331768

JMY
Junction-mediating and -regulatory protein

1

2

High-throughput

0.437

High

1332394

TTC29
Tetratricopeptide repeat protein 29

1

1

High-throughput

0.437

High

1351398

DLG5
Disks large homolog 5

1

4

High-throughput

0.437

High

1353016

SNX29
Sorting nexin-29

1

4

High-throughput

0.437

High

1357437

DEP1B
DEP domain-containing protein 1B

1

6

High-throughput

0.437

High

1400733

S38A2
Sodium-coupled neutral amino acid symporter 2

1

1

High-throughput

0.437

High

1434115

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.437

High

1439274

K1549
UPF0606 protein KIAA1549

1

7

High-throughput

0.437

High

1454562

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

2

High-throughput

0.437

High

1454797

RCOR1
REST corepressor 1

1

3

High-throughput

0.437

High

240164

FGF17
Fibroblast growth factor 17

1

14

High-throughput

0.407

High

1450361

SEP11
Septin-11

1

1

High-throughput

0.407

High

1332466

SAXO5
Stabilizer of axonemal microtubules 5

2

0

High-throughput

0.328

High

276191

NIPS2
Protein NipSnap homolog 2

1

0

High-throughput

0.279

Low

1065474

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.279

Low

1219921

USPL1
SUMO-specific isopeptidase USPL1

1

0

High-throughput

0.279

Low

835019

S19A1
Reduced folate transporter

1

0

High-throughput

0.249

Low

1103424

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.249

Low

1136108

PAF15
PCNA-associated factor

1

0

Small-scale

0.249

Low

1454498

F135A
Protein FAM135A

1

0

High-throughput

0.249

Low

87550

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025