HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: Q15156 (Q15156)
PML-RAR protein
Gene: PML-RAR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	16432238
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 428 Hs			1 797
+	Hs
		177215 HDAC3_HUMAN (1-428): 0: 600: 100.00		PPARG_HUMAN (378-751): 2.01e-120: 374: 30.02
+	Mm
		740726 Q9JM08_MOUSE (1-428): 0: 595: 99.07		PPARG_MOUSE (378-751): 1.1e-118: 369: 30.27
+	Hs
		740520 HDAC1_HUMAN (3-385): 0: 588: 62.92		PPARG_HUMAN (378-751): 2.01e-120: 374: 30.02
+	Mm
		140239 HDAC1_MOUSE (3-385): 0: 588: 62.92		PPARG_MOUSE (378-751): 1.1e-118: 369: 30.27
+	Hs
		177191 HDAC3_HUMAN (1-428): 0: 600: 100.00		RXRA_HUMAN (358-755): 8.24e-107: 337: 28.07
+	Hs
		177175 HDAC3_HUMAN (1-428): 0: 600: 100.00		RARA_HUMAN (350-797): 2.03e-106: 336: 90.40
+	Hs
		177223 HDAC3_HUMAN (1-428): 0: 600: 100.00		HNF4A_HUMAN (384-797): 7.78e-106: 335: 23.29
+	Mm
		140236 HDAC1_MOUSE (3-385): 0: 588: 62.92		RXRA_MOUSE (358-752): 1.21e-107: 339: 28.54
+	Hs
		487964 HDAC1_HUMAN (3-385): 0: 588: 62.92		RARA_HUMAN (350-797): 2.03e-106: 336: 90.40
+	Hs
		177166 HDAC3_HUMAN (1-428): 0: 600: 100.00		ESR1_HUMAN (336-795): 6.4e-97: 315: 20.89
+	Hs
		369550 HDAC1_HUMAN (3-385): 0: 588: 62.92		ESR1_HUMAN (336-795): 6.4e-97: 315: 20.89
+	Hs
		177209 HDAC3_HUMAN (1-428): 0: 600: 100.00		PML_HUMAN (1-413): 7.06e-89: 301: 96.37
+	Hs
		622790 HDAC1_HUMAN (3-385): 0: 588: 62.92		COT2_HUMAN (397-756): 1.08e-93: 301: 28.10
+	Hs
		668659 HDAC1_HUMAN (3-385): 0: 588: 62.92		PML_HUMAN (1-413): 7.06e-89: 301: 96.37
+	Hs
		177178 HDAC3_HUMAN (1-428): 0: 600: 100.00		THB_HUMAN (353-751): 4.43e-87: 285: 32.24
+	Mm
		140277 HDAC1_MOUSE (3-385): 0: 588: 62.92		ERR2_MOUSE (405-752): 2.18e-90: 293: 29.02
+	Hs
		177343 HDAC3_HUMAN (1-428): 0: 600: 100.00		ESR2_HUMAN (343-781): 1.46e-84: 280: 22.83
+	Hs
		611437 HDAC1_HUMAN (3-385): 0: 588: 62.92		NR4A1_HUMAN (327-755): 4.98e-88: 291: 27.78
+	Hs
		177177 HDAC3_HUMAN (1-428): 0: 600: 100.00		THA_HUMAN (423-727): 9.32e-60: 212: 37.46
+	Hs
		177266 HDAC3_HUMAN (1-428): 0: 600: 100.00		PPARD_HUMAN (423-751): 6.43e-46: 172: 31.35