HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29509190
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0019899 - enzyme binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 428 Hs			1 530
+	Hs
		1038589 HDAC1_HUMAN (3-385): 0: 588: 62.92		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		177166 HDAC3_HUMAN (1-428): 0: 600: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369550 HDAC1_HUMAN (3-385): 0: 588: 62.92		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370134 HDAC2_HUMAN (3-422): 0: 580: 58.63		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Mm
		140236 HDAC1_MOUSE (3-385): 0: 588: 62.92		RXRA_MOUSE (17-498): 5.77e-124: 373: 26.24
+	Hs
		177191 HDAC3_HUMAN (1-428): 0: 600: 100.00		RXRA_HUMAN (13-502): 1.6e-119: 361: 25.71
+	Hs
		177299 HDAC3_HUMAN (1-428): 0: 600: 100.00		Q15156_HUMAN (144-499): 1.55e-105: 335: 26.33
+	Hs
		177223 HDAC3_HUMAN (1-428): 0: 600: 100.00		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		177175 HDAC3_HUMAN (1-428): 0: 600: 100.00		RARA_HUMAN (52-505): 3.54e-105: 324: 23.74
+	Hs
		377304 HDAC1_HUMAN (3-385): 0: 588: 62.92		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Mm
		140277 HDAC1_MOUSE (3-385): 0: 588: 62.92		ERR2_MOUSE (69-499): 5.26e-107: 328: 31.11
+	Hs
		487964 HDAC1_HUMAN (3-385): 0: 588: 62.92		RARA_HUMAN (52-505): 3.54e-105: 324: 23.74
+	Hs
		377552 HDAC2_HUMAN (3-422): 0: 580: 58.63		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		611437 HDAC1_HUMAN (3-385): 0: 588: 62.92		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Hs
		622790 HDAC1_HUMAN (3-385): 0: 588: 62.92		COT2_HUMAN (77-502): 2.24e-102: 316: 23.90
+	Hs
		177174 HDAC3_HUMAN (1-428): 0: 600: 100.00		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Mm
		292417 HDAC3_MOUSE (1-428): 0: 601: 99.77		NR2E1_MOUSE (149-408): 2.11e-35: 138: 31.82
+	Hs
		487410 HDAC1_HUMAN (3-385): 0: 588: 62.92		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		177412 HDAC3_HUMAN (1-428): 0: 600: 100.00		NR2E1_HUMAN (149-408): 2.63e-35: 137: 31.82
+	Hs
		1038843 HDAC1_HUMAN (3-385): 0: 588: 62.92		NR2E1_HUMAN (149-408): 2.63e-35: 137: 31.82