HitPredict

Interactor 1: STX7 (O15400)
Syntaxin-7
Gene: STX7

Interactor 2: VAMP5 (O95183)
Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)
Gene: VAMP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	30833792, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin
Common GO terms	GO:0005770 - late endosome GO:0005886 - plasma membrane GO:0048471 - perinuclear region of cytoplasm GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 261 Hs			1 116
+	Mm
		936372 Q8BH40_MOUSE (1-259): 1.02e-74: 229: 94.98		VAMP7_MOUSE (4-94): 1.74e-25: 96.9: 31.87
+	Hs
		306763 STX2_HUMAN (7-256): 2.04e-65: 207: 27.13		VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00
+	Mm
		926344 Q8BH40_MOUSE (1-259): 1.02e-74: 229: 94.98		VAMP2_MOUSE (2-75): 2.33e-25: 93.8: 39.19
+	Mm
		250785 Q8BH40_MOUSE (1-259): 1.02e-74: 229: 94.98		VAMP8_MOUSE (2-69): 1.29e-24: 91.1: 27.94
+	Mm
		926191 Q8BH40_MOUSE (1-259): 1.02e-74: 229: 94.98		VAMP3_MOUSE (2-69): 2.48e-24: 90.7: 39.71
+	Mm
		250840 STX7_MOUSE (1-259): 1.22e-72: 224: 94.21		VAMP2_MOUSE (2-75): 2.33e-25: 93.8: 39.19
+	Hs
		178445 STX7_HUMAN (1-261): 9.25e-70: 217: 100.00		VAMP7_HUMAN (4-96): 5.88e-26: 98: 31.18
+	Hs
		178330 STX7_HUMAN (1-261): 9.25e-70: 217: 100.00		VAMP4_HUMAN (3-73): 1.13e-25: 95.3: 29.58
+	Hs
		178753 STX7_HUMAN (1-261): 9.25e-70: 217: 100.00		VAMP8_HUMAN (2-74): 9.04e-26: 94.2: 26.03
+	Hs
		178472 STX7_HUMAN (1-261): 9.25e-70: 217: 100.00		VAMP2_HUMAN (2-75): 2.33e-25: 93.8: 39.19
+	Hs
		178331 STX7_HUMAN (1-261): 9.25e-70: 217: 100.00		SC22B_HUMAN (2-86): 2.38e-23: 91.1: 17.65
+	Hs
		178551 STX7_HUMAN (1-261): 9.25e-70: 217: 100.00		VAMP3_HUMAN (2-72): 2.01e-24: 90.7: 38.03
+	Hs
		699284 STX2_HUMAN (7-256): 2.04e-65: 207: 27.13		VAMP8_HUMAN (2-74): 9.04e-26: 94.2: 26.03
+	Hs
		699254 STX2_HUMAN (7-256): 2.04e-65: 207: 27.13		VAMP2_HUMAN (2-75): 2.33e-25: 93.8: 39.19
+	Mm
		192845 STX1A_MOUSE (7-259): 3.19e-65: 206: 24.90		VAMP2_MOUSE (2-75): 2.33e-25: 93.8: 39.19
+	Rn
		699175 STX1A_RAT (7-259): 2.77e-65: 206: 24.90		VAMP2_RAT (2-75): 2.33e-25: 93.8: 39.19
+	Hs
		263179 STX2_HUMAN (7-256): 2.04e-65: 207: 27.13		SC22B_HUMAN (2-86): 2.38e-23: 91.1: 17.65
+	Hs
		699263 STX2_HUMAN (7-256): 2.04e-65: 207: 27.13		VAMP3_HUMAN (2-72): 2.01e-24: 90.7: 38.03
+	Mm
		139056 STX1A_MOUSE (7-259): 3.19e-65: 206: 24.90		SC22B_MOUSE (2-86): 2.38e-23: 91.1: 17.65
+	Hs
		87579 STX7_HUMAN (1-261): 9.25e-70: 217: 100.00		C9JXZ5_HUMAN (20-73): 3.33e-19: 76.9: 29.63