Protein: SCAP
Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein)

Gene: SCAP
Organism: Homo sapiens
Interactions: 139
UniProt ID: Q12770

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001666 - response to hypoxia
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

192487

INSI1
Insulin-induced gene 1 protein

11

3

Small-scale

0.972

High

1085410

INSI2
Insulin-induced gene 2 protein

4

3

Small-scale

0.867

High

787864

SRBP1
Sterol regulatory element-binding protein 1

4

17

Small-scale

0.686

High

1085313

SRBP2
Sterol regulatory element-binding protein 2

3

18

Small-scale

0.656

High

219300

B4GA1
Beta-1,4-glucuronyltransferase 1

3

0

High-throughput

0.634

High

1085359

LPAR1
Lysophosphatidic acid receptor 1

4

10

High-throughput

0.630

High

1085357

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

12

High-throughput

0.628

High

1085386

ZDH11
Palmitoyltransferase ZDHHC11

2

4

High-throughput

0.601

High

321226

ERLN2
Erlin-2

2

9

Small-scale

0.584

High

1085401

AT1B4
Protein ATP1B4

2

4

High-throughput

0.558

High

161132

ABCD4
Lysosomal cobalamin transporter ABCD4

1

8

High-throughput

0.536

High

261165

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.536

High

399681

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

4

High-throughput

0.536

High

607921

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

3

High-throughput

0.536

High

698611

CALX
Calnexin

1

12

High-throughput

0.536

High

880532

LMAN1
Protein ERGIC-53

1

2

High-throughput

0.536

High

907705

CLCN3
H(+)/Cl(-) exchange transporter 3

1

1

High-throughput

0.536

High

911974

DGKE
Diacylglycerol kinase epsilon

1

3

High-throughput

0.536

High

930862

HSP72
Heat shock-related 70 kDa protein 2

1

13

High-throughput

0.536

High

1043200

TAP2
Antigen peptide transporter 2

1

5

High-throughput

0.536

High

1085314

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

1

5

High-throughput

0.536

High

1085319

NOMO1
BOS complex subunit NOMO1

1

1

High-throughput

0.536

High

1085320

CP51A
Lanosterol 14-alpha demethylase

1

3

High-throughput

0.536

High

1085322

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.536

High

1085323

S27A3
Long-chain fatty acid transport protein 3

1

4

High-throughput

0.536

High

1085325

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

1

High-throughput

0.536

High

1085328

RETST
All-trans-retinol 13,14-reductase

1

4

High-throughput

0.536

High

1085331

TMPPE
Transmembrane protein with metallophosphoesterase domain

1

1

High-throughput

0.536

High

1085333

LRP10
Low-density lipoprotein receptor-related protein 10

1

3

High-throughput

0.536

High

1085339

VRK2
Serine/threonine-protein kinase VRK2

1

14

High-throughput

0.536

High

1085340

ZDH13
Palmitoyltransferase ZDHHC13

1

5

High-throughput

0.536

High

1085341

ZDH17
Palmitoyltransferase ZDHHC17

1

12

High-throughput

0.536

High

1085342

GHDC
GH3 domain-containing protein

1

1

High-throughput

0.536

High

1085350

ST7L
Suppressor of tumorigenicity 7 protein-like

1

2

High-throughput

0.536

High

1085360

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

9

High-throughput

0.536

High

1085362

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.536

High

1085364

ZDH12
Palmitoyltransferase ZDHHC12

1

4

High-throughput

0.536

High

1085365

P121A
Nuclear envelope pore membrane protein POM 121

1

13

High-throughput

0.536

High

1085368

CP2S1
Cytochrome P450 2S1

1

2

High-throughput

0.536

High

1085374

GDF15
Growth/differentiation factor 15

1

7

High-throughput

0.536

High

1085377

CA043
Protein C1orf43

1

1

High-throughput

0.536

High

1085383

PCX3
Pecanex-like protein 3

1

9

High-throughput

0.536

High

1085388

SEC12
Guanine nucleotide-exchange factor SEC12

1

18

High-throughput

0.536

High

1085389

ST7
Suppressor of tumorigenicity 7 protein

1

2

High-throughput

0.536

High

1085390

AAAS
Aladin

1

17

High-throughput

0.536

High

1085396

ZDHC3
Palmitoyltransferase ZDHHC3

1

2

High-throughput

0.536

High

1085399

FBX2
F-box only protein 2

1

3

High-throughput

0.536

High

1085400

TSN16
Tetraspanin-16

1

3

High-throughput

0.536

High

1085404

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

2

High-throughput

0.536

High

1085406

DHRS7
Dehydrogenase/reductase SDR family member 7

1

3

High-throughput

0.536

High

1085408

TBL2
Transducin beta-like protein 2

1

18

High-throughput

0.536

High

1085409

PCDB3
Protocadherin beta-3

1

4

High-throughput

0.536

High

1085335

GLTL5
Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5

1

7

High-throughput

0.515

High

72655

UPK3L
Uroplakin-3b-like protein 1

1

0

High-throughput

0.513

High

155457

C2C2L
Phospholipid transfer protein C2CD2L

1

0

High-throughput

0.513

High

184984

SPTC2
Serine palmitoyltransferase 2

1

0

High-throughput

0.513

High

220124

SGCE
Epsilon-sarcoglycan

1

0

High-throughput

0.513

High

325544

YIF1A
Protein YIF1A

1

0

High-throughput

0.513

High

790150

PIGA
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

1

0

High-throughput

0.513

High

1085344

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.513

High

1085348

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.513

High

1085363

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.513

High

1085371

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.513

High

1085376

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.513

High

1085378

TMM59
Transmembrane protein 59

1

0

High-throughput

0.513

High

1085380

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

1085394

TM39A
Transmembrane protein 39A

1

0

High-throughput

0.513

High

338464

SC24B
Protein transport protein Sec24B

1

3

Small-scale

0.501

High

349412

TSN15
Tetraspanin-15

1

2

High-throughput

0.489

High

575650

GPIX
Platelet glycoprotein IX

1

5

High-throughput

0.489

High

855318

5HT3A
5-hydroxytryptamine receptor 3A

1

4

High-throughput

0.489

High

945892

INHBE
Inhibin beta E chain

1

4

High-throughput

0.489

High

1085316

MTR1L
Melatonin-related receptor

1

2

High-throughput

0.489

High

1085317

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

17

High-throughput

0.489

High

1085318

FZD2
Frizzled-2

1

4

High-throughput

0.489

High

1085353

THEM6
Protein THEM6

1

2

High-throughput

0.489

High

1085354

BT2A2
Butyrophilin subfamily 2 member A2

1

12

High-throughput

0.489

High

1085358

BRI3B
BRI3-binding protein

1

1

High-throughput

0.489

High

1085366

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

13

High-throughput

0.489

High

1085372

GPR21
Probable G-protein coupled receptor 21

1

4

High-throughput

0.489

High

1085387

LPAR2
Lysophosphatidic acid receptor 2

1

10

High-throughput

0.489

High

1085392

DDX28
Probable ATP-dependent RNA helicase DDX28

1

16

High-throughput

0.489

High

1085395

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

1

2

High-throughput

0.489

High

1085397

GPC5D
G-protein coupled receptor family C group 5 member D

1

2

High-throughput

0.489

High

218120

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.479

High

520823

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

7

High-throughput

0.479

High

643357

OSBP1
Oxysterol-binding protein 1

1

1

Small-scale

0.479

High

901209

RAB7A
Ras-related protein Rab-7a

1

11

High-throughput

0.479

High

1085315

SQSTM
Sequestosome-1

1

4

Small-scale

0.479

High

1085321

NADL2
Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2

1

1

High-throughput

0.479

High

1085329

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1085352

RN139
E3 ubiquitin-protein ligase RNF139

1

10

Small-scale

0.479

High

1085373

RNF5
E3 ubiquitin-protein ligase RNF5

1

8

Small-scale

0.479

High

1085384

SPRNG
SREBP regulating gene protein

1

1

Small-scale

0.479

High

1085391

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

1

Small-scale

0.479

High

1085398

VAPA
Vesicle-associated membrane protein-associated protein A

1

2

Small-scale

0.479

High

1085403

NUDC
Nuclear migration protein nudC

1

11

High-throughput

0.479

High

1085407

TRRAP
Transformation/transcription domain-associated protein

1

7

High-throughput

0.479

High

1085346

GOLM1
Golgi membrane protein 1

1

0

Small-scale

0.458

High

170741

CLGN
Calmegin

1

12

High-throughput

0.445

High

619764

VCAM1
Vascular cell adhesion protein 1

1

5

High-throughput

0.445

High

653279

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

886049

CXCR3
C-X-C chemokine receptor type 3

1

7

High-throughput

0.445

High

907086

CCR9
C-C chemokine receptor type 9

1

7

High-throughput

0.445

High

946549

EVA1C
Protein eva-1 homolog C

1

1

High-throughput

0.445

High

1085327

MFSD5
Molybdate-anion transporter

1

1

High-throughput

0.445

High

1085336

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

1

High-throughput

0.445

High

1085367

DIRC2
Solute carrier family 49 member 4

1

1

High-throughput

0.445

High

1085369

SL9A7
Sodium/hydrogen exchanger 7

1

1

High-throughput

0.445

High

1085381

TOR3A
Torsin-3A

1

1

High-throughput

0.445

High

1085405

S27A5
Long-chain fatty acid transport protein 5

1

4

High-throughput

0.445

High

658518

GLRA2
Glycine receptor subunit alpha-2

1

1

High-throughput

0.437

High

1051362

ZBT16
Zinc finger and BTB domain-containing protein 16

1

1

Small-scale

0.437

High

1085330

BTNL8
Butyrophilin-like protein 8

1

11

High-throughput

0.437

High

1085332

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

1085379

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

19

Small-scale

0.437

High

1085382

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.437

High

49522

SHSA3
Protein shisa-3 homolog

1

0

High-throughput

0.426

High

1085326

GP107
Protein GPR107

1

0

High-throughput

0.426

High

1085334

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

1

0

High-throughput

0.426

High

1085347

CTL5
Choline transporter-like protein 5

1

0

High-throughput

0.426

High

1085356

SSMM1
Serine-rich single-pass membrane protein 1

1

0

High-throughput

0.426

High

1085361

S67A1
Solute carrier family 67 member A1

1

0

High-throughput

0.426

High

702765

5HT2C
5-hydroxytryptamine receptor 2C

1

1

High-throughput

0.407

High

877658

SL9A3
Sodium/hydrogen exchanger 3

1

1

High-throughput

0.407

High

1085337

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

8

High-throughput

0.407

High

1085343

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.407

High

1085351

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

1

High-throughput

0.407

High

1085370

S1PR3
Sphingosine 1-phosphate receptor 3

1

11

High-throughput

0.407

High

1085375

ZNT2
Proton-coupled zinc antiporter SLC30A2

1

3

High-throughput

0.407

High

1085349

MCLN3
Mucolipin-3

3

0

High-throughput

0.347

High

1085385

IPPK
Inositol-pentakisphosphate 2-kinase

2

0

High-throughput

0.328

High

1085324

TM201
Transmembrane protein 201

1

0

High-throughput

0.279

Low

1085338

LSR
Lipolysis-stimulated lipoprotein receptor

1

0

High-throughput

0.279

Low

1085345

MYCT1
Myc target protein 1

1

0

High-throughput

0.279

Low

1085402

TNF18
Tumor necrosis factor ligand superfamily member 18

1

0

High-throughput

0.279

Low

293628

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

1085393

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1085355

CA054
Uncharacterized protein C1orf54

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025