HitPredict

Interactor 1: TLR3 (O15455)
Toll-like receptor 3 (CD antigen CD283)
Gene: TLR3

Interactor 2: SIGL9 (Q9Y336)
Sialic acid-binding Ig-like lectin 9 (Siglec-9) (CDw329) (Protein FOAP-9) (CD antigen CD329)
Gene: SIGLEC9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25187624
Identification Methods	enzyme linked immunosorbent assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_8~ig, LRR_8~V-set
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 904 Hs			1 463
+	Hs
		179969 TLR3_HUMAN (1-904): 2.14e-155: 481: 100.00		SIGL7_HUMAN (20-463): 5.28e-84: 268: 75.33
+	Hs
		179919 TLR3_HUMAN (1-904): 2.14e-155: 481: 100.00		SIGL6_HUMAN (11-463): 2.62e-75: 245: 48.57
+	Hs
		1344383 TLR9_HUMAN (1-902): 1.39e-102: 344: 21.01		SIGL9_HUMAN (10-463): 1.38e-95: 297: 100.00
+	Hs
		177589 TLR3_HUMAN (1-904): 2.14e-155: 481: 100.00		SIGL5_HUMAN (34-463): 1.35e-25: 111: 17.76
+	Hs
		179956 TLR3_HUMAN (1-904): 2.14e-155: 481: 100.00		SIG11_HUMAN (73-462): 9.19e-25: 109: 21.04
+	Hs
		211423 TLR9_HUMAN (1-902): 1.39e-102: 344: 21.01		SIGL6_HUMAN (11-463): 2.62e-75: 245: 48.57
+	Hs
		179954 TLR3_HUMAN (1-904): 2.14e-155: 481: 100.00		SIG10_HUMAN (42-460): 5.38e-22: 101: 15.56
+	Mm
		885977 TLR8_MOUSE (23-901): 7.9e-99: 334: 21.28		Q6PJ50_MOUSE (10-463): 1.48e-73: 240: 51.74
+	Mm
		885976 TLR8_MOUSE (23-901): 7.9e-99: 334: 21.28		Q3Y597_MOUSE (8-252): 1.17e-70: 228: 52.03
+	Mm
		1265201 TLR4_MOUSE (46-897): 7.68e-95: 319: 19.70		SIG12_MOUSE (10-463): 2.55e-74: 242: 51.74
+	Mm
		1162020 TLR4_MOUSE (46-897): 7.68e-95: 319: 19.70		Q6PJ50_MOUSE (10-463): 1.48e-73: 240: 51.74
+	Mm
		1113884 TLR2_MOUSE (134-899): 4.2e-95: 318: 20.34		Q3Y597_MOUSE (8-252): 1.17e-70: 228: 52.03
+	Mm
		1144428 TLR3_MOUSE (8-904): 2.26e-144: 452: 79.93		CD33_MOUSE (151-413): 1.85e-12: 70.7: 19.08
+	Hs
		177607 TLR9_HUMAN (1-902): 1.39e-102: 344: 21.01		SIGL5_HUMAN (34-463): 1.35e-25: 111: 17.76
+	Mm
		722909 TLR5_MOUSE (5-900): 2.42e-95: 320: 19.81		CD22_MOUSE (8-351): 1.81e-24: 108: 16.29
+	Mm
		722910 TLR2_MOUSE (134-899): 4.2e-95: 318: 20.34		CD22_MOUSE (8-351): 1.81e-24: 108: 16.29
+	Mm
		1265316 TLR5_MOUSE (5-900): 2.42e-95: 320: 19.81		SIGL5_MOUSE (64-463): 1.69e-21: 99.4: 18.04
+	Mm
		1265317 TLR4_MOUSE (46-897): 7.68e-95: 319: 19.70		SIGL5_MOUSE (64-463): 1.69e-21: 99.4: 18.04
+	Mm
		1144431 TLR5_MOUSE (5-900): 2.42e-95: 320: 19.81		CD33_MOUSE (151-413): 1.85e-12: 70.7: 19.08
+	Mm
		1144432 TLR2_MOUSE (134-899): 4.2e-95: 318: 20.34		CD33_MOUSE (151-413): 1.85e-12: 70.7: 19.08