HitPredict

Interactor 1: CFLAR (O15519)
CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
Gene: CFLAR

Interactor 2: M3K14 (Q99558)
Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)
Gene: MAP3K14

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	11002417
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DED~Pkinase
Common GO terms	GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 480 Hs			1 947
+	Hs
		1059350 CASP8_HUMAN (6-478): 8.27e-152: 442: 24.85		M3K14_HUMAN (1-947): 0: 799: 100.00
+	Hs
		1271828 CASPA_HUMAN (4-453): 5.22e-122: 368: 25.41		M3K14_HUMAN (1-947): 0: 799: 100.00
+	Hs
		861756 CASP8_HUMAN (6-478): 8.27e-152: 442: 24.85		PLK1_HUMAN (406-781): 1.04e-106: 345: 26.87
+	Hs
		682146 CASP3_HUMAN (209-479): 8.43e-89: 274: 22.53		AKT2_HUMAN (286-701): 1.96e-133: 411: 20.32
+	Hs
		788236 CASP3_HUMAN (209-479): 8.43e-89: 274: 22.53		AKT3_HUMAN (272-705): 8.39e-132: 406: 19.01
+	Dm
		136291 DRICE_DROME (208-478): 7.42e-82: 258: 19.80		AKT1_DROME (148-719): 1.12e-135: 421: 16.83
+	Hs
		681714 CASP3_HUMAN (209-479): 8.43e-89: 274: 22.53		AKT1_HUMAN (286-713): 3.76e-131: 405: 19.33