Protein: DPOG1
DNA polymerase subunit gamma-1 (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (5'-deoxyribose-phosphate lyase) (EC 4.2.99.-) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha)

Gene: DPOG1, POLG
Organism: Homo sapiens
Interactions: 104
UniProt ID: P54098

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0003887 - DNA-directed DNA polymerase activity
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

867382

DPOG2
DNA polymerase subunit gamma-2

6

0

Small-scale

0.909

High

867335

OXLD1
Oxidoreductase-like domain-containing protein 1

3

0

High-throughput

0.638

High

212045

GATC
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

2

0

High-throughput

0.602

High

258684

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

0

High-throughput

0.602

High

336857

OTC
Ornithine transcarbamylase, mitochondrial

2

0

High-throughput

0.602

High

602081

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

2

0

High-throughput

0.602

High

867339

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

2

0

High-throughput

0.602

High

867345

NIT1
Deaminated glutathione amidase

2

0

High-throughput

0.602

High

867347

TSYL6
Testis-specific Y-encoded-like protein 6

2

0

High-throughput

0.602

High

867360

MGME1
Mitochondrial genome maintenance exonuclease 1

2

0

High-throughput

0.602

High

867371

MTG2
Mitochondrial ribosome-associated GTPase 2

2

0

High-throughput

0.585

High

262766

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

867334

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

867375

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.554

High

867323

TFAM
Transcription factor A, mitochondrial

2

0

High-throughput

0.547

High

867324

SSBP
Single-stranded DNA-binding protein, mitochondrial

2

0

High-throughput

0.547

High

867355

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.536

High

272343

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.513

High

495692

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.513

High

622250

CX7A1
Cytochrome c oxidase subunit 7A1, mitochondrial

1

0

High-throughput

0.513

High

646382

KAD4
Adenylate kinase 4, mitochondrial

1

0

High-throughput

0.513

High

790241

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

0

High-throughput

0.513

High

815354

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

867340

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

0

High-throughput

0.513

High

867346

CBR4
3-oxoacyl-[acyl-carrier-protein] reductase

1

0

High-throughput

0.513

High

867353

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

867362

MYL10
Myosin regulatory light chain 10

1

0

High-throughput

0.513

High

867363

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.513

High

867378

DIC
Mitochondrial dicarboxylate carrier

1

0

High-throughput

0.513

High

867379

NPS3A
Protein NipSnap homolog 3A

1

0

High-throughput

0.513

High

867381

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

867384

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

867385

RT02
Small ribosomal subunit protein uS2m

1

0

High-throughput

0.513

High

867388

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.513

High

867358

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.506

High

126576

P2Y10
Putative P2Y purinoceptor 10

1

1

High-throughput

0.489

High

243345

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.489

High

867342

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

0

Small-scale

0.480

High

264876

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

270006

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

803076

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

867321

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

867326

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

867343

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

2

High-throughput

0.479

High

867348

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

1

High-throughput

0.479

High

867349

FAKD4
FAST kinase domain-containing protein 4

1

2

High-throughput

0.479

High

867350

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

867357

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

867368

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

867370

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

867380

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

327392

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

440432

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

486493

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

499645

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

525465

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

777511

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

789722

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

799189

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

827315

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

867325

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

867327

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.458

High

867328

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

0

High-throughput

0.458

High

867329

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

867330

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

867332

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

867333

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

Small-scale

0.458

High

867336

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

867338

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

867351

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

867352

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

867356

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

867361

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

867364

TR61B
tRNA

1

0

High-throughput

0.458

High

867365

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

867366

RM04
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.458

High

867367

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

867369

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

867372

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

867374

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

867377

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

867386

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

867331

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

2

Small-scale

0.445

High

346318

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.426

High

867337

ATD3B
ATPase family AAA domain-containing protein 3B

1

0

High-throughput

0.426

High

326307

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

2

0

High-throughput

0.328

High

867320

YBEY
Endoribonuclease YbeY

2

0

High-throughput

0.328

High

865023

TTC3
E3 ubiquitin-protein ligase TTC3

1

0

Small-scale

0.288

High

867319

RBM11
Splicing regulator RBM11

1

0

High-throughput

0.282

High

171965

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.279

Low

245222

RAMP2
Receptor activity-modifying protein 2

1

0

High-throughput

0.279

Low

261799

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.279

Low

323658

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

341426

FA12
Coagulation factor XII

1

0

High-throughput

0.279

Low

867354

RT24
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.279

Low

867359

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.279

Low

867373

B2L12
Bcl-2-like protein 12

1

0

High-throughput

0.279

Low

867383

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.279

Low

867387

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

867322

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.249

Low

867341

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

867344

SHLD2
Shieldin complex subunit 2

1

0

High-throughput

0.249

Low

135234

E2F3
Transcription factor E2F3

1

0

Small-scale

0.232

Low

867376

TRM1
tRNA

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024