HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.80	0.738

Property	Details
Experiments	25728680, 24728074
Identification Methods	affinity chromatography technology, pull down, fluorescence polarization spectroscopy
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 1390
+	Hs
		256845 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		MET_HUMAN (1-1390): 0: 1283: 100.00
+	Hs
		441580 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		MET_HUMAN (1-1390): 0: 1283: 100.00
+	Hs
		146584 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		MET_HUMAN (1-1390): 0: 1283: 100.00
+	Hs
		147476 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		MET_HUMAN (1-1390): 0: 1283: 100.00
+	Hs
		181796 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		FGFR3_HUMAN (982-1360): 5.32e-108: 363: 31.83
+	Hs
		147484 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		FGFR3_HUMAN (982-1360): 5.32e-108: 363: 31.83
+	Hs
		181803 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90
+	Hs
		146667 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		INSR_HUMAN (1084-1335): 3.87e-55: 213: 42.11
+	Hs
		181772 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16
+	Hs
		181763 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		INSR_HUMAN (1084-1335): 3.87e-55: 213: 42.11
+	Mm
		193338 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		INSR_MOUSE (1084-1335): 2.21e-52: 204: 40.98
+	Hs
		181866 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75
+	Hs
		181753 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ABL1_HUMAN (1084-1341): 1.06e-51: 201: 41.38
+	Hs
		256853 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75
+	Hs
		435801 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16
+	Hs
		146583 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16
+	Hs
		411523 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		INSR_HUMAN (1084-1335): 3.87e-55: 213: 42.11
+	Hs
		147471 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		INSR_HUMAN (1084-1335): 3.87e-55: 213: 42.11
+	Hs
		1071026 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75
+	Hs
		147522 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75