HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.840

Property	Details
Experiments	25814554, 10022833, unassigned1126
Identification Methods	two hybrid, pull down, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1, SH2~SH3_2, SH2~SOCS_box
Common GO terms	GO:0005159 - insulin-like growth factor receptor binding GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 304
+	Hs
		146607 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		147494 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		181818 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		181787 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		VAV_HUMAN (11-189): 6.6e-47: 170: 28.21
+	Mm
		193378 SOCS3_MOUSE (39-207): 3.5e-41: 141: 27.60		CRKL_MOUSE (2-302): 6.92e-57: 187: 47.10
+	Hs
		411580 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		VAV_HUMAN (11-189): 6.6e-47: 170: 28.21
+	Hs
		181827 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74
+	Hs
		146674 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		181839 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		581062 CISH_HUMAN (22-211): 6.28e-41: 141: 26.45		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		924732 SOCS4_HUMAN (3-210): 8.16e-43: 151: 18.98		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		924938 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Mm
		1141129 VAV2_MOUSE (1-181): 1.07e-38: 143: 17.11		GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67
+	Hs
		855781 VAV2_HUMAN (1-175): 2.65e-39: 144: 17.68		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		146663 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		146669 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		181788 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		411817 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22
+	Mm
		193392 SOCS3_MOUSE (39-207): 3.5e-41: 141: 27.60		NCK1_MOUSE (2-100): 1.35e-10: 63.3: 18.00
+	Hs
		208958 NCK2_HUMAN (2-175): 8.86e-39: 139: 19.77		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00