Protein: EPHB6
Ephrin type-B receptor 6 (HEP) (Tyrosine-protein kinase-defective receptor EPH-6)

Gene: EPHB6
Organism: Homo sapiens
Interactions: 79
UniProt ID: O15197

Gene Ontology (top 5):
GO:0005003 - ephrin receptor activity
GO:0005005 - transmembrane-ephrin receptor activity
GO:0005524 - ATP binding
GO:0005576 - extracellular region
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

181792

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

9

High-throughput

0.811

High

181771

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.789

High

181772

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.789

High

181808

ASB12
Ankyrin repeat and SOCS box protein 12

2

10

High-throughput

0.783

High

181816

TRIB3
Tribbles homolog 3

2

8

High-throughput

0.783

High

181801

NT2NA
Notch homolog 2 N-terminal-like protein A

1

9

High-throughput

0.740

High

181807

STYX
Serine/threonine/tyrosine-interacting protein

1

20

High-throughput

0.698

High

181796

CDC37
Hsp90 co-chaperone Cdc37

1

17

High-throughput

0.691

High

181790

REL
Proto-oncogene c-Rel

3

8

High-throughput

0.675

High

181827

TRI39
E3 ubiquitin-protein ligase TRIM39

3

3

High-throughput

0.675

High

181788

AFAD
Afadin

1

20

Small-scale

0.656

High

181804

DUS18
Dual specificity protein phosphatase 18

1

20

High-throughput

0.625

High

181806

DUS19
Dual specificity protein phosphatase 19

1

20

High-throughput

0.625

High

181769

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

17

Small-scale

0.621

High

181805

CADM4
Cell adhesion molecule 4

1

8

High-throughput

0.618

High

181762

TRI18
E3 ubiquitin-protein ligase Midline-1

1

17

High-throughput

0.618

High

181764

OBSL1
Obscurin-like protein 1

1

6

High-throughput

0.618

High

181775

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.618

High

181779

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

High-throughput

0.618

High

181780

EPHA2
Ephrin type-A receptor 2

1

18

Small-scale

0.618

High

181781

EPHB2
Ephrin type-B receptor 2

1

17

Small-scale

0.618

High

181787

EPHB4
Ephrin type-B receptor 4

1

17

Small-scale

0.618

High

181800

LMTK1
Serine/threonine-protein kinase LMTK1

1

19

High-throughput

0.618

High

181803

UNC5B
Netrin receptor UNC5B

1

15

High-throughput

0.618

High

181811

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

High-throughput

0.618

High

181825

PKHA5
Pleckstrin homology domain-containing family A member 5

1

20

High-throughput

0.618

High

181826

PKHA1
Pleckstrin homology domain-containing family A member 1

1

20

High-throughput

0.618

High

181828

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.618

High

181829

WDR6
tRNA

1

12

High-throughput

0.618

High

181833

RAB21
Ras-related protein Rab-21

1

17

High-throughput

0.618

High

181774

ITF2
Transcription factor 4

3

1

High-throughput

0.616

High

181782

MSX2
Homeobox protein MSX-2

2

3

High-throughput

0.606

High

162389

ANM5
Protein arginine N-methyltransferase 5

2

0

High-throughput

0.580

High

181789

PO6F2
POU domain, class 6, transcription factor 2

2

4

High-throughput

0.553

High

181777

SAT1
Diamine acetyltransferase 1

1

0

High-throughput

0.518

High

181766

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.515

High

181832

IKZF3
Zinc finger protein Aiolos

1

5

High-throughput

0.515

High

181831

PRAF1
Prenylated Rab acceptor protein 1

1

0

High-throughput

0.513

High

129917

PGRC1
Membrane-associated progesterone receptor component 1

1

6

High-throughput

0.500

High

156219

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

2

High-throughput

0.500

High

181763

LANC1
Glutathione S-transferase LANCL1

1

2

High-throughput

0.500

High

181767

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

3

High-throughput

0.500

High

181785

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

2

High-throughput

0.500

High

181797

UBR4
E3 ubiquitin-protein ligase UBR4

1

1

High-throughput

0.500

High

181813

PABP5
Polyadenylate-binding protein 5

1

6

High-throughput

0.500

High

181820

NTPCR
Cancer-related nucleoside-triphosphatase

1

9

High-throughput

0.500

High

171049

VP26C
Vacuolar protein sorting-associated protein 26C

1

2

High-throughput

0.494

High

181784

BCL6
B-cell lymphoma 6 protein

1

4

Small-scale

0.489

High

63282

ODAD3
Outer dynein arm-docking complex subunit 3

1

6

High-throughput

0.479

High

124688

AIP
AH receptor-interacting protein

1

7

High-throughput

0.479

High

181765

SC24A
Protein transport protein Sec24A

1

20

High-throughput

0.479

High

181770

S10A8
Protein S100-A8

1

2

High-throughput

0.479

High

181776

ARF4
ADP-ribosylation factor 4

1

13

High-throughput

0.479

High

181786

COPD
Coatomer subunit delta

1

6

High-throughput

0.479

High

181793

FLOT2
Flotillin-2

1

12

High-throughput

0.479

High

181794

SC23B
Protein transport protein Sec23B

1

20

High-throughput

0.479

High

181795

SMAD2
Mothers against decapentaplegic homolog 2

1

3

High-throughput

0.479

High

181799

RFIP1
Rab11 family-interacting protein 1

1

13

High-throughput

0.479

High

181802

LSR
Lipolysis-stimulated lipoprotein receptor

1

4

High-throughput

0.479

High

181810

US6NL
USP6 N-terminal-like protein

1

12

High-throughput

0.479

High

181818

CDCA3
Cell division cycle-associated protein 3

1

8

High-throughput

0.479

High

181819

PKP2
Plakophilin-2

1

20

High-throughput

0.479

High

181817

HTF4
Transcription factor 12

1

1

High-throughput

0.470

High

181822

GO45
Golgin-45

1

1

High-throughput

0.470

High

137560

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

6

High-throughput

0.457

High

181778

CPT2
Carnitine O-palmitoyltransferase 2, mitochondrial

1

1

High-throughput

0.457

High

181783

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

2

High-throughput

0.457

High

181814

KLD7B
Kelch domain-containing protein 7B

1

1

High-throughput

0.457

High

181768

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

181773

PDIA4
Protein disulfide-isomerase A4

1

20

High-throughput

0.437

High

181809

SEPT8
Septin-8

1

14

High-throughput

0.437

High

181823

GCP60
Golgi resident protein GCP60

1

9

High-throughput

0.437

High

181824

GORS2
Golgi reassembly-stacking protein 2

1

8

High-throughput

0.437

High

181830

DJB11
DnaJ homolog subfamily B member 11

1

16

High-throughput

0.437

High

181791

INCA1
Protein INCA1

4

0

High-throughput

0.364

High

181798

MARC1
Mitochondrial amidoxime-reducing component 1

2

0

High-throughput

0.316

High

181812

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.316

High

181815

TEKT5
Tektin-5

2

0

High-throughput

0.316

High

181821

NIF3L
NIF3-like protein 1

1

0

High-throughput

0.299

High


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Last updated: 11Aug2025