HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: IL2RB (P14784)
Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)
Gene: IL2RB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.631

Property	Details
Experiments	29991678, 29674694, 11133764
Identification Methods	affinity chromatography technology, unspecified method
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0019221 - cytokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 551
+	Hs
		411578 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		IL2RB_HUMAN (1-551): 0: 527: 100.00
+	Hs
		181779 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		GHR_HUMAN (7-485): 4.72e-75: 252: 16.57
+	Hs
		146586 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		GHR_HUMAN (7-485): 4.72e-75: 252: 16.57
+	Hs
		146590 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		PRLR_HUMAN (24-547): 4.84e-75: 251: 12.96
+	Hs
		560471 VAV2_HUMAN (1-175): 2.65e-39: 144: 17.68		PRLR_HUMAN (24-547): 4.84e-75: 251: 12.96
+	Hs
		500974 CISH_HUMAN (22-211): 6.28e-41: 141: 26.45		GHR_HUMAN (7-485): 4.72e-75: 252: 16.57
+	Rn
		70070 B1WBX9_RAT (22-211): 3.28e-41: 142: 26.56		GHR_RAT (27-485): 3.9e-60: 212: 15.27
+	Hs
		146592 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49
+	Hs
		181790 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		IL7RA_HUMAN (92-351): 4.68e-52: 185: 16.60
+	Mm
		540271 CISH_MOUSE (22-211): 1.94e-41: 142: 26.56		EPOR_MOUSE (7-427): 1.75e-58: 204: 19.30
+	Hs
		146591 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		IL7RA_HUMAN (92-351): 4.68e-52: 185: 16.60
+	Hs
		256850 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		IL4RA_HUMAN (1-483): 2.01e-42: 164: 17.49
+	Mm
		411919 LCK_MOUSE (4-194): 7.31e-39: 141: 12.98		CSF3R_MOUSE (7-361): 5.25e-39: 154: 14.80
+	Hs
		181806 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		IL3RB_HUMAN (13-240): 2.54e-16: 84.6: 17.01
+	Hs
		181812 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		TPOR_HUMAN (1-235): 3.46e-14: 77.3: 13.68
+	Mm
		193361 SOCS2_MOUSE (37-211): 1.07e-42: 144: 28.57		LEPR_MOUSE (33-243): 2.07e-20: 97.6: 17.65
+	Mm
		817306 CISH_MOUSE (22-211): 1.94e-41: 142: 26.56		LEPR_MOUSE (33-243): 2.07e-20: 97.6: 17.65
+	Mm
		817309 SOCS6_MOUSE (66-209): 7.1e-39: 141: 26.06		LEPR_MOUSE (33-243): 2.07e-20: 97.6: 17.65
+	Mm
		645935 CISH_MOUSE (22-211): 1.94e-41: 142: 26.56		IL3B2_MOUSE (3-240): 6.68e-19: 92.7: 14.40
+	Mm
		645937 CISH_MOUSE (22-211): 1.94e-41: 142: 26.56		IL3RB_MOUSE (3-240): 3.28e-18: 90.4: 15.94