Protein: EPHA5
Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7)

Gene: EPHA5
Organism: Homo sapiens
Interactions: 148
UniProt ID: P54756

Gene Ontology (top 5):
GO:0005003 - ephrin receptor activity
GO:0005004 - GPI-linked ephrin receptor activity
GO:0005005 - transmembrane-ephrin receptor activity
GO:0005524 - ATP binding
GO:0005791 - rough endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

914387

EFNB2
Ephrin-B2

4

20

High-throughput

0.892

High

914525

EFNA5
Ephrin-A5

2

20

High-throughput

0.811

High

774233

BASI
Basigin

2

20

High-throughput

0.767

High

410733

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

Small-scale

0.757

High

710141

EPHA2
Ephrin type-A receptor 2

1

19

High-throughput

0.715

High

710612

EPHA3
Ephrin type-A receptor 3

1

19

High-throughput

0.691

High

931826

EPHB4
Ephrin type-B receptor 4

1

16

High-throughput

0.691

High

931843

PAK2
Serine/threonine-protein kinase PAK 2

1

17

High-throughput

0.691

High

931847

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

18

High-throughput

0.691

High

252670

TSN3
Tetraspanin-3

3

6

High-throughput

0.667

High

931866

AN13A
Ankyrin repeat domain-containing protein 13A

1

4

High-throughput

0.646

High

931856

CDC37
Hsp90 co-chaperone Cdc37

1

20

High-throughput

0.618

High

126522

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

348080

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

20

High-throughput

0.618

High

363031

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

376486

LDLR
Low-density lipoprotein receptor

1

6

High-throughput

0.618

High

466171

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

580953

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

593949

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.618

High

699662

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

High-throughput

0.618

High

711286

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.618

High

767409

RADI
Radixin

1

20

High-throughput

0.618

High

787128

BMR1A
Bone morphogenetic protein receptor type-1A

1

20

High-throughput

0.618

High

827721

STAT3
Signal transducer and activator of transcription 3

1

11

Small-scale

0.618

High

835620

KPCI
Protein kinase C iota type

1

20

High-throughput

0.618

High

931827

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

931828

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

931829

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

931831

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.618

High

931832

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

931833

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

931835

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

19

High-throughput

0.618

High

931837

NOTC2
Neurogenic locus notch homolog protein 2

1

18

High-throughput

0.618

High

931838

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

High-throughput

0.618

High

931840

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

20

High-throughput

0.618

High

931842

DLG1
Disks large homolog 1

1

20

High-throughput

0.618

High

931868

UNC5B
Netrin receptor UNC5B

1

19

High-throughput

0.618

High

931869

MINK1
Misshapen-like kinase 1

1

20

High-throughput

0.618

High

931870

EHBP1
EH domain-binding protein 1

1

20

High-throughput

0.618

High

931873

PARD3
Partitioning defective 3 homolog

1

20

High-throughput

0.618

High

931882

ERBIN
Erbin

1

20

High-throughput

0.618

High

931901

PKHA1
Pleckstrin homology domain-containing family A member 1

1

20

High-throughput

0.618

High

931902

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.618

High

931903

WDR6
tRNA

1

17

High-throughput

0.618

High

931905

LIN7C
Protein lin-7 homolog C

1

20

High-throughput

0.618

High

931911

TNIK
TRAF2 and NCK-interacting protein kinase

1

20

High-throughput

0.618

High

931912

DP13A
DCC-interacting protein 13-alpha

1

10

High-throughput

0.618

High

931915

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

14

High-throughput

0.618

High

931919

M4K5
Mitogen-activated protein kinase kinase kinase kinase 5

1

20

High-throughput

0.618

High

440461

FYN
Tyrosine-protein kinase Fyn

1

20

High-throughput

0.590

High

931863

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

7

High-throughput

0.575

High

931841

TRAF2
TNF receptor-associated factor 2

2

9

Small-scale

0.558

High

931897

DUS21
Dual specificity protein phosphatase 21

1

20

High-throughput

0.555

High

136345

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.553

High

296471

STAM2
Signal transducing adapter molecule 2

1

20

High-throughput

0.553

High

611050

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

20

High-throughput

0.553

High

931845

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.553

High

931857

PDZ11
PDZ domain-containing protein 11

1

20

High-throughput

0.553

High

931877

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

20

High-throughput

0.553

High

931879

STAM1
Signal transducing adapter molecule 1

1

20

High-throughput

0.553

High

931898

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

18

High-throughput

0.553

High

931900

PKHA5
Pleckstrin homology domain-containing family A member 5

1

20

High-throughput

0.553

High

931913

KDIS
Kinase D-interacting substrate of 220 kDa

1

14

High-throughput

0.553

High

931867

NRSN1
Neurensin-1

1

1

High-throughput

0.536

High

931872

S22A8
Organic anion transporter 3

1

5

High-throughput

0.536

High

931885

SCN2A
Sodium channel protein type 2 subunit alpha

1

10

High-throughput

0.536

High

626133

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

19

High-throughput

0.514

High

861532

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

10

High-throughput

0.501

High

931844

ATM
Serine-protein kinase ATM

1

14

Small-scale

0.501

High

869827

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

2

High-throughput

0.500

High

931889

NTPCR
Cancer-related nucleoside-triphosphatase

1

9

High-throughput

0.500

High

931896

CST9L
Cystatin-9-like

1

5

High-throughput

0.489

High

931910

FBX2
F-box only protein 2

1

8

High-throughput

0.489

High

222853

PRC1
Protein regulator of cytokinesis 1

1

8

High-throughput

0.479

High

269752

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

1

20

High-throughput

0.479

High

299953

CBPD
Carboxypeptidase D

1

8

High-throughput

0.479

High

332936

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

10

High-throughput

0.479

High

343336

SNP29
Synaptosomal-associated protein 29

1

6

High-throughput

0.479

High

577675

PLAK
Junction plakoglobin

1

20

High-throughput

0.479

High

764574

CTNB1
Catenin beta-1

1

20

High-throughput

0.479

High

889232

NUMB
Protein numb homolog

1

20

High-throughput

0.479

High

898061

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

10

High-throughput

0.479

High

912763

AGFG1
Arf-GAP domain and FG repeat-containing protein 1

1

13

High-throughput

0.479

High

931830

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

10

High-throughput

0.479

High

931834

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

12

High-throughput

0.479

High

931836

DSC2
Desmocollin-2

1

20

High-throughput

0.479

High

931839

FCHO2
F-BAR domain only protein 2

1

15

High-throughput

0.479

High

931846

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

4

High-throughput

0.479

High

931849

DSG2
Desmoglein-2

1

20

High-throughput

0.479

High

931851

FLOT2
Flotillin-2

1

12

High-throughput

0.479

High

931852

EPN4
Clathrin interactor 1

1

4

High-throughput

0.479

High

931853

SC23A
Protein transport protein Sec23A

1

20

High-throughput

0.479

High

931854

SC23B
Protein transport protein Sec23B

1

20

High-throughput

0.479

High

931855

AAAT
Neutral amino acid transporter B(0)

1

16

High-throughput

0.479

High

931858

F1711
Protein FAM171A1

1

15

High-throughput

0.479

High

931871

VANG1
Vang-like protein 1

1

6

High-throughput

0.479

High

931878

US6NL
USP6 N-terminal-like protein

1

14

High-throughput

0.479

High

931884

NIBA2
Protein Niban 2

1

7

High-throughput

0.479

High

931886

PKP4
Plakophilin-4

1

20

High-throughput

0.479

High

931888

PKP2
Plakophilin-2

1

20

High-throughput

0.479

High

931890

ESYT1
Extended synaptotagmin-1

1

12

High-throughput

0.479

High

931893

S38A1
Sodium-coupled neutral amino acid symporter 1

1

3

High-throughput

0.479

High

931894

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

9

High-throughput

0.479

High

931914

MYO6
Unconventional myosin-VI

1

6

High-throughput

0.479

High

931918

NISCH
Nischarin

1

20

High-throughput

0.479

High

469274

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

0

High-throughput

0.458

High

931917

TPPC4
Trafficking protein particle complex subunit 4

1

0

High-throughput

0.458

High

228810

SCO2
Protein SCO2 homolog, mitochondrial

1

2

High-throughput

0.457

High

285621

BAF
Barrier-to-autointegration factor

1

6

High-throughput

0.457

High

829324

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

9

High-throughput

0.457

High

931876

S39A7
Zinc transporter SLC39A7

1

11

High-throughput

0.457

High

931891

PDIP3
Polymerase delta-interacting protein 3

1

4

High-throughput

0.457

High

254905

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

12

High-throughput

0.445

High

931848

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

10

High-throughput

0.445

High

931881

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

20

High-throughput

0.445

High

50803

CA226
Uncharacterized protein C1orf226

1

2

High-throughput

0.437

High

71304

F1712
Protein FAM171A2

1

15

High-throughput

0.437

High

71717

NUD19
Acyl-coenzyme A diphosphatase NUDT19

1

3

High-throughput

0.437

High

169489

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

20

High-throughput

0.437

High

255403

SNX2
Sorting nexin-2

1

19

High-throughput

0.437

High

291273

NU155
Nuclear pore complex protein Nup155

1

5

High-throughput

0.437

High

338303

SC24A
Protein transport protein Sec24A

1

20

High-throughput

0.437

High

338445

SC24B
Protein transport protein Sec24B

1

20

High-throughput

0.437

High

873190

COPD
Coatomer subunit delta

1

7

High-throughput

0.437

High

888690

ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial

1

5

High-throughput

0.437

High

906019

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

5

High-throughput

0.437

High

931850

SEPT6
Septin-6

1

16

High-throughput

0.437

High

931861

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

3

High-throughput

0.437

High

931862

ZFY16
Zinc finger FYVE domain-containing protein 16

1

20

High-throughput

0.437

High

931865

M21D2
Nucleotidyltransferase MB21D2

1

3

High-throughput

0.437

High

931874

SMAP2
Stromal membrane-associated protein 2

1

11

High-throughput

0.437

High

931875

BRK1
Protein BRICK1

1

3

High-throughput

0.437

High

931880

CK5P3
CDK5 regulatory subunit-associated protein 3

1

3

High-throughput

0.437

High

931883

CLCC1
Chloride channel CLIC-like protein 1

1

4

High-throughput

0.437

High

931887

CDCA3
Cell division cycle-associated protein 3

1

9

High-throughput

0.437

High

931892

RHG39
Rho GTPase-activating protein 39

1

13

High-throughput

0.437

High

931895

GCP60
Golgi resident protein GCP60

1

9

High-throughput

0.437

High

931899

GORS2
Golgi reassembly-stacking protein 2

1

11

High-throughput

0.437

High

931904

TB22B
TBC1 domain family member 22B

1

12

High-throughput

0.437

High

931906

GGA3
ADP-ribosylation factor-binding protein GGA3

1

20

High-throughput

0.437

High

931907

SEP10
Septin-10

1

14

High-throughput

0.437

High

931908

F135A
Protein FAM135A

1

6

High-throughput

0.437

High

931909

TRM7
tRNA

1

7

High-throughput

0.437

High

931916

SNX6
Sorting nexin-6

1

18

High-throughput

0.437

High

931860

CV042
Uncharacterized protein C22orf42

1

0

High-throughput

0.279

Low

702556

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

High-throughput

0.249

Low

931859

F91A1
Protein FAM91A1

1

0

High-throughput

0.249

Low

931864

TPPC5
Trafficking protein particle complex subunit 5

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025