HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	14968112
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 1620
+	Hs
		256861 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		ALK_HUMAN (1-1620): 0: 1883: 100.00
+	Hs
		1356638 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		ALK_HUMAN (1-1620): 0: 1883: 100.00
+	Hs
		181866 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ERBB4_HUMAN (882-1547): 2.9e-122: 418: 22.24
+	Hs
		256853 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		ERBB4_HUMAN (882-1547): 2.9e-122: 418: 22.24
+	Hs
		181796 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		FGFR3_HUMAN (952-1449): 6.42e-121: 401: 26.31
+	Hs
		1071026 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		ERBB4_HUMAN (882-1547): 2.9e-122: 418: 22.24
+	Hs
		147522 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		ERBB4_HUMAN (882-1547): 2.9e-122: 418: 22.24
+	Hs
		146667 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Mm
		193338 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		INSR_MOUSE (973-1484): 6.89e-113: 392: 32.38
+	Hs
		181846 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		TIE2_HUMAN (954-1389): 7.66e-115: 393: 29.30
+	Hs
		181763 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Hs
		181772 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		147484 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		FGFR3_HUMAN (952-1449): 6.42e-121: 401: 26.31
+	Mm
		193358 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		FAK2_MOUSE (1061-1496): 2.01e-110: 378: 28.31
+	Hs
		445884 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		ROS1_HUMAN (1039-1461): 3.68e-112: 397: 37.75
+	Hs
		411523 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Hs
		147471 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Hs
		435801 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Dm
		526800 Q8INY1_DROME (26-210): 6.61e-43: 154: 23.00		7LESS_DROME (1022-1417): 2.18e-67: 254: 36.34
+	Hs
		146579 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07