HitPredict

Interactor 1: TPSN (O15533)
Tapasin (TPN) (TPSN) (NGS-17) (TAP-associated protein) (TAP-binding protein)
Gene: TAPBP

Interactor 2: DPB1 (P04440)
HLA class II histocompatibility antigen, DP beta 1 chain (HLA class II histocompatibility antigen, DP(W4) beta chain) (MHC class II antigen DPB1)
Gene: HLA-DPB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1-set~C1-set, C1-set~MHC_II_beta
Common GO terms	GO:0000139 - Golgi membrane GO:0042605 - peptide antigen binding GO:0098553 - lumenal side of endoplasmic reticulum membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 448 Hs			1 258
+	Hs
		182244 TPSN_HUMAN (1-448): 2.71e-172: 492: 100.00		DQB1_HUMAN (3-253): 3.37e-92: 274: 62.45
+	Hs
		182246 TPSN_HUMAN (1-448): 2.71e-172: 492: 100.00		HLAA_HUMAN (34-258): 1.25e-88: 268: 23.71
+	Hs
		182242 TPSN_HUMAN (1-448): 2.71e-172: 492: 100.00		HLAB_HUMAN (34-231): 4.74e-77: 239: 22.66
+	Mm
		354643 TPSN_MOUSE (13-447): 5.26e-160: 461: 74.25		HA11_MOUSE (34-257): 6.46e-81: 248: 22.51
+	Hs
		382512 TPSNR_HUMAN (2-426): 8.01e-120: 359: 25.38		HLAA_HUMAN (34-258): 1.25e-88: 268: 23.71
+	Hs
		69945 TPSNR_HUMAN (2-426): 8.01e-120: 359: 25.38		B1PKZ2_HUMAN (34-258): 7.77e-85: 259: 23.71
+	Hs
		354547 TPSNR_HUMAN (2-426): 8.01e-120: 359: 25.38		HLAB_HUMAN (34-231): 4.74e-77: 239: 22.66
+	Hs
		182258 TPSN_HUMAN (1-448): 2.71e-172: 492: 100.00		DMB_HUMAN (73-250): 4.54e-18: 82.8: 28.89
+	Hs
		182272 TPSN_HUMAN (1-448): 2.71e-172: 492: 100.00		HFE_HUMAN (56-246): 1.34e-13: 71.2: 27.86
+	Hs
		182243 TPSN_HUMAN (1-448): 2.71e-172: 492: 100.00		DQA1_HUMAN (124-253): 7.19e-13: 68.2: 29.85
+	Hs
		182265 TPSN_HUMAN (1-448): 2.71e-172: 492: 100.00		B2MG_HUMAN (114-215): 3.41e-12: 63.5: 33.33
+	Mm
		537333 TPSN_MOUSE (13-447): 5.26e-160: 461: 74.25		HA2B_MOUSE (124-246): 1.88e-14: 72.8: 32.28
+	Hs
		355002 BTNL2_HUMAN (161-401): 1.13e-13: 74.6: 16.94		DRB1_HUMAN (1-256): 1.41e-93: 277: 62.40
+	Hs
		355067 BTNL2_HUMAN (161-401): 1.13e-13: 74.6: 16.94		DQB1_HUMAN (3-253): 3.37e-92: 274: 62.45
+	Hs
		382554 BTNL2_HUMAN (161-401): 1.13e-13: 74.6: 16.94		HLAA_HUMAN (34-258): 1.25e-88: 268: 23.71
+	Hs
		945222 BTNL2_HUMAN (161-401): 1.13e-13: 74.6: 16.94		DRB3_HUMAN (1-256): 2.8e-89: 266: 59.69
+	Hs
		588780 NR3L1_HUMAN (172-443): 4.33e-54: 188: 18.98		DPA1_HUMAN (124-246): 3e-17: 80.5: 34.13
+	Hs
		1103672 NECT3_HUMAN (166-415): 2.99e-20: 95.1: 15.54		HFE_HUMAN (56-246): 1.34e-13: 71.2: 27.86
+	Hs
		1278670 BTNL2_HUMAN (161-401): 1.13e-13: 74.6: 16.94		HMR1_HUMAN (50-257): 1.6e-17: 82.4: 28.24
+	Hs
		354786 BTNL2_HUMAN (161-401): 1.13e-13: 74.6: 16.94		DRA_HUMAN (58-238): 3.71e-14: 72: 30.44