HitPredict

Interactor 1: PRS4 (O16368)
Probable 26S proteasome regulatory subunit 4
Gene: rpt-2

Interactor 2: Q9GZH5 (Q9GZH5)
26S proteasome non-ATPase regulatory subunit 2
Gene: rpn-1

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.820

Property	Details
Experiments	12679813, 14704431, 11559592
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	AAA_lid_3~RPN1_C, AAA_lid_3~RPN1_RPN2_N
Common GO terms	GO:0005634 - nucleus GO:0008540 - proteasome regulatory particle, base subcomplex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 443 Ce			1 981
+	Hs
		66339 A8K2M0_HUMAN (53-438): 3.45e-141: 412: 46.89		PSMD2_HUMAN (2-972): 0: 1099: 44.01
+	Hs
		1027680 Q53HB3_HUMAN (28-443): 7.49e-134: 394: 85.34		PSMD2_HUMAN (2-972): 0: 1099: 44.01
+	Hs
		1027683 Q53XL8_HUMAN (28-443): 6.72e-134: 394: 85.34		PSMD2_HUMAN (2-972): 0: 1099: 44.01
+	Hs
		906819 PRS4_HUMAN (28-443): 6.72e-134: 394: 85.34		PSMD2_HUMAN (2-972): 0: 1099: 44.01
+	At
		1352075 PRS6B_ARATH (54-442): 6.04e-142: 413: 46.02		PSD2A_ARATH (33-973): 0: 1000: 39.10
+	At
		1352342 PRS4B_ARATH (1-443): 1.66e-136: 401: 75.17		PSD2A_ARATH (33-973): 0: 1000: 39.10
+	At
		1167708 PRS4A_ARATH (1-443): 2.11e-136: 400: 74.72		PSD2B_ARATH (33-973): 0: 1000: 38.47
+	At
		1352344 PRS4A_ARATH (1-443): 2.11e-136: 400: 74.72		PSD2A_ARATH (33-973): 0: 1000: 39.10
+	Sc
		753896 PRS10_YEAST (3-443): 2.56e-143: 417: 36.12		RPN1_YEAST (11-973): 0: 983: 37.53
+	At
		1341456 PS10B_ARATH (69-439): 2.81e-126: 373: 40.70		PSD2A_ARATH (33-973): 0: 1000: 39.10
+	Sc
		753835 PRS4_YEAST (1-443): 1.19e-128: 380: 68.17		RPN1_YEAST (11-973): 0: 983: 37.53
+	Dm
		820527 PRS4_DROME (1-443): 9.8e-135: 396: 84.42		Q9VW54_DROME (51-972): 0: 945: 45.26
+	Dm
		186162 PRS8_DROME (49-443): 3.22e-127: 376: 44.36		Q9VW54_DROME (51-972): 0: 945: 45.26
+	At
		221383 PRS4A_ARATH (1-443): 2.11e-136: 400: 74.72		PSD1A_ARATH (47-787): 0: 609: 18.56
+	At
		1341469 PRS4A_ARATH (1-443): 2.11e-136: 400: 74.72		PSD1B_ARATH (47-787): 0: 604: 18.32
+	Hs
		906907 PRS4_HUMAN (28-443): 6.72e-134: 394: 85.34		PSMD1_HUMAN (47-787): 0: 571: 17.12
+	Sc
		693337 PRS10_YEAST (3-443): 2.56e-143: 417: 36.12		RPN2_YEAST (47-765): 1.07e-160: 499: 17.45
+	Sc
		693312 PRS4_YEAST (1-443): 1.19e-128: 380: 68.17		RPN2_YEAST (47-765): 1.07e-160: 499: 17.45
+	Dm
		820502 PRS4_DROME (1-443): 9.8e-135: 396: 84.42		PSMD1_DROME (47-787): 8.61e-145: 459: 15.96
+	Dm
		186132 PRS8_DROME (49-443): 3.22e-127: 376: 44.36		PSMD1_DROME (47-787): 8.61e-145: 459: 15.96